Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Pradeep M Joshi"'
Autor:
Sagen Flowers, Rushali Kothari, Yamila N Torres Cleuren, Melissa R Alcorn, Chee Kiang Ewe, Geneva Alok, Samantha L Fiallo, Pradeep M Joshi, Joel H Rothman
Publikováno v:
eLife, Vol 12 (2023)
The heteroplasmic state of eukaryotic cells allows for cryptic accumulation of defective mitochondrial genomes (mtDNA). ‘Purifying selection’ mechanisms operate to remove such dysfunctional mtDNAs. We found that activators of programmed cell deat
Externí odkaz:
https://doaj.org/article/7f877f324fdd41a2bb6a617247e8af68
Autor:
Yamila N Torres Cleuren, Chee Kiang Ewe, Kyle C Chipman, Emily R Mears, Cricket G Wood, Coco Emma Alma Al-Alami, Melissa R Alcorn, Thomas L Turner, Pradeep M Joshi, Russell G Snell, Joel H Rothman
Publikováno v:
eLife, Vol 8 (2019)
Innovations in metazoan development arise from evolutionary modification of gene regulatory networks (GRNs). We report widespread cryptic variation in the requirement for two key regulatory inputs, SKN-1/Nrf2 and MOM-2/Wnt, into the C. elegans endode
Externí odkaz:
https://doaj.org/article/ae1998556e3f4e91b5cbe8ea4e9c95dd
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c2f3dc7cd18d5721d6cbc49e8602cc7
https://doi.org/10.3791/64594
https://doi.org/10.3791/64594
Autor:
Chee Kiang Ewe, Erica M. Sommermann, Josh Kenchel, Sagen E. Flowers, Morris F. Maduro, Pradeep M. Joshi, Joel H. Rothman
Publikováno v:
Development. 149
The architecture of gene regulatory networks determines the specificity and fidelity of developmental outcomes. We report that the core regulatory circuitry for endoderm development in Caenorhabditis elegans operates through a transcriptional cascade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86489196c6e9ac0df168ccd170f33c81
https://doi.org/10.1242/dev.200337
https://doi.org/10.1242/dev.200337
An Autonomous Molecular Bioluminescent Reporter (AMBER) for voltage imaging in freely moving animals
Autor:
Jaclyn T. Eisdorfer, Sean McCotter, Luke Theogarajan, Prasanna Srinivasan, Pradeep M. Joshi, Nicole M Griffin, Mitra Saeidi, Dhananjay P. Thakur, Prajakta Kulkarni, Joel H. Rothman, Akshar Jain, Alex Nguyen-Le, Craig Montell
Publikováno v:
Adv Biol (Weinh)
1.AbstractGenetically encoded reporters have greatly increased our understanding of biology, especially in neuroscience. While fluorescent reporters have been widely used, photostability and phototoxicity have hindered their use in long-term experime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee07ef3992334928a84098c8af83a2d
https://europepmc.org/articles/PMC8858017/
https://europepmc.org/articles/PMC8858017/
Autor:
Johnny Habchi, Michele Vendruscolo, Sean Keng Rui Chia, Pradeep M. Joshi, Michele Perni, Xiuna Yang
Alzheimer’s disease is characterized by the presence in the brain of amyloid plaques formed by the aberrant deposition of the amyloid-β peptide (Aβ). Since many vitamins are dysregulated in this disease, we explored whether these molecules partic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2dcb28524d92eea0c79f0f11f7c4784
https://doi.org/10.1101/2021.10.30.466561
https://doi.org/10.1101/2021.10.30.466561
Autor:
Melissa R. Alcorn, Rushali Kothari, Chee Kiang Ewe, Geneva Alok, Yamila N. Torres Cleuren, Pradeep M. Joshi, Sagen E. Flowers, Joel H. Rothman
The heteroplasmic state of eukaryotic cells allows for cryptic accumulation of defective mitochondrial genomes (mtDNA). “Purifying selection” mechanisms operate to remove such dysfunctional mtDNAs. We found that activators of programmed cell deat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a523db0510d696e3151b50892d04db1
https://doi.org/10.1101/2021.10.27.466108
https://doi.org/10.1101/2021.10.27.466108
Autor:
Stephen Lantin, Xander Apicella, Alexander Cohen, Ghassan Akkad, Michael Waltemathe, Eliana Beltran-Pardo, Pradeep M. Joshi, Sophie Mendell, Emma McCoy, Prasanna Srinivasan, Philip Lubin, Joel H. Rothman
Publikováno v:
Acta Astronaut
Our ability to explore the cosmos by direct contact has been limited to a small number of lunar and interplanetary missions. However, the NASA Starlight program points a path forward to send small, relativistic spacecraft far outside our solar system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ee521f607969ad1c0b0f6987e5a3be
https://europepmc.org/articles/PMC9881496/
https://europepmc.org/articles/PMC9881496/
Autor:
Bilge Birsoy, Eric S Terry, Carl D. Meinhart, Pradeep M. Joshi, Marin Sigurdson, Joel H. Rothman, David Bothman
Despite a constant barrage of intrinsic and environmental noise, embryogenesis is remarkably reliable, suggesting the existence of systems that ensure faithful execution of this complex process. We report that earlyC. elegansembryos, which normally s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a363c4283b78505e42028e177e629d27
https://doi.org/10.1101/2020.06.02.128694
https://doi.org/10.1101/2020.06.02.128694
Publikováno v:
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Timely sister chromatid separation, promoted by separase, is essential for faithful chromosome segregation. Separase is a member of the CD clan of cysteine proteases, which also includes the pro-apoptotic enzymes known as caspases. We report a role f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a34924c44b9fe7df4c5a5e4b1ac0e9
https://escholarship.org/uc/item/6f63810t
https://escholarship.org/uc/item/6f63810t