Zobrazeno 1 - 10
of 262
pro vyhledávání: '"Prabhas V. Moghe"'
Autor:
Hoda M. Gebril, Aravind Aryasomayajula, Mariana Reis Nogueira de Lima, Kathryn E. Uhrich, Prabhas V. Moghe
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-24 (2024)
Abstract Background Alzheimer's disease (AD) is considered to have a multifactorial etiology. The hallmark of AD is progressive neurodegeneration, which is characterized by the deepening loss of memory and a high mortality rate in the elderly. The ne
Externí odkaz:
https://doaj.org/article/e928cd5e312a460dbc51d678e149f4ad
Autor:
Jay V. Shah, Jake N. Siebert, Xinyu Zhao, Shuqing He, Richard E. Riman, Mei Chee Tan, Mark C. Pierce, Edmund C. Lattime, Vidya Ganapathy, Prabhas V. Moghe
Publikováno v:
Advanced NanoBiomed Research, Vol 4, Iss 2, Pp n/a-n/a (2024)
Checkpoint immunotherapy has made great strides in the treatment of solid tumors, but many patients do not respond to immune checkpoint inhibitors. Identification of tumor‐infiltrating cytotoxic T cells (CTLs) has the potential to stratify patients
Externí odkaz:
https://doaj.org/article/6ff9a503f8e04be3a60f79bc1b94337b
Autor:
Jake N. Siebert, Jay V. Shah, Mei Chee Tan, Richard E. Riman, Mark C. Pierce, Edmund C. Lattime, Vidya Ganapathy, Prabhas V. Moghe
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 549 (2024)
Metastatic breast cancer remains a significant source of mortality amongst breast cancer patients and is generally considered incurable in part due to the difficulty in detection of early micro-metastases. The pre-metastatic niche (PMN) is a tissue m
Externí odkaz:
https://doaj.org/article/d03fbf3ae8654865ae2fee172eeb626c
Autor:
Nanxia Zhao, Nicola L. Francis, Shuang Song, Vladyslav Kholodovych, Hannah R. Calvelli, Cody L. Hoop, Zhiping P. Pang, Jean Baum, Kathryn E. Uhrich, Prabhas V. Moghe
Publikováno v:
Advanced NanoBiomed Research, Vol 2, Iss 6, Pp n/a-n/a (2022)
Neuroinflammation is one of the hallmarks contributing to Parkinson's disease (PD) pathology, where microglial activation occurs as one of the earliest events, triggered by extracellular α‐synuclein (aSYN) binding to the cluster of differentation
Externí odkaz:
https://doaj.org/article/007e78eb32184889a57cd6cfc2c2c854
Autor:
Harini Kantamneni, Shravani Barkund, Michael Donzanti, Daniel Martin, Xinyu Zhao, Shuqing He, Richard E. Riman, Mei Chee Tan, Mark C. Pierce, Charles M. Roth, Vidya Ganapathy, Prabhas V. Moghe
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background The ability to detect tumor-specific biomarkers in real-time using optical imaging plays a critical role in preclinical studies aimed at evaluating drug safety and treatment response. In this study, we engineered an imaging platfo
Externí odkaz:
https://doaj.org/article/091eadecce2e4820b5d5a8a40f42e087
Autor:
Amber Gonda, Nanxia Zhao, Jay V. Shah, Jake N. Siebert, Srujanesh Gunda, Berk Inan, Mijung Kwon, Steven K. Libutti, Prabhas V. Moghe, Nicola L. Francis, Vidya Ganapathy
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundLate-stage diagnosis of ovarian cancer, a disease that originates in the ovaries and spreads to the peritoneal cavity, lowers 5-year survival rate from 90% to 30%. Early screening tools that can: i) detect with high specificity and sensitiv
Externí odkaz:
https://doaj.org/article/4f7534a0ee9e4be0952e2d43d5e9bfdc
Autor:
Jay V. Shah, Amber Gonda, Rahul Pemmaraju, Aishwarya Subash, Carolina Bobadilla Mendez, Marissa Berger, Xinyu Zhao, Shuqing He, Richard E. Riman, Mei Chee Tan, Mark C. Pierce, Prabhas V. Moghe, Vidya Ganapathy
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Therapeutic drug monitoring (TDM) in cancer, while imperative, has been challenging due to inter-patient variability in drug pharmacokinetics. Additionally, most pharmacokinetic monitoring is done by assessments of the drugs in plasma, which is not a
Externí odkaz:
https://doaj.org/article/103a1d60a69d46f4b02fa83250ec6e31
Publikováno v:
APL Bioengineering, Vol 4, Iss 3, Pp 030902-030902-16 (2020)
Advances in nanotechnology have enabled the design of nanotherapeutic platforms that could address the challenges of targeted delivery of active therapeutic agents to the central nervous system (CNS). While the majority of previous research studies o
Externí odkaz:
https://doaj.org/article/715727c0a8704aa4aec9fc4c920572fd
Autor:
Nanxia Zhao, Xue Yang, Hannah R. Calvelli, Yue Cao, Nicola L. Francis, Rebecca A. Chmielowski, Laurie B. Joseph, Zhiping P. Pang, Kathryn E. Uhrich, Jean Baum, Prabhas V. Moghe
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Parkinson’s Disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, the extracellular accumulation of toxic α-synuclein (αSYN) aggregates, and neuroinflammation. Microglia, resident macrophages of the b
Externí odkaz:
https://doaj.org/article/3bb405a61ac14e20ae817ef265871266
Numerical Modeling in Biomedical Engineering brings together the integrative set of computational problem solving tools important to biomedical engineers. Through the use of comprehensive homework exercises, relevant examples and extensive case studi
