Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Pradip De"'
Autor:
Jacob J. Adashek, Chinmayi Pandya, Nicholas J. Maragakis, Pradip De, Philip R. Cohen, Shumei Kato, Razelle Kurzrock
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Neuregulin-1 (NRG1) is implicated in both cancer and neurologic diseases such as amyotrophic lateral sclerosis (ALS); however, to date, there has been little cross-field discussion between neurology and oncology in regard to these
Externí odkaz:
https://doaj.org/article/5510840f22664d2da2e8c1900f898037
Autor:
Jacob J. Adashek, Shumei Kato, Daisuke Nishizaki, Hirotaka Miyashita, Pradip De, Suzanna Lee, Sarabjot Pabla, Mary Nesline, Jeffrey M. Conroy, Paul DePietro, Scott Lippman, Razelle Kurzrock
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 13155-13166 (2023)
Abstract Background Lymphocyte activation gene 3 (LAG‐3) or CD223 is a transmembrane protein that serves as an immune checkpoint which attenuates T‐cell activation. Many clinical trials of LAG‐3 inhibitors have had modest effects, but recent da
Externí odkaz:
https://doaj.org/article/cfe72fc33e194e9395740e5950d4b95c
Autor:
Raed Sulaiman, Adam Dale, Xiaoqian Lin, Jennifer C. Aske, Kris Gaster, David Starks, Luis Rojas Espaillat, Pradip De, Nandini Dey
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3441 (2024)
Lymphovascular invasion (LVSI) is defined as the presence of tumor cells within a definite endothelial-lined space (lymphatics or blood vessels) in the organ surrounding invasive carcinoma. The presence of LVI is associated with an increased risk of
Externí odkaz:
https://doaj.org/article/2d5f3e409be34675868e4e8e293e9bcd
Autor:
Hanna E. Persha, Shumei Kato, Pradip De, Jacob J. Adashek, Jason K. Sicklick, Vivek Subbiah, Razelle Kurzrock
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-5 (2022)
Abstract There is a paucity of information about molecularly driven therapy in osteosarcomas. We report a 31-year-old woman with chemotherapy–refractory metastatic osteosarcoma who was successfully treated with the combination of palbociclib (CDK4/
Externí odkaz:
https://doaj.org/article/9569186ceeb542d5af064c6816ae1426
Autor:
Jason K. Sicklick, Shumei Kato, Ryosuke Okamura, Hitendra Patel, Mina Nikanjam, Paul T. Fanta, Michael E. Hahn, Pradip De, Casey Williams, Jessica Guido, Benjamin M. Solomon, Rana R. McKay, Amy Krie, Sarah G. Boles, Jeffrey S. Ross, J. Jack Lee, Brian Leyland-Jones, Scott M. Lippman, Razelle Kurzrock
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background Malignancies are molecularly complex and become more resistant with each line of therapy. We hypothesized that offering matched, individualized combination therapies to patients with treatment-naïve, advanced cancers would be fea
Externí odkaz:
https://doaj.org/article/ce82766f53714708a38b7c9764d67487
Autor:
Raed Sulaiman, Pradip De, Jennifer C. Aske, Xiaoqian Lin, Adam Dale, Nischal Koirala, Kris Gaster, Luis Rojas Espaillat, David Starks, Nandini Dey
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11079 (2023)
The bipartite landscape of tumor cells and stromal cells determines a tumor’s response to treatment during disease management. In endometrial cancers (ECs), the mechanistic contribution of PD-L1/L2 and PD-1 signaling of the host’s tumor microenvi
Externí odkaz:
https://doaj.org/article/4440ab4ebe2b4206b8d0cf736daea14c
Autor:
Raed Sulaiman, Pradip De, Jennifer C. Aske, Xiaoqian Lin, Adam Dale, Kris Gaster, Luis Rojas Espaillat, David Starks, Nandini Dey
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1326 (2023)
The management of advanced or recurrent endometrial cancers presents a challenge due to the development of resistance to treatments. The knowledge regarding the role of the tumor microenvironment (TME) in determining the disease’s progression and t
Externí odkaz:
https://doaj.org/article/ba8f21249e95479085a329abb8dfeff8
Autor:
Raed Sulaiman, Pradip De, Jennifer C. Aske, Xiaoqian Lin, Adam Dale, Kris Gaster, Luis Rojas Espaillat, David Starks, Nandini Dey
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6449 (2023)
Cancer-associated fibroblasts (CAFs) within a solid tumor can support the progression of cancer. We studied the identification and characterization of patient-derived endometrial CAFs in the context of their clinical relevance in endometrial cancers.
Externí odkaz:
https://doaj.org/article/fb4b05b1198d4969a879bac9335737bc
Autor:
Raed Sulaiman, Pradip De, Jennifer C. Aske, Xiaoqian Lin, Adam Dale, Nischal Koirala, Kris Gaster, Luis Rojas Espaillat, David Starks, Nandini Dey
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 112 (2023)
Ovarian cancers rank first in both aggressiveness and dismal prognosis among gynecological neoplasms. The poor outcome is explained by the fact that most patients present with late-stage disease and progress through the first line of treatment. Ovari
Externí odkaz:
https://doaj.org/article/fd218910569e4b56a9bce3300ef45fca
Autor:
Raed Sulaiman, Pradip De, Jennifer C. Aske, Xiaoqian Lin, Adam Dale, Ethan Vaselaar, Cheryl Ageton, Kris Gaster, Luis Rojas Espaillat, David Starks, Nandini Dey
Publikováno v:
Cancers, Vol 14, Iss 19, p 4577 (2022)
The blood of patients with solid tumors contains circulating tumor-associated cells, including epithelial cells originating from the tumor mass, such as circulating tumor cells (CTCs), or phagocytic myeloid cells (differentiated monocytes), such as c
Externí odkaz:
https://doaj.org/article/0372a5a96e27434e9ea3e2f737d20644