Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Prabhani U. Atukorale"'
Autor:
Yu-Sang Sabrina Yang, Prabhani U. Atukorale, Kelly D. Moynihan, Ahmet Bekdemir, Kavya Rakhra, Li Tang, Francesco Stellacci, Darrell J. Irvine
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Assessing nanomaterials at the single cell level has proven to be complicated due to the limitations of existing techniques. Here, the authors utilised single-cell mass cytometry by time-of-flight as a label-free technique to analyse nanoparticle dis
Externí odkaz:
https://doaj.org/article/6999926d3b0d49899d6ed81323f2cbf6
Autor:
Efstathios Karathanasis, Christopher J. Hoimes, Gil Covarrubias, Amy L. Goldberg, Michelle L. Wiese, Peter A. Bielecki, Carolyn Zheng, Taylor J. Moon, Vanitha Raguveer, Shruti P. Raghunathan, Prabhani U. Atukorale
Effective cancer immunotherapy depends on the robust activation of tumor-specific antigen-presenting cells (APC). Immune agonists encapsulated within nanoparticles (NP) can be delivered to tumor sites to generate powerful antitumor immune responses w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d953fd927d7e3365101de9fd76746975
https://doi.org/10.1158/0008-5472.c.6510899.v1
https://doi.org/10.1158/0008-5472.c.6510899.v1
Autor:
Efstathios Karathanasis, Christopher J. Hoimes, Gil Covarrubias, Amy L. Goldberg, Michelle L. Wiese, Peter A. Bielecki, Carolyn Zheng, Taylor J. Moon, Vanitha Raguveer, Shruti P. Raghunathan, Prabhani U. Atukorale
SF1: IFNβ production from macrophages by ELISA analysis; SF2: FMT imaging of mammary tumors ex vivo for spatial localization of nanoparticle; SF3: Confocal micrographs of DiI-nanoparticle fluorescence in mammary tumor tissue; SF4: Representative ima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac2c80a944bc3fbbcbba0278e2bdaf8
https://doi.org/10.1158/0008-5472.22421333
https://doi.org/10.1158/0008-5472.22421333
Autor:
Gil Covarrubias, Yahan Zhang, Morgan E Lorkowski, Efstathios Karathanasis, Prabhani U. Atukorale, Taylor J. Moon, Wyatt M. Becicka, Peter Bielecki
Publikováno v:
Nanoscale Advances
The efficacy of immunotherapies is often limited by the immunosuppressive tumor microenvironment, which is populated with dysfunctional innate immune cells. To reprogram the tumor-resident innate immune cells, we developed immunostimulatory silica me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0067d39c4f683825a77fb0f0fcbe2173
http://europepmc.org/articles/PMC8386411
http://europepmc.org/articles/PMC8386411
Autor:
Ravi Bharadwaj, Christina F. Lusi, Siavash Mashayekh, Abhinit Nagar, Malireddi Subbarao, Griffin I. Kane, Kimberly Wodzanowski, Ashley Brown, Kendi Okuda, Amanda Monahan, Donggi Paik, Anubhab Nandy, Madison Anonick, William E. Goldman, Thirumala-Devi Kanneganti, Megan H. Orzalli, Catherine Leimkuhler Grimes, Prabhani U. Atukorale, Neal Silverman
SummaryCytosolic innate immune sensing is critical for protecting barrier tissues. NOD1 and NOD2 are cytosolic sensors of small peptidoglycan fragments (muropeptides) derived from the bacterial cell wall. These muropeptides enter cells, especially ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f06a72355307ae7569241110405574d
https://doi.org/10.1101/2022.09.29.509906
https://doi.org/10.1101/2022.09.29.509906
Autor:
Ravi Bharadwaj, Christina F. Lusi, Siavash Mashayekh, Abhinit Nagar, Malireddi Subbarao, Griffin I. Kane, Kimberly A. Wodzanowski, Ashley R. Brown, Kendi Okuda, Amanda Monahan, Donggi Paik, Anubhab Nandy, Madison V. Anonick, William E. Goldman, Thirumala-Devi Kanneganti, Megan H. Orzalli, Catherine Leimkuhler Grimes, Prabhani U. Atukorale, Neal Silverman
Publikováno v:
Immunity. 56:998-1012.e8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::293e5bd5b7c36e5fd95e636e94886435
https://doi.org/10.1016/j.immuni.2023.04.001
https://doi.org/10.1016/j.immuni.2023.04.001
Autor:
Prabhani U. Atukorale, Morgan E Lorkowski, Peter Bielecki, Efstathios Karathanasis, A.R. Santulli, Georgia Loutrianakis, Yahan Zhang, Kathleen Tong, Taylor Moon, Wyatt M. Becicka, Gil Covarrubias
Publikováno v:
J Control Release
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease, where even surgical resection and aggressive chemotherapy produce dismal outcomes. Immunotherapy is a promising alternative to conventional treatments, possessing the ability to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7e18e5df5f36357059434ad1989d82
https://doi.org/10.1016/j.jconrel.2020.11.014
https://doi.org/10.1016/j.jconrel.2020.11.014
Autor:
Gil Covarrubias, Taylor J. Moon, Shruthi Ravichandran, Efstathios Karathanasis, Prabhani U. Atukorale, Peter Bielecki, Michelle L. Wiese, Morgan E Lorkowski, Yahan Zhang, Wyatt M. Becicka
Publikováno v:
Nanoscale Horiz
The high mortality associated with glioblastoma multiforme (GBM) is attributed to its invasive nature, hypoxic core, resistant cell subpopulations and a highly immunosuppressive tumor microenvironment (TME). To support adaptive immune function and es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238583809ad92855af05a8e979d250e9
https://doi.org/10.1039/d0nh00446d
https://doi.org/10.1039/d0nh00446d
Autor:
Prabhani U. Atukorale, Taylor J. Moon, Alexandr R. Bokatch, Christina F. Lusi, Jackson T. Routhier, Victoria J. Deng, Efstathios Karathanasis
Publikováno v:
Nanoscale
Lethal cancer is characterized by drug-resistant relapse and metastasis. Here, we evaluate the efficacy of a neoadjuvant therapeutic strategy prior to surgery that combines the immune checkpoint inhibitor anti-PD1 with a powerful immunostimulatory na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e009dae35360a4f72d75c82b4129154
https://europepmc.org/articles/PMC8795493/
https://europepmc.org/articles/PMC8795493/
Autor:
Mayura P Umapathy, Gil Covarrubias, Morgan E Lorkowski, Taylor J. Moon, Prabhani U. Atukorale, Georgia Loutrianakis, Haley M. Sims, Michelle L. Wiese, Efstathios Karathanasis, Peter Bielecki
Publikováno v:
J Mater Chem B
To alter the immunosuppressive tumor microenvironment (TME), we developed an immunostimulatory nanoparticle (NP) to reprogram a tumor’s dysfunctional and inhibitory antigen-presenting cells (APCs) into properly activated APCs that stimulate tumor-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0b7261985c46e73d2c9810600885e7
https://europepmc.org/articles/PMC8732314/
https://europepmc.org/articles/PMC8732314/