Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Prabhash Nath Tripathi"'
Publikováno v:
Health Sciences Review, Vol 11, Iss , Pp 100172- (2024)
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and epilepsy sickness, currently impact millions of people globally. Thus yet, the primary etiology of these ailments has not been de
Externí odkaz:
https://doaj.org/article/8d0a7264f970439ea466b756a384a0a6
Autor:
Abdel-Nasser El-Shorbagi, Sachin Chaudhary, Anurag Chaudhary, Garima Agarwal, Prabhash Nath Tripathi, Shweta Dumoga
Publikováno v:
Biomedical and Pharmacology Journal. 15:1797-1819
β-lactam antibiotics are considered the safest bactericides, and upon wide clinical use of benzyl penicillin G in 1945, outbreaks of resistance came out. The frequent semi-synthetic strategies revealed β-lactam generations that are of broad-spectru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fa86fbdfe4d26589916894094b8fc4f
https://doi.org/10.13005/bpj/2519
https://doi.org/10.13005/bpj/2519
Autor:
Sachin Chaudhary, Abdel-Nasser El-Shorbagi, Anurag Chaudhary, Garima Agarwal, Prabhash Nath Tripathi, Shweta Dumoga
Publikováno v:
Biomedical and Pharmacology Journal. 15:1201-1211
The coronavirus 2 illness (Covid-19) global pandemic has resulted in severe infection causing fever, cough, shortness of breath, pneumonia and even death. WHO is monitoring intimately in coordination with scientific experts and government agencies, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdac34569cbd7a7a4653606406f4dceb
https://doi.org/10.13005/bpj/2456
https://doi.org/10.13005/bpj/2456
Autor:
Sushant Kumar Shrivastava, Ojaswi Sinha, Munish Kumar, Digambar Kumar Waiker, Akash Verma, Prabhash Nath Tripathi, Bhagwati Bhardwaj, Poorvi Saraf
Publikováno v:
Medicinal Chemistry Research. 31:1594-1610
In our present work some novel substituted 4-phenyl-5-vinylpyrrolidin-2-one derivatives were designed, synthesized, and evaluated for their γ-aminobutyric acid-aminotransferase (GABA-AT) inhibition and in-vivo anticonvulsant activity. Among all the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d9501f931ed42011e0cf8809d6fb93
https://doi.org/10.1007/s00044-022-02935-6
https://doi.org/10.1007/s00044-022-02935-6
Autor:
Abdel-Nasser El-Shorbagi, Sachin Chaudhary, Anurag Chaudhary, Garima Agarwal, Prabhash Nath Tripathi, Shweta Dumoga, Alaa Ali Aljarad, Fatma Mahmoud, Esraa Omer, Ramesh Kumar Gupta, Mahmoud Hamed Mohamed
Publikováno v:
Biomedical and Pharmacology Journal. 15:579-603
Aquatic environment is one of the important sources of active agents that own diverse biological properties. Metabolites from these sources are considered as alternate source to meet the mandate for effective medicines. Despite notable developments i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc96017dbd54d825b7a270b0ae997065
https://doi.org/10.13005/bpj/2398
https://doi.org/10.13005/bpj/2398
Autor:
Surya Pratap Singh, Avanish Tripathi, Saumitra Sen Singh, Sushant K. Shrivastava, Piyoosh Sharma, Prabhash Nath Tripathi
Publikováno v:
ACS Chemical Neuroscience. 10:4361-4384
Multitargeted hybrids of N-benzylpiperidine and substituted 5-phenyl-1,3,4-oxadiazoles were designed, synthesized, and evaluated against Alzheimer’s disease (AD). Tested compounds exhibited moderat...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b4a4d649caf12098dca1da86cf0fca5
https://doi.org/10.1021/acschemneuro.9b00430
https://doi.org/10.1021/acschemneuro.9b00430
Autor:
Sachchida Nand Rai, Sushant K. Shrivastava, Piyoosh Sharma, Pavan Srivastava, Manish Kumar Tripathi, Surya Pratap Singh, Ankit Seth, Avanish Tripathi, Prabhash Nath Tripathi
Publikováno v:
Bioorganic Chemistry. 85:82-96
A series of novel piperazine tethered biphenyl-3-oxo-1,2,4-triazine derivatives were designed, and synthesized. Amongst the synthesized analogs, compound 6g showed significant non-competitive inhibitory potential against acetylcholinesterase (AChE, I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8895521d1054848644cc223047706b17
https://doi.org/10.1016/j.bioorg.2018.12.017
https://doi.org/10.1016/j.bioorg.2018.12.017
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:1327-1340
Novel hybrids bearing a 2-aminopyrimidine (2-AP) moiety linked to substituted 1,3,4-oxadiazoles were designed, synthesized and biologically evaluated. Among the developed compounds, 28 noncompetitively inhibited human acetylcholinesterase (hAChE; pIC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58c1d568a105bb21e855e07b33701dd
https://doi.org/10.1016/j.bmc.2019.02.031
https://doi.org/10.1016/j.bmc.2019.02.031
Autor:
Sushant K. Shrivastava, Pavan Srivastava, Ankit Seth, Anupam G. Banerjee, Piyoosh Sharma, Prabhash Nath Tripathi
Publikováno v:
Progress in Neurobiology. 174:53-89
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an aging population worldwide. The enormous challenge which AD possesses to global healthcare makes it as urgent as ever for the researchers to develop innovative treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b768e8d54bf71b8c0a34f6ed62201e
https://doi.org/10.1016/j.pneurobio.2018.12.006
https://doi.org/10.1016/j.pneurobio.2018.12.006
Autor:
Sachchida Nand Rai, Sharmila Shankar, Sushant K. Shrivastava, Prabhash Nath Tripathi, Pavan Srivastava, Piyoosh Sharma, Rakesh K. Srivastava, Surya Pratap Singh
Publikováno v:
European Journal of Medicinal Chemistry. 163:116-135
Based on the Gaussian-based quantitative structure-activity relationship (QSAR) and virtual screening (VS) processes, some promising acetylcholinesterase inhibitors (AChEIs) having antioxidant potential were designed synthesized, characterized, and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a448d19ad8f09b600128a3e1dc9d73e4
https://doi.org/10.1016/j.ejmech.2018.11.049
https://doi.org/10.1016/j.ejmech.2018.11.049