Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Prachi Stafford"'
Publikováno v:
Microorganisms, Vol 11, Iss 3, p 606 (2023)
Porphyromonas gingivalis contributes to the chronic oral disease periodontitis, triggering the activation of host inflammatory responses, inducing cellular stresses such as oxidation. During stress, host cells can activate the Integrated Stress Respo
Externí odkaz:
https://doaj.org/article/8f57dbf9c1cd4545a53a5f5f7acdd7af
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Host immune activation forms a vital line of defence against bacterial pathogenicity. However, just as hosts have evolved immune responses, bacteria have developed means to escape, hijack and subvert these responses to promote survival. In recent yea
Externí odkaz:
https://doaj.org/article/406bd6e683b049bbb45db03645c12941
Periodontitis, a chronic inflammatory gum disease, is caused in part by the periodontopathogen Porphyromonas gingivalis. Infection triggers activation of host inflammatory responses which induce stresses such as oxidative stress. Under such condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df46c1aa5032a557841797789fc0f036
https://doi.org/10.1101/2022.01.24.477647
https://doi.org/10.1101/2022.01.24.477647
Autor:
Kathryn L, Naylor, Magdalena, Widziolek, Stuart, Hunt, Mary, Conolly, Matthew, Hicks, Prachi, Stafford, Jan, Potempa, Craig, Murdoch, C W Ian, Douglas, Graham P, Stafford
Publikováno v:
MicrobiologyOpen
Outer membrane protein A (OmpA) is a key outer membrane protein found in Gram‐negative bacteria that contributes to several crucial processes in bacterial virulence. In Porphyromonas gingivalis, OmpA is predicted as a heterotrimer of OmpA1 and OmpA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fa18819f8dcbf56441a2c982a6c69d1
https://pubmed.ncbi.nlm.nih.gov/27595778
https://pubmed.ncbi.nlm.nih.gov/27595778
Autor:
C. W. Ian Douglas, Kiyonobu Honma, Ashu Sharma, Prachi Stafford, Sumita Roy, Chatchawal Phansopa, Graham P. Stafford
Publikováno v:
FEMS Immunology & Medical Microbiology. 65:116-120
Tannerella forsythia is an important pathogen in periodontal disease. Previously, we showed that its sialidase activity is key to utilization of sialic acid from a range of human glycoproteins for biofilm growth and initial adhesion. Removal of termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f9780fc312a630ce4f4cdbcd38310e
https://doi.org/10.1111/j.1574-695x.2012.00933.x
https://doi.org/10.1111/j.1574-695x.2012.00933.x
Autor:
Graham A. Smith, C. Proulx, Nicholas A. Watkins, Prachi Stafford, James A. Huntington, E. Ranasinghe, Cedric Ghevaert, Willem H. Ouwehand, K. Campbell, Lorna M. Williamson
Publikováno v:
Journal of Thrombosis and Haemostasis. 6:366-375
BACKGROUND - The single-nucleotide polymorphism (SNP) rs5918 in the ITGB3 gene defines the human platelet antigen-1 (HPA-1) system encoding a Leu (HPA-1a) or Pro (HPA-1b) at position 33. HPA-1 antibodies are clinically the most relevant in the Caucas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebe0fbb5119056ac48b9f8de3970e81e
https://doi.org/10.1111/j.1538-7836.2008.02858.x
https://doi.org/10.1111/j.1538-7836.2008.02858.x
Autor:
Prachi Stafford, Paul Metcalfe, M. Ann Benton, Graham A. Smith, Willem H. Ouwehand, Ian J. Harmer, Kate Campbell, Judith C.W. Marsh, Nicola S. Jennings
Publikováno v:
Transfusion. 47:499-510
BACKGROUND - Cold hemagglutinins are generally immunoglobulin M (IgM) kappa antibodies reactive at temperatures below 37 degrees C and if of high titer may cause hemolysis. Platelet (PLT) cold agglutinins (CAs) are rare and poorly characterized. A de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f78a74346a040ed184396a35bb172a
https://doi.org/10.1111/j.1537-2995.2006.01142.x
https://doi.org/10.1111/j.1537-2995.2006.01142.x
Autor:
Peter A. Smethurst, Prachi Stafford, Nicola S. Jennings, Jonathan Stephens, Stephen F. Garner, Richard W. Farndale, Lotta Joutsi-Korhonen, Nicholas A. Watkins, Marie N. O'Connor, Ian J. Harmer, C. Graham Knight, Willem H. Ouwehand
Publikováno v:
Journal of Immunological Methods. 316:75-83
We report the development of an expression system for the production of soluble, calmodulin (CaM)-tagged proteins in Drosophila Schneider S2 cells and the subsequent use of these proteins for the selection of phage displayed antibodies. The CaM-tag p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047be64fc57f0b9a7089a3b72971ba78
https://doi.org/10.1016/j.jim.2006.08.003
https://doi.org/10.1016/j.jim.2006.08.003
Autor:
G. A. Smith, Lorna M. Williamson, Willem H. Ouwehand, D. Allen, C. Gheveart, G. Lucas, Prachi Stafford, E. Ranasinghe, Paul Metcalfe, K. Campbell, Nicholas A. Watkins
Publikováno v:
ISBT Science Series. 1:96-102
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72aa0b6331dab6b6d25e1fa20c290104
https://doi.org/10.1111/j.1751-2824.2006.00020.x
https://doi.org/10.1111/j.1751-2824.2006.00020.x
Autor:
Samir W. Hamaia, Richard W. Farndale, Prachi Stafford, Anne Schoolmeester, Ian J. Harmer, Darren L. Hughes, Nicholas A. Watkins, Hans Deckmyn, Willem H. Ouwehand
Publikováno v:
Thrombosis and Haemostasis. 94:1318-1326
SummaryAntibodies are a powerful tool for structure/function studies of platelet proteins. However, classic immunisation frequently elicits antibody responses against domains of minor functional interest. Robust strategies to generate antibodies agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f3cd8c4ffc74042036b1cdbb9c1ec5e
https://doi.org/10.1160/th05-06-0410
https://doi.org/10.1160/th05-06-0410