Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Prabhat K. Ghosh"'
Publikováno v:
Journal of Neurophysiology. 95:1656-1668
The paraventricular thalamic nucleus (PVT) receives one of the most dense innervations by hypothalamic hypocretin/orexin (Hcrt) neurons, which play important roles in sleep-wakefulness, attention, and autonomic function. The PVT projects to several l
Publikováno v:
Neuron. 42(4):635-652
Neurons that synthesize melanin-concentrating hormone (MCH) may modulate arousal and energy homeostasis. The scattered MCH neurons have been difficult to study, as they have no defining morphological characteristics. We have developed a viral approac
Autor:
Xiao-Bing Gao, Anthony N. van den Pol, Prabhat K. Ghosh, George K. Aghajanian, Ying Li, Rong-Jian Liu
Publikováno v:
The Journal of Physiology. 541:169-185
The noradrenergic neurons of the locus coeruleus (LC) play an important role in modulating arousal and selective attention. A similar function has been attributed to the hypocretin neurons of the hypothalamus which maintain a strong synaptic projecti
Publikováno v:
The Journal of Comparative Neurology. 433:349-363
Hypocretin is a recently discovered peptide that is synthesized by neurons in the lateral hypothalamic area (LH) and is believed to play a role in sleep regulation, arousal, endocrine control, and food intake. These functions are critical for the dev
Autor:
Prabhat K. Ghosh, AN van den Pol
Publikováno v:
The Journal of Neuroscience. 18:10640-10651
In simple nervous systems, identified groups of neurons can be studied in depth. To allow the same advantage in the mammalian brain, we have generated green fluorescent protein (GFP) transgenic mice in which only a few types of neurons are strongly l
Publikováno v:
The Journal of Neuroscience. 18:10749-10761
In contrast to the mature brain, in which GABA is the major inhibitory neurotransmitter, in the developing brain GABA can be excitatory, leading to depolarization, increased cytoplasmic calcium, and action potentials. We find in developing hypothalam
Publikováno v:
Developmental Brain Research. 102:1-12
Previous studies have demonstrated the critical role glutamate plays in the hypothalamus, both in the developing and adult brain. The expression of metabotropic glutamate receptor (mGluR) mRNA (mGluR1-8) was studied in the suprachiasmatic (SCN) and a
Publikováno v:
Journal of Biological Chemistry. 269:32886-32895
L1 is a developmentally regulated adhesion molecule that may play a role in some aspects of axonal guidance. With Northern blots we find peak expression of L1 RNA at postnatal day 1 (P1) in the developing rat brain. Western blots show a peak of prote
Publikováno v:
The Journal of Comparative Neurology. 347:455-469
VGF is a neuronal polypeptide first identified as a cDNA clone in a gene library from nerve growth factor-stimulated PC12 cells. In the present paper, the expression of VGF is examined for the first time throughout the adult rat central nervous syste
Publikováno v:
The Journal of Comparative Neurology. 343:428-444
In situ hybridization and Northern blots were used to study the ionotropic subtypes of the glutamate receptor in the rat hypothalamus. Widespread expression of AMPA, kainate, and NMDA receptor RNA was found in the hypothalamus with the transcripts th