GST fusion vector with caspase-6 cleavage site for removal of fusion tag during column purification

Autor: Prabhat Kumar Purbey, P. Cyril Jayakumar, P.D. Deepalakshmi, Milind S. Patole, Sanjeev Galande

Publikováno v: BioTechniques, Vol 38, Iss 3, Pp 360-366 (2005)

Externí odkaz: https://doaj.org/article/a4d0b7c0353d4e099c4395a90680d495

Abstract 2325: IRF1 displays opposing tumor cell-intrinsic and -extrinsic roles in anti-tumor immunity

Autor: Prabhat Kumar Purbey, Manash K. Paul, Keisuke S. Iwamoto, Allison Daly, Joowon Seo, Ameya S. Champhekar, Katie Campbell, Dorthe Schaue, William H. McBride, Steven M. Dubinett, Antoni Ribas, Stephen T. Smale, Philip O. Scumpia

Publikováno v: Cancer Research. 83:2325-2325

Interferons (IFNs), including IFN-α/β and IFN-γ, are multifaceted cytokines critical for antitumor immunity but contribute to T cell exhaustion through immune checkpoints. Recently, tumor cell expression of IRF1 was shown to enhance antitumor immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc5d0bb0e0b8b28ccbb96682603d3225
https://doi.org/10.1158/1538-7445.am2023-2325

Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense

Autor: Prabhat Kumar Purbey, Kindra M. Kelly-Scumpia, Amber Ruccia, Giovanni A. Botten, Stephen T. Smale, Philip O. Scumpia, Roberto Spreafico, Joshua S. Norman, Robert L. Modlin, Brandon J. Thomas

Publikováno v: PLoS pathogens, vol 13, iss 7
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 7, p e1006496 (2017)
Scumpia, Philip O; Botten, Giovanni A; Norman, Joshua S; Kelly-Scumpia, Kindra M; Spreafico, Roberto; Ruccia, Amber R; et al.(2017). Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense.. PLoS pathogens, 13(7), e1006496. doi: 10.1371/journal.ppat.1006496. UCLA: Retrieved from: http://www.escholarship.org/uc/item/42d5f298

Successful host defense against pathogens requires innate immune recognition of the correct pathogen associated molecular patterns (PAMPs) by pathogen recognition receptors (PRRs) to trigger the appropriate gene program tailored to the pathogen. Whil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1763d9a216b32e7720d32248aac561
https://escholarship.org/uc/item/42d5f298

PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1

Autor: Prabhat Kumar Purbey, Sunita Singh, Debashis Mitra, Sameet Mehta, K. N. Ganesh, Praveen Kumar, Sanjeev Galande

Publikováno v: Nucleic Acids Research

To better understand DNA recognition and transcription activity by SATB1, the T-lineage-enriched chromatin organizer and transcription factor, we have determined its optimal DNA-binding sequence by random oligonucleotide selection. The consensus SATB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9bef7623ce91901493c2ed266a95163
https://doi.org/10.1093/nar/gkm1151

Phosphorylation of SATB1, a Global Gene Regulator, Acts as a Molecular Switch Regulating Its Transcriptional Activity In Vivo

Autor: Prabhat Kumar Purbey, Sanjeev Galande, Amita Limaye, Chandan Kumar Sinha, Ranveer Singh Jayani, Praveen Kumar, Dimple Notani

Publikováno v: Molecular Cell. 22:231-243

SATB1 regulates gene expression by acting as a "docking site" for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters. However, how these contrasting effectors act at the level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14814a5a7cf1b5d3d7216efc9345c1c
https://doi.org/10.1016/j.molcel.2006.03.010