Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Prabhat Khadka"'
Autor:
Huiming Lu, Raghavendra A. Shamanna, Jessica K. de Freitas, Mustafa Okur, Prabhat Khadka, Tomasz Kulikowicz, Priscella P. Holland, Jane Tian, Deborah L. Croteau, Anthony J. Davis, Vilhelm A. Bohr
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
DNA double-strand break (DSB) repair is a tightly regulated process that can occur via non-homologous end joining (NHEJ) or homologous recombination (HR). Here, the authors investigate how RECQL4 modulates DSB repair pathway choice by differentially
Externí odkaz:
https://doaj.org/article/b07af637d9dc41b1aa40bd124f2fae2c
Autor:
Jack Freeland, Suresh Kumar Thallapuranam, Ryan Manso, Mason Ruiz, Ravi Kumar Gundampati, Prabhat Khadka, Asmaa A. Sadoon, Yong Wang, Jingyi Chen, Venkata Rao Krishnamurthi
Publikováno v:
Appl Environ Microbiol
The antimicrobial activity and mechanism of silver ions (Ag(+)) have gained broad attention in recent years. However, dynamic studies are rare in this field. Here, we report our measurement of the effects of Ag(+) ions on the dynamics of histone-like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40755bf71d2dbd5a899e98e04c48323b
https://doi.org/10.1128/aem.02479-19
https://doi.org/10.1128/aem.02479-19
Publikováno v:
Physical Review E. 98
We report our development of a simple and cost-effective method to amplify and probe the interactions of DNA with metal ions, which are important for various fundamental processes in living systems. This method is based on perturbing energy landscape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9627f5ed2defa22683bcd724c1e480cc
https://doi.org/10.1103/physreve.98.062403
https://doi.org/10.1103/physreve.98.062403
Autor:
Takashi Tadokoro, Aswin Mangerich, Raghavendra A. Shamanna, Joseph K. Hsu, Sebastian Veith, Deborah L. Croteau, Prabhat Khadka, Vilhelm A. Bohr
Publikováno v:
Molecular and Cellular Biology. 35:3974-3989
Poly(ADP-ribose) (PAR) polymerase 1 (PARP1) catalyzes the poly(ADP-ribosyl)ation (PARylation) of proteins, a posttranslational modification which forms the nucleic acid-like polymer PAR. PARP1 and PAR are integral players in the early DNA damage resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367c19ddebf7bef3adb964bd630d9c05
https://doi.org/10.1128/mcb.00427-15
https://doi.org/10.1128/mcb.00427-15
Autor:
Anthony J. Davis, Jessica K De Freitas, Tomasz Kulikowicz, Prabhat Khadka, Huiming Lu, Vilhelm A. Bohr, Raghavendra A. Shamanna, Deborah L. Croteau, Priscella P. Holland, Mustafa Nazir Okur, Jane Tian
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Pathway choice within DNA double-strand break (DSB) repair is a tightly regulated process to maintain genome integrity. RECQL4, deficient in Rothmund-Thomson Syndrome, promotes the two major DSB repair pathways, non-homologous end joining (NHEJ) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462c2481d5aad0e507c9ab918d5d01d0
http://europepmc.org/articles/PMC5725494
http://europepmc.org/articles/PMC5725494
Publikováno v:
Nucleic Acids Research
Telomerase, a unique ribonucleoprotein complex that contains the telomerase reverse transcriptase (TERT), the telomerase RNA component (TERC) and the TERC-binding protein dyskerin, is required for continued cell proliferation in stem cells and cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0e5503ce936205f6a1b8603f2896f3
https://doi.org/10.1093/nar/gkv844
https://doi.org/10.1093/nar/gkv844
Autor:
Jeong Seok Cha, Hyun Soo Cho, Sun Ah Jeong, Kuglae Kim, Prabhat Khadka, Ji Hoon Lee, In Kwon Chung
Publikováno v:
Journal of Cell Science. 128:2287-2301
Telomeres are essential for chromosome integrity and protection, and their maintenance requires the ribonucleoprotein enzyme telomerase. Previously, we have shown that human telomerase reverse transcriptase (hTERT) contains a bipartite nuclear locali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545672330fb66820408a0cce6b5bf5de
https://doi.org/10.1242/jcs.166132
https://doi.org/10.1242/jcs.166132
Autor:
Deborah L. Croteau, Prabhat Khadka, Yie Liu, Joseph K. Hsu, Kent Horvath, Vilhelm A. Bohr, Venkateswarlu Popuri
Publikováno v:
Nucleic Acids Research
A variety of human tumors employ alternative and recombination-mediated lengthening for telomere maintenance (ALT). Human RecQ helicases, such as BLM and WRN, can efficiently unwind alternate/secondary structures during telomere replication and/or re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae199bcc8ec5dd60f28913ff1f85000
https://doi.org/10.1093/nar/gku200
https://doi.org/10.1093/nar/gku200
Autor:
Prabhat Khadka, Meaad Alqahtany, Jingyi Chen, Sai Divya Challapalli, Asmaa A. Sadoon, Yong Wang, Venkata Rao Krishnamurthi, Isabelle I. Niyonshuti
Publikováno v:
Nanotechnology. 30:385101
Silver nanoparticles (AgNPs) and ions (Ag+) have recently gained broad attention due to their antimicrobial effects against bacteria and other microbes. In this work, we demonstrate the use of super-resolution fluorescence microscopy for investigatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f812fd5d3664d139815bcdc257ec28e
https://doi.org/10.1088/1361-6528/ab2a9f
https://doi.org/10.1088/1361-6528/ab2a9f
Publikováno v:
Histochemistry and Cell Biology. 141:137-152
The maintenance of human telomeres requires the ribonucleoprotein enzyme telomerase, which is composed of telomerase reverse transcriptase (TERT), telomerase RNA component, and several additional proteins for assembly and activity. Telomere elongatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b032853be7605333943d821a19ccf08c
https://doi.org/10.1007/s00418-013-1166-x
https://doi.org/10.1007/s00418-013-1166-x