Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Pradeep Rajasekhar"'
Autor:
Shene Chiou, Aysha H Al-Ani, Yi Pan, Komal M Patel, Isabella Y Kong, Lachlan W Whitehead, Amanda Light, Samuel N Young, Marilou Barrios, Callum Sargeant, Pradeep Rajasekhar, Leah Zhu, Anne Hempel, Ann Lin, James A Rickard, Cathrine Hall, Pradnya Gangatirkar, Raymond KH Yip, Wayne Cawthorne, Annette V Jacobsen, Christopher R Horne, Katherine R Martin, Lisa J Ioannidis, Diana S Hansen, Jessica Day, Ian P Wicks, Charity Law, Matthew E Ritchie, Rory Bowden, Joanne M Hildebrand, Lorraine A O’Reilly, John Silke, Lisa Giulino-Roth, Ellen Tsui, Kelly L Rogers, Edwin D Hawkins, Britt Christensen, James M Murphy, André L Samson
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1717-1749 (2024)
Abstract Necroptosis is a lytic form of regulated cell death reported to contribute to inflammatory diseases of the gut, skin and lung, as well as ischemic-reperfusion injuries of the kidney, heart and brain. However, precise identification of the ce
Externí odkaz:
https://doaj.org/article/3261c59629e24716b5f237cbc3d2531c
Autor:
Kathryn Prame Kumar, Jenny L. Wilson, Huynh Nguyen, Liam D. McKay, Shu Wen Wen, Tara Sepehrizadeh, Michael de Veer, Pradeep Rajasekhar, Simona E. Carbone, Michael J. Hickey, Daniel P. Poole, Connie H. Y. Wong
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 3 (2024)
Background Gut dysmotility is common after ischemic stroke, but the mechanism underlying this response is unknown. Under homeostasis, gut motility is regulated by the neurons of the enteric nervous system that control contractile/relaxation activity
Externí odkaz:
https://doaj.org/article/303acb2ee544421b893a1f5027677127
Autor:
Jesse J. DiCello, Simona E. Carbone, Ayame Saito, Pradeep Rajasekhar, Rhian A. Ceredig, Vi Pham, Celine Valant, Arthur Christopoulos, Nicholas A. Veldhuis, Meritxell Canals, Dominique Massotte, Daniel P. Poole
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 465-483 (2020)
Background & Aims: Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potential target for novel analgesics and may drive the effects of the clinically approved drug eluxadoline for the treatment
Externí odkaz:
https://doaj.org/article/8f8f779f1b2f4f4d943c4c44b64c0667
Autor:
Sadia Alvi, Daniel P. Poole, Peter McIntyre, Scott Peng, Arisbel B. Gondin, Paulina D. Ramírez-García, Pradeep Rajasekhar, Larissa K. Dill, Simona E. Carbone, Thomas P. Davis, Felix Bennetts, Jeffri S. Retamal, Megan S. Grace, Juhura G. Almazi, Nicholas A. Veldhuis, Nigel W. Bunnett
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Endothelial and epithelial cells form physical barriers that modulate the exchange of fluid and molecules. The integrity of these barriers can be influenced by signaling through G protein-coupled receptors (GPCRs) and ion channels. Serotonin (5-HT) i
Autor:
Arthur Christopoulos, Daniel P. Poole, Pradeep Rajasekhar, Celine Valant, Meritxell Canals, Vi Pham, Ayame Saito, Rhian Alice Ceredig, Nicholas A. Veldhuis, Dominique Massotte, Simona E. Carbone, Jesse J. DiCello
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 465-483 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2020, 9 (3), pp.465-483. ⟨10.1016/j.jcmgh.2019.11.006⟩
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2020, 9 (3), pp.465-483. ⟨10.1016/j.jcmgh.2019.11.006⟩
Background & Aims: Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potential target for novel analgesics and may drive the effects of the clinically approved drug eluxadoline for the treatment
Autor:
Cameron J. Nowell, Thomas P. Davis, John F. Quinn, Michael R. Whittaker, Mai N. Vu, Daniel P. Poole, Song Yang Khor, Nicholas A. Veldhuis, Pradeep Rajasekhar, Nghia P. Truong
Publikováno v:
ACS Applied Nano Materials. 2:1844-1856
The development of nanoparticle-based targeted therapeutics for the treatment of cancer requires a well-defined understanding of the tumor microenvironment, which is challenging due to tumor complexity and heterogeneity. Recent advancements in three-
Autor:
Simona E. Carbone, Meritxell Canals, Pradeep Rajasekhar, Nicholas A. Veldhuis, Benjamin W. Sebastian, Ayame Saito, Rachel M McQuade, Jesse J. DiCello, Daniel P. Poole, Arisbel B. Gondin
Publikováno v:
Cellular and Molecular Life Sciences. 76:3033-3050
The use of opioid analgesics is severely limited due to the development of intractable constipation, mediated through activation of mu opioid receptors (MOR) expressed by enteric neurons. The related delta opioid receptor (DOR) is an emerging therape
Autor:
Daniel P. Poole, Daniela Vorkel, Juan Nunez-Iglesias, Suckert T, Eugene W. Myers, Akanksha Jain, Robert Haase, Stéphane Rigaud, Pradeep Rajasekhar, Talley J. Lambert, Pavel Tomancak
Modern life science relies heavily on fluorescent microscopy and subsequent quantitative bio-image analysis. The current rise of graphics processing units (GPUs) in the context of image processing enables batch processing large amounts of image data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fd2c6fb9d0b7c6289d4476a0ac1972f
https://doi.org/10.1101/2020.11.19.386565
https://doi.org/10.1101/2020.11.19.386565
Autor:
Shavonne Teng, Stephen Vanner, Alan Hegron, Jesse J. DiCello, Yang Yu, Josue Jaramillo-Polanco, Michelle L. Halls, Daniel P. Poole, Dane D. Jensen, Nicholas A. Veldhuis, Kam W. Leong, Nestor N. Jiménez-Vargas, Meritxell Canals, Brian L. Schmidt, Cintya Lopez-Lopez, Jing Gong, Alan E. Lomax, Simona E. Carbone, Matthew J. Wisdom, David E. Reed, Pradeep Rajasekhar, Nigel W. Bunnett, Rocco Latorre
Publikováno v:
Proc Natl Acad Sci U S A
Whether G protein-coupled receptors signal from endosomes to control important pathophysiological processes and are therapeutic targets is uncertain. We report that opioids from the inflamed colon activate δ-opioid receptors (DOPr) in endosomes of n