Zobrazeno 1 - 10
of 1 355
pro vyhledávání: '"Pradeep J"'
Autor:
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin G. Tehan, Miles S. Congreve, Pradeep J. Nathan, Alastair J. H. Brown, Jack R. Mellor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
In this study, acetylcholine release is shown to reorganise hippocampal CA1 inhibitory networks resulting in prioritisation of entorhinal input over CA3 input. This is achieved by activation of a combination of M3 and M4 muscarinic receptors.
Externí odkaz:
https://doaj.org/article/6bc41c8173af451ba843ce9103cfc57b
Autor:
Charlotte Bakker, Tim Tasker, Jan Liptrot, Ellen P. Hart, Erica S. Klaassen, Robert Jan Doll, Giles A. Brown, Alastair Brown, Miles Congreve, Malcolm Weir, Fiona H. Marshall, David M. Cross, Geert Jan Groeneveld, Pradeep J. Nathan
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2021)
Abstract Background The cholinergic system and M1 receptor remain an important target for symptomatic treatment of cognitive dysfunction. The selective M1 receptor partial agonist HTL0018318 is under development for the symptomatic treatment of Demen
Externí odkaz:
https://doaj.org/article/8f25b2ca13ee46c9988b118de2ad5f58
Autor:
Pradeep J. Nathan, S. Babli Millais, Alex Godwood, Odile Dewit, David M. Cross, Janet Liptrot, Bharat Ruparelia, Stephen Paul Jones, Geor Bakker, Paul T. Maruff, Gregory A. Light, Alastair J.H. Brown, Malcolm Peter Weir, Miles Congreve, Tim Tasker
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild‐to‐moderate Alzheimer's disease (AD) on background donepezil 10 mg/day. M
Externí odkaz:
https://doaj.org/article/d2ea8035b82442a48e018eec2348acbe
Autor:
Rosemary A. Abbott, Caroline Skirrow, Martha Jokisch, Maarten Timmers, Johannes Streffer, Luc vanNueten, Michael Krams, Angela Winkler, Noreen Pundt, Pradeep J. Nathan, Philippa Rock, Francesca K. Cormack, Christian Weimar
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 36-44 (2019)
Abstract Introduction Normative cognitive data can help to distinguish pathological decline from normal aging. This study presents normative data from the Cambridge Neuropsychological Test Automated Battery, using linear regression and nonlinear quan
Externí odkaz:
https://doaj.org/article/ce4cd7f92aa64b51b50a40ec03bcd060
Autor:
Vishal Vashistha, Pradeep J Poonnen, Jane L Snowdon, Halcyon G Skinner, Victoria McCaffrey, Neil L Spector, Bradley Hintze, Jill E Duffy, Dilhan Weeraratne, Gretchen P Jackson, Michael J Kelley, Vimla L Patel
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235861 (2020)
BackgroundTo support the rising need for testing and to standardize tumor DNA sequencing practices within the U.S. Department of Veterans Affairs (VA)'s Veterans Health Administration (VHA), the National Precision Oncology Program (NPOP) was launched
Externí odkaz:
https://doaj.org/article/324e46e5f22d4783898c64979bb99f40
Autor:
Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin G. Tehan, Miles S. Congreve, Pradeep J. Nathan, Alastair J. H. Brown, Jack R. Mellor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/e8d149c342564fbcb1a1d42b3d13ea6d
Publikováno v:
Sultan Qaboos University Medical Journal, Vol 9, Iss 3, Pp 328-332 (2009)
Papillary carcinoma of thyroid usually presents as a palpable thyroid mass. This could be associated with pain, hoarseness, stridor or dysphagia. Rarely, it presents solely as cervical lympadenopthy in the presence of an otherwise grossly normal thyr
Externí odkaz:
https://doaj.org/article/cca6137b2408409eb855e54609b98ce9
Publikováno v:
Gastroenterology Research and Practice, Vol 2015 (2015)
Background. Choledochal cyst, a rare congenital cystic dilatation of biliary tree, is uncommon in adults. Their presentations differ from children and surgical management has evolved. Methods. A retrospective review of the records of all the patients
Externí odkaz:
https://doaj.org/article/efb15d298801455ebfe501e018d0f8e4
Autor:
Fruzsina Soltész, John Suckling, Phil Lawrence, Roger Tait, Cinly Ooi, Graham Bentley, Chris M Dodds, Sam R Miller, David R Wille, Misha Byrne, Simon M McHugh, Mark A Bellgrove, Rodney J Croft, Bai Lu, Edward T Bullmore, Pradeep J Nathan
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95558 (2014)
Increasing evidence suggests that synaptic dysfunction is a core pathophysiological hallmark of neurodegenerative disorders. Brain-derived neurotropic factor (BDNF) is key synaptogenic molecule and targeting synaptic repair through modulation of BDNF
Externí odkaz:
https://doaj.org/article/e33d779d8d374051b26737b203aa60e3
Autor:
Muzaffer Kaser, Fruzsina Soltesz, Phil Lawrence, Sam Miller, Chris Dodds, Rodney Croft, Robert B Dudas, Rashid Zaman, Emilio Fernandez-Egea, Ulrich Müller, Anna Dean, Edward T Bullmore, Pradeep J Nathan
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83255 (2013)
BACKGROUND: Impairments in mismatch negativity (MMN) generation have been consistently reported in patients with schizophrenia. However, underlying oscillatory activity of MMN deficits in schizophrenia and the relationship with cognitive impairments
Externí odkaz:
https://doaj.org/article/f9c5ff248c5b489c887ed722052cbd5b