The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation.

Autor: Duszczyk MM; Institute of Molecular Biology and Biophysics, ETH Zürich, 8093, Zürich, Switzerland. m.m.duszczyk@gmail.com., Wischnewski H; Institute of Molecular Health Sciences, ETH Zürich, 8093, Zürich, Switzerland., Kazeeva T; Institute of Molecular Biology and Biophysics, ETH Zürich, 8093, Zürich, Switzerland., Arora R; Institute of Molecular Health Sciences, ETH Zürich, 8093, Zürich, Switzerland., Loughlin FE; Institute of Molecular Biology and Biophysics, ETH Zürich, 8093, Zürich, Switzerland.; Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3800, VIC, Australia., von Schroetter C; Institute of Molecular Biology and Biophysics, ETH Zürich, 8093, Zürich, Switzerland.; Institute of Biochemistry, Department of Biology, ETH Zürich, 8093, Zürich, Switzerland., Pradère U; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland., Hall J; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland., Ciaudo C; Institute of Molecular Health Sciences, ETH Zürich, 8093, Zürich, Switzerland. cciaudo@ethz.ch., Allain FH; Institute of Molecular Biology and Biophysics, ETH Zürich, 8093, Zürich, Switzerland. allain@bc.biol.ethz.ch.; Institute of Biochemistry, Department of Biology, ETH Zürich, 8093, Zürich, Switzerland. allain@bc.biol.ethz.ch.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 06; Vol. 13 (1), pp. 5892. Date of Electronic Publication: 2022 Oct 06.

EGCG Disrupts the LIN28B/Let-7 Interaction and Reduces Neuroblastoma Aggressiveness.

Autor: Cocchi, Simona¹ (AUTHOR) simonacocchi90@gmail.com, Greco, Valentina¹ (AUTHOR) valentina.greco@unitn.it, Sidarovich, Viktoryia¹ (AUTHOR) viktoryia.sidarovich@unitn.it, Vigna, Jacopo^1,2 (AUTHOR) andrea.defant@ex-staff.unitn.it, Broso, Francesca¹ (AUTHOR), Corallo, Diana³ (AUTHOR), Zasso, Jacopo¹ (AUTHOR), Re, Angela¹ (AUTHOR), Rosatti, Emanuele Filiberto¹ (AUTHOR), Longhi, Sara¹ (AUTHOR), Defant, Andrea² (AUTHOR), Ladu, Federico⁴ (AUTHOR) fladu@uniss.it, Sanna, Vanna⁵ (AUTHOR), Adami, Valentina¹ (AUTHOR), D'Agostino, Vito G.¹ (AUTHOR), Sturlese, Mattia⁶ (AUTHOR) mattia.sturlese@unipd.it, Sechi, Mario⁴ (AUTHOR) mario.sechi@uniss.it, Aveic, Sanja³ (AUTHOR), Mancini, Ines² (AUTHOR), Sighel, Denise¹ (AUTHOR) denise.sighel@unitn.it

Publikováno v: International Journal of Molecular Sciences. May2024, Vol. 25 Issue 9, p4795. 21p.

Regulating Protein–RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway.

Autor: Oyejobi, Greater Kayode¹ (AUTHOR) greateroyejobi@whu.edu.cn, Yan, Xiaodan¹ (AUTHOR) yanxd09@whu.edu.cn, Sliz, Piotr² (AUTHOR) sliz@hkl.hms.harvard.edu, Wang, Longfei¹ (AUTHOR) sliz@hkl.hms.harvard.edu

Publikováno v: International Journal of Molecular Sciences. Apr2024, Vol. 25 Issue 7, p3585. 15p.

Towards Improved Oligonucleotide Therapeutics Through Faster Target Binding Kinetics.

Autor: Menzi M; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland., Wild B; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland., Pradère U; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland., Malinowska AL; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland., Brunschweiger A; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany., Lightfoot HL; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland., Hall J; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2017 Oct 12; Vol. 23 (57), pp. 14221-14230. Date of Electronic Publication: 2017 Sep 12.

Chemical synthesis of long RNAs with terminal 5'-phosphate groups.

Autor: Pradère U; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland., Halloy F; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland., Hall J; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2017 Apr 19; Vol. 23 (22), pp. 5210-5213. Date of Electronic Publication: 2017 Mar 29.