Anticoagulation Strategies in Non–Critically Ill Patients with Covid-19

Autor: Zoe K. McQuilten, Balasubramanian Venkatesh, Vivekanand Jha, Jason Roberts, Susan C. Morpeth, James A. Totterdell, Grace M. McPhee, John Abraham, Niraj Bam, Methma Bandara, Ashpak K. Bangi, Lauren A. Barina, Bhupendra K. Basnet, Hasan Bhally, Khema R. Bhusal, Umesh Bogati, Asha C. Bowen, Andrew J. Burke, Devasahayam J. Christopher, Sanjeev D. Chunilal, Belinda Cochrane, Jennifer L. Curnow, Santa Kumar Das, Ashesh Dhungana, Gian Luca Di Tanna, Ravindra Dotel, Hyjel DSouza, Jack Dummer, Sourabh Dutta, Hong Foo, Timothy L. Gilbey, Michelle L. Giles, Kasiram Goli, Adrienne Gordon, Pradip Gyanwali, Dipak Haksar, Bernard J. Hudson, Manoj K. Jani, Purnima R. Jevaji, Sachin Jhawar, Aikaj Jindal, M. Joseph John, Mary John, Flavita B. John, Oommen John, Mark Jones, Rajesh D. Joshi, Prashanthi Kamath, Gagandeep Kang, Achyut R. Karki, Abhishek M. Karmalkar, Baldeep Kaur, Kalyan Chakravarthy Koganti, Jency M. Koshy, Mathew S. Krishnamurthy, Jillian S. Lau, Sharon R. Lewin, Lyn-li Lim, Ian C. Marschner, Julie A. Marsh, Michael J. Maze, James M. McGree, James H. McMahon, Robert L. Medcalf, Eileen G. Merriman, Amol P. Misal, Jocelyn M. Mora, Vijaybabu K. Mudaliar, Vi Nguyen, Matthew V. O’Sullivan, Suman Pant, Pankaj Pant, David L. Paterson, David J. Price, Megan A. Rees, James O. Robinson, Benjamin A. Rogers, Sandhya Samuel, Joe Sasadeusz, Deepak Sharma, Prabhat K. Sharma, Roshan Shrestha, Sailesh K. Shrestha, Prajowl Shrestha, Urvi Shukla, Omar Shum, Christine Sommerville, Tim Spelman, Richard P. Sullivan, Umashankar Thatavarthi, Huyen A. Tran, Nanette Trask, Clare L. Whitehead, Robert K. Mahar, Naomi E. Hammond, James D. McFadyen, Thomas L. Snelling, Joshua S. Davis, Justin T. Denholm, Steven Y.C. Tong

Publikováno v: NEJM Evidence. 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b87130ec85d6dbbc35f1fa26838b042
https://doi.org/10.1056/evidoa2200293

Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells

Autor: Michelle E. Leonard, Carole Le Coz, Annabel Torres, Struan F.A. Grant, Rajan M. Thomas, Chun Su, Kenyaita M. Hodge, Elisabetta Manduchi, Neil Romberg, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Sumei Lu, Parul Mehra, Prabhat K. Sharma, James A. Pippin

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications

Systemic lupus erythematosus (SLE) is mediated by autoreactive antibodies that damage multiple tissues. Genome-wide association studies (GWAS) link >60 loci with SLE risk, but the causal variants and effector genes are largely unknown. We generated h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20daf8f18d9fe7569e1dc0a99fb61a81
https://doi.org/10.1038/s41467-020-17089-5

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis

Autor: Prinita Baijnath, Leon Naidoo, Eisa Mahyari, Bongiwe Z. Xulu, Kelly L. Miners, William R. Bishai, Umesh G. Lalloo, Morten Nielsen, Moosa Suleman, Victoria O. Kasprowicz, Rajhmun Madansein, Thumbi Ndung'u, Prabhat K. Sharma, Erin W. Meermeier, David M. Lewinsohn, David Price, Aneta H. Worley, Sharon Khuzwayo, Emily B. Wong, Marielle C. Gold, Zoe Rogers, Zuri A. Sullivan, Alasdair Leslie, Henrik N. Kløverpris, James E. McLaren, Kristin Ladell, Samuel M. Behar, Anish Ambaram

Publikováno v: Communications Biology
Wong, E B, Gold, M C, Meermeier, E W, Xulu, B Z, Khuzwayo, S, Sullivan, Z A, Mahyari, E, Rogers, Z, Kløverpris, H, Sharma, P K, Worley, A H, Lalloo, U, Baijnath, P, Ambaram, A, Naidoo, L, Suleman, M, Madansein, R, McLaren, J E, Ladell, K, Miners, K L, Price, D A, Behar, S M, Nielsen, M, Kasprowicz, V O, Leslie, A, Bishai, W R, Ndung'u, T & Lewinsohn, D M 2019, ' TRAV1-2 + CD8 + T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis ', Communications Biology, vol. 2, 203 . https://doi.org/10.1038/s42003-019-0442-2
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Wong, E B, Gold, M C, Meermeier, E W, Xulu, B Z, Khuzwayo, S, Sullivan, Z A, Mahyari, E, Rogers, Z, Kløverpris, H, Sharma, P K, Worley, A H, Lalloo, U, Baijnath, P, Ambaram, A, Naidoo, L, Suleman, M, Madansein, R, McLaren, J E, Ladell, K, Miners, K L, Price, D A, Behar, S M, Nielsen, M, Kasprowicz, V O, Leslie, A, Bishai, W R, Ndung’u, T & Lewinsohn, D M 2019, ' TRAV1-2 + CD8 + T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis ', Communications Biology, vol. 2, no. 1, 203 . https://doi.org/10.1038/s42003-019-0442-2

Mucosal-associated invariant T (MAIT) cells typically express a TRAV1-2+ semi-invariant TCRα that enables recognition of bacterial, mycobacterial, and fungal riboflavin metabolites presented by MR1. MAIT cells are associated with immune control of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4817cecf805d1a194b666c2f42cd6a6b

Circulating Mycobacterium tuberculosis DosR latency antigen-specific, polyfunctional, regulatory IL10(+) Th17 CD4 T-cells differentiate latent from active tuberculosis

Autor: Greg Finak, Chirag Dhar, Pravat Nalini Sahoo, Annapurna Vyakarnam, Srabanti Rakshit, J Anto Jesuraj Uk, Prabhat K. Sharma, George D. Souza, Krista E. van Meijgaarden, Soumya Nayak, Vasista Adiga, Tom H. M. Ottenhoff, Stephen C. De Rosa

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports, 7
Rakshit, S, Adiga, V, Nayak, S, Sahoo, P N, Sharma, P K, Van Meijgaarden, K E, Uk J., A J, Dhar, C, Souza, G D, Finak, G, De Rosa, S C, Ottenhoff, T H M & Vyakarnam, A 2017, ' Circulating Mycobacterium tuberculosis DosR latency antigen-specific, polyfunctional, regulatory IL10+ Th17 CD4 T-cells differentiate latent from active tuberculosis ', Scientific Reports, vol. 7, no. 1, 11948 . https://doi.org/10.1038/s41598-017-10773-5

The functional heterogeneity of T cell responses to diverse antigens expressed at different stages of Mycobacterium tuberculosis (Mtb) infection, in particular early secreted versus dormancy related latency antigens expressed later, that distinguish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eadc5132e97b82dadd134bcdeedcfcc
https://hdl.handle.net/1887/115091

Role of CXCR3+CCR5+ Th1 cells in pulmonary tuberculosis patients: At pathogenic site

Autor: Prabhat K. Sharma, Binit Kumar Singh, Chaitenya Verma, P. K. Saha

Publikováno v: Biomedical and Biotechnology Research Journal, Vol 3, Iss 2, Pp 80-86 (2019)

Objective: Tuberculosis (TB) still remains a major global public health problem followed by drug-resistant TB. Understanding of deeper immunopathogenesis into the pathogen–host interactions is required so that it can be translated into effective to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db6507be34c3410a2739d4054bfc0cb
https://doi.org/10.4103/bbrj.bbrj_78_19