Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Prabhjot Mundi"'
Autor:
Shaheer Khan, Sapna P. Patel, Alexander N. Shoushtari, Grazia Ambrosini, Serge Cremers, Shing Lee, Lauren Franks, Shahnaz Singh-Kandah, Susana Hernandez, Naomi Sender, Kristina Vuolo, Alexandra Nesson, Prabhjot Mundi, Benjamin Izar, Gary K. Schwartz, Richard D. Carvajal
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionUveal melanoma (UM) is associated with poor outcomes in the metastatic setting and harbors activating mutations resulting in upregulation of MAPK signaling in almost all cases. The efficacy of selumetinib, an oral allosteric inhibitor of
Externí odkaz:
https://doaj.org/article/06c02e4696264c518437de0b937c94fa
Autor:
Yongxin Chen, Filemon Dela Cruz, Romeil Sandhu, Andrew L. Kung, Prabhjot Mundi, Joseph O. Deasy, Allen Tannenbaum
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract In this note, we combined pediatric sarcoma data from Columbia University with adult sarcoma data collected from TCGA, in order to see if one can automatically discern a unique pediatric cluster in the combined data set. Using a novel cluste
Externí odkaz:
https://doaj.org/article/a79b7a3d0c4e4c8f9950c14e91f13336
Autor:
Harshraj Leuva, Mengxi Zhou, Norbert Brau, Sheldon T. Brown, Prabhjot Mundi, Ta-Chueh Melody Rosenberg, Carol Luhrs, Susan E. Bates, Yeun-Hee Anna Park, Tito Fojo
Publikováno v:
Seminars in oncology. 49(5)
Coronavirus disease 2019 (COVID-19) has been a constant health threat since its emergence. Amongst risk factors proposed, a diagnosis of cancer has been worrisome. We report the impact of cancer and other risk factors in US Veterans receiving care at
Autor:
Ester Calvo Fernández, Junqiang Wang, Aaron Griffin, Hanna Minns, Hong-Jian Wei, Xu Zhang, Luca Szalontay, Prabhjot Mundi, Cheng-Chia Wu, Robyn Gartrell, Stergios Zacharoulis, Andrea Califano, Jovana Pavisic
Publikováno v:
Neuro-Oncology. 24:i31-i32
Diffuse midline glioma (DMG) are fatal pediatric brain tumors with no effective systemic therapies. Molecular profiling demonstrates epigenetic dysregulation and heterogeneity, and novel approaches are needed to identify promising drugs and drug comb
Autor:
Daniel Diolaiti, Allison R. Rainey, Lianna J. Marks, Hajime Hosoi, Ladan Fazlollahi, Yasumichi Kuwahara, Filemon S. Dela Cruz, Andrea Califano, Darrell J. Yamashiro, Andrew L. Kung, Prabhjot Mundi, Yoshiki Katsumi, Ervin Gaviria
Malignant rhabdoid tumors (MRTs) are rare, aggressive pediatric solid tumors, characterized by a 22q11 deletion that inactivates the SMARCB1 gene. Outcomes remain poor despite multimodality treatment. MRTs are among the most genomically stable cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ea170fca02f1db84040ccef8bfc5008
https://doi.org/10.1101/2021.10.02.462793
https://doi.org/10.1101/2021.10.02.462793
Autor:
Angela L. Harris, Timothy P. Heffernan, Prabhjot Mundi, Shirong Cai, Sabrina Jeter-Jones, Joseph R. Marszalek, Gloria V. Echeverria, Alessandro Carugo, Sahil Seth, Xiaoyan Ma, Xinhui Zhou, Huan Qiu, Yun Wu, Andrea Califano, Jeffrey T. Chang, Michael Peoples, Yizheng Tu, Yuting Sun, Mariano J. Alvarez, Stacy L. Moulder, Zhongqi Ge, Xiaomei Zhang, Jiansu Shao, Vandhana Ramamoorthy, Helen Piwnica-Worms, Aaron McCoy, Qing Chang, Christopher A. Bristow, Rosanna Lau, William Fraser Symmans
Eradicating triple negative breast cancer (TNBC) resistant to neoadjuvant chemotherapy (NACT) is a critical unmet clinical need. In this study, patient-derived xenograft (PDX) models of treatment-naïve TNBC and serial biopsies from TNBC patients und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1b6fdb5fb8c374ed6a03be6865f479
https://europepmc.org/articles/PMC6541393/
https://europepmc.org/articles/PMC6541393/
Autor:
Jennifer E Amengual, Emily I. Chen, Neil L. Kelleher, Olivier Elemento, Prabhjot Mundi, Jennifer K. Lue, Nebiyu Abshiru, Jeannie M. Camarillo, Yulissa Gonzalez, Changhong Qiao, Serge Cremers, Sathyen A. Prabhu, Swasti Mehta, Renu Nandakumar, Akanksha Verma, Yuxuan Liu
Publikováno v:
Clin Cancer Res
Purpose: Both gain-of-function enhancer of zeste homolog 2 (EZH2) mutations and inactivating histone acetyltransferases mutations, such as CREBBP and EP300, have been implicated in the pathogenesis of germinal center (GC)–derived lymphomas. We hypo
Autor:
Kevin Kalinsky, Matthew J. Maurer, P Ananthakrishnan, DL Hershman, Katherine D. Crew, Sheldon Feldman, Lisa Wiechmann, B Taback, Eleni Andreopoulou, Emily I. Chen, Prabhjot Mundi, Joseph A. Sparano, Hanina Hibshoosh, Eileen P. Connolly
Publikováno v:
Cancer Research. 76:P3-07
Background: The PI3K/Akt/mTOR pathway is an important oncogenic driver in BC. A major hurdle in clinical Akt inhibitor development has been dose-limiting toxicities, such as rash. To facilitate the risk assessment of Akt inhibitor associated toxicity
Autor:
Andrea Califano, Armaan Siddiquee, Daniel Diolaiti, Andrew L. Kung, Prabhjot Mundi, Kristina Guillan, Michael V. Ortiz, Mahalaxmi Aburi, Filemon S. Dela Cruz, Lianna J. Marks, Daoqi You
Publikováno v:
Journal of Clinical Oncology. 38:3580-3580
3580 Background: XPO1 is a nuclear export protein that selectively transports tumor and growth regulatory proteins out of the nucleus, thereby effectively inhibiting their function. We previously utilized the Virtual Inference of Protein-activity by
Autor:
Melissa K. Accordino, Dawn L. Hershman, Prabhjot Mundi, Codruta Chiuzan, Kevin Kalinsky, Meghna S. Trivedi, Joseph A. Sparano, Francisco J. Esteva, Amy Tiersten, Andres Forero, Ruth O'Regan, Christos Vaklavas, Lea N. Baer, Sun Young Oh, Sarika Jain, Ingrid A. Mayer, Katherine D. Crew
Publikováno v:
Journal of Clinical Oncology. 35:TPS1112-TPS1112
TPS1112 Background: CDK4/6i, including palbociclib and ribociclib (R), have demonstrated remarkable benefit in progression free survival (PFS) in patients (pts) with HR+, HER2- MBC with anti-estrogen therapy. Switching between anti-estrogen therapies