Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Prachi, Kothiyal"'
Autor:
Hari Ilangovan, Prachi Kothiyal, Katherine A. Hoadley, Robin Elgart, Greg Eley, Parastou Eslami
Publikováno v:
npj Microgravity, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract NASA has employed high-throughput molecular assays to identify sub-cellular changes impacting human physiology during spaceflight. Machine learning (ML) methods hold the promise to improve our ability to identify important signals within hig
Externí odkaz:
https://doaj.org/article/39da41b7f01e4edd933e42973a4e7fff
Autor:
Prachi Kothiyal, Greg Eley, Hari Ilangovan, Katherine A. Hoadley, S. Robin Elgart, Xiao W. Mao, Parastou Eslami
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The space environment includes unique hazards like radiation and microgravity which can adversely affect biological systems. We assessed a multi-omics NASA GeneLab dataset where mice were hindlimb unloaded and/or gamma irradiated for 21 days
Externí odkaz:
https://doaj.org/article/8ed98ba55da94445a67f693e1a852a10
Autor:
Alper Uzun, Jessica S. Schuster, Joan Stabila, Valeria Zarate, George A. Tollefson, Anthony Agudelo, Prachi Kothiyal, Wendy S. W. Wong, James Padbury
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The likely genetic architecture of complex diseases is that subgroups of patients share variants in genes in specific networks sufficient to express a shared phenotype. We combined high throughput sequencing with advanced bioinformatic appro
Externí odkaz:
https://doaj.org/article/5d6630bb949d40938d091f25df301a7d
Autor:
Lauren M. Sanders, Ryan T. Scott, Jason H. Yang, Amina Ann Qutub, Hector Garcia Martin, Daniel C. Berrios, Jaden J. A. Hastings, Jon Rask, Graham Mackintosh, Adrienne L. Hoarfrost, Stuart Chalk, John Kalantari, Kia Khezeli, Erik L. Antonsen, Joel Babdor, Richard Barker, Sergio E. Baranzini, Afshin Beheshti, Guillermo M. Delgado-Aparicio, Benjamin S. Glicksberg, Casey S. Greene, Melissa Haendel, Arif A. Hamid, Philip Heller, Daniel Jamieson, Katelyn J. Jarvis, Svetlana V. Komarova, Matthieu Komorowski, Prachi Kothiyal, Ashish Mahabal, Uri Manor, Christopher E. Mason, Mona Matar, George I. Mias, Jack Miller, Jerry G. Myers, Charlotte Nelson, Jonathan Oribello, Seung-min Park, Patricia Parsons-Wingerter, R. K. Prabhu, Robert J. Reynolds, Amanda Saravia-Butler, Suchi Saria, Aenor Sawyer, Nitin Kumar Singh, Michael Snyder, Frank Soboczenski, Karthik Soman, Corey A. Theriot, David Van Valen, Kasthuri Venkateswaran, Liz Warren, Liz Worthey, Marinka Zitnik, Sylvain V. Costes
Publikováno v:
Nature Machine Intelligence. 5:208-219
Autor:
Ryan T. Scott, Lauren M. Sanders, Erik L. Antonsen, Jaden J. A. Hastings, Seung-min Park, Graham Mackintosh, Robert J. Reynolds, Adrienne L. Hoarfrost, Aenor Sawyer, Casey S. Greene, Benjamin S. Glicksberg, Corey A. Theriot, Daniel C. Berrios, Jack Miller, Joel Babdor, Richard Barker, Sergio E. Baranzini, Afshin Beheshti, Stuart Chalk, Guillermo M. Delgado-Aparicio, Melissa Haendel, Arif A. Hamid, Philip Heller, Daniel Jamieson, Katelyn J. Jarvis, John Kalantari, Kia Khezeli, Svetlana V. Komarova, Matthieu Komorowski, Prachi Kothiyal, Ashish Mahabal, Uri Manor, Hector Garcia Martin, Christopher E. Mason, Mona Matar, George I. Mias, Jerry G. Myers, Charlotte Nelson, Jonathan Oribello, Patricia Parsons-Wingerter, R. K. Prabhu, Amina Ann Qutub, Jon Rask, Amanda Saravia-Butler, Suchi Saria, Nitin Kumar Singh, Michael Snyder, Frank Soboczenski, Karthik Soman, David Van Valen, Kasthuri Venkateswaran, Liz Warren, Liz Worthey, Jason H. Yang, Marinka Zitnik, Sylvain V. Costes
Publikováno v:
Nature Machine Intelligence. 5:196-207
Autor:
Wendy S. W. Wong, Benjamin D. Solomon, Dale L. Bodian, Prachi Kothiyal, Greg Eley, Kathi C. Huddleston, Robin Baker, Dzung C. Thach, Ramaswamy K. Iyer, Joseph G. Vockley, John E. Niederhuber
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The study of germline mutations has been greatly enhanced by massive parallel sequencing technologies. Here the authors use deep sequencing data from nearly 700 parent-child trios to show maternal age has a small but significant correlation with the
Externí odkaz:
https://doaj.org/article/1d2fddf6abe04f2888ec30cf8d40ace3
Autor:
Wendy S.W. Wong, Joan P. Stabila, Jessica Schuster, Valeria Zarate, Prachi Kothiyal, James F. Padbury, Alper Uzun, George Tollefson, Anthony Agudelo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Scientific Reports
Scientific Reports
Rather than pathogenic variants in single genes, the likely genetic architecture of complex diseases is that subgroups of patients share variants in genes in specific networks and pathways sufficient to give rise to a shared phenotype. We combined hi
Autor:
Yuri Belayev, Victor Kryuchkov, Leandro M. Colli, Amy Berrington de Gonzalez, Maureen Hatch, Yosi Maruvka, Meredith Yeager, Chase W. Nelson, Mingyi Wang, Ivan Golovanov, Casey L. Dagnall, Bari J. Ballew, Vibha Vij, Nori Nakamura, Iryna Illienko, Paul S. Albert, Mark P. Little, Weiyin Zhou, Kiyohiko Mabuchi, Elena Bakhanova, Natalia Gudzenko, Shalabh Suman, Clara Bodelon, Vadim V. Chumak, Gad Getz, Stephen J. Chanock, Cameron D. Palmer, Chip Stewart, Lisa Mirabello, Neal D. Freedman, Vladimir Drozdovitch, Mitchell J. Machiela, Dimitry Bazyka, David Belyi, Prachi Kothiyal, Michael Dean, Elizabeth K. Cahoon, Amy Hutchinson
Publikováno v:
Science
Genomics of radiation-induced damage The potential adverse effects of exposures to radioactivity from nuclear accidents can include acute consequences such as radiation sickness, as well as long-term sequelae such as increased risk of cancer. There h
Autor:
Prachi Kothiyal, Grace Lawrence, Irma Godinez, Kathi Chesnutt Huddleston, Alma Fuller, Sahel Hazrati, Wendy Wong, John Deeken, John Niederhuber
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 27-27 (2019)
OBJECTIVES/SPECIFIC AIMS: This study aims to identify genetic biomarkers of GDM and facilitate the understanding of its molecular underpinnings. METHODS/STUDY POPULATION: We identified a cohort of mothers diagnosed with GDM in our longitudinal birth
Externí odkaz:
https://doaj.org/article/f6831fe69ead4d62ae462a033e23390b
Publikováno v:
Genetics in Medicine. 21:1240-1245
Clinical exome and gene panel testing can provide molecular diagnoses for patients with rare Mendelian disorders, but for many patients these tests are nonexplanatory. We investigated whether interrogation of alternative transcripts in known disease