Výsledky vyhledávání - "Pradeep Ramalingam"

Akademický článek

Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response

Autor: Pradeep Ramalingam, Michael C. Gutkin, Michael G. Poulos, Taylor Tillery, Chelsea Doughty, Agatha Winiarski, Ana G. Freire, Shahin Rafii, David Redmond, Jason M. Butler

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract Aging associated defects within stem cell-supportive niches contribute towards age-related decline in stem cell activity. However, mechanisms underlying age-related niche defects, and whether restoring niche function can improve stem cell fi

Externí odkaz: https://doaj.org/article/bfeb0e9c16e84018b805b3d540fe3b9c

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Akademický článek

Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF

Autor: Pradeep Ramalingam, Michael G. Poulos, Elisa Lazzari, Michael C. Gutkin, David Lopez, Christopher C. Kloss, Michael J. Crowley, Lizabeth Katsnelson, Ana G. Freire, Matthew B. Greenblatt, Christopher Y. Park, Jason M. Butler

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)

Myelosuppressive injuries lead to chronic MAPK activation and impair blood reconstitution. Here, the authors show that chronic activation endothelial MAPK impairs hematopoietic stem cell (HSC) function through NFkB signaling, and that post-myelosuppr

Externí odkaz: https://doaj.org/article/6b54770221c34086b376c539aef6277a

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Akademický článek

Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis

Autor: Michael G. Poulos, Pradeep Ramalingam, Michael C. Gutkin, Maria Kleppe, Michael Ginsberg, Michael J. P. Crowley, Olivier Elemento, Ross L. Levine, Shahin Rafii, Jan Kitajewski, Matthew B. Greenblatt, Jae-Hyuck Shim, Jason M. Butler

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)

The complex microenvironmental signalling pathways that govern haematopoietic stem cell (HSC) activity remain poorly defined. Here, the authors identify endothelial NF-κB signalling as regulating regenerative HSC function, accelerating haematopoieti

Externí odkaz: https://doaj.org/article/95743d5eec914dfda2ea75f85a602491

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Akademický článek

Vascular Platform to Define Hematopoietic Stem Cell Factors and Enhance Regenerative Hematopoiesis

Autor: Michael G. Poulos, Michael J.P. Crowley, Michael C. Gutkin, Pradeep Ramalingam, William Schachterle, Jean-Leon Thomas, Olivier Elemento, Jason M. Butler

Publikováno v: Stem Cell Reports, Vol 5, Iss 5, Pp 881-894 (2015)

Hematopoietic stem cells (HSCs) inhabit distinct microenvironments within the adult bone marrow (BM), which govern the delicate balance between HSC quiescence, self-renewal, and differentiation. Previous reports have proposed that HSCs localize to th

Externí odkaz: https://doaj.org/article/06c03862ec6a47019427c26a553e3d6c

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Akademický článek

Fluorescence acquisition during hybridization phase in quantitative real-time PCR improves specificity and signal-to-noise ratio

Autor: Mohit Mehndiratta, Jayanth Kumar Palanichamy, Pradeep Ramalingam, Arnab Pal, Prerna Das, Subrata Sinha, Parthaprasad Chattopadhyay

Publikováno v: BioTechniques, Vol 45, Iss 6, Pp 625-634 (2008)

Quantitative real-time PCR (qPCR) is a standard method used for quantification of specific gene expression. This utilizes either dsDNA binding dyes or probe based chemistry. While dsDNA binding dyes have the advantage of low cost and flexibility, flu

Externí odkaz: https://doaj.org/article/cedad76fe1054a04b22c7d55b1273a2b

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Akademický článek

Gene Silencing and Activation of Human Papillomavirus 18 Is Modulated by Sense Promoter Associated RNA in Bidirectionally Transcribed Long Control Region.

Autor: Muzaffer Ahmad Kassab, Madeeha Mudassir, Anand Singh, Muthuraman N, Mohita Bhagat, Jayanth Kumar Palanichamy, Pradeep Ramalingam, Kunzang Chosdol, Subrata Sinha, Parthaprasad Chattopadhyay

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128416 (2015)

Recently various studies have demonstrated the role of promoter associated non-coding RNAs (pRNA) in dsRNA induced transcriptional gene silencing and activation. However the exact mechanistic details of these processes with respect to the orientation

Externí odkaz: https://doaj.org/article/a1204911a5794827890c80533535b433

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