Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Prabhakar R Gudla"'
Autor:
Debanjan Goswami, De Chen, Yue Yang, Prabhakar R Gudla, John Columbus, Karen Worthy, Megan Rigby, Madeline Wheeler, Suman Mukhopadhyay, Katie Powell, William Burgan, Vanessa Wall, Dominic Esposito, Dhirendra K Simanshu, Felice C Lightstone, Dwight V Nissley, Frank McCormick, Thomas Turbyville
Publikováno v:
eLife, Vol 9 (2020)
The RAS proteins are GTP-dependent switches that regulate signaling pathways and are frequently mutated in cancer. RAS proteins concentrate in the plasma membrane via lipid-tethers and hypervariable region side-chain interactions in distinct nano-dom
Externí odkaz:
https://doaj.org/article/c798200b000d4c1ab8ba16fab0ce9c68
Autor:
Mauricio Comas-Garcia, Siddhartha AK Datta, Laura Baker, Rajat Varma, Prabhakar R Gudla, Alan Rein
Publikováno v:
eLife, Vol 6 (2017)
Selective packaging of HIV-1 genomic RNA (gRNA) requires the presence of a cis-acting RNA element called the ‘packaging signal’ (Ψ). However, the mechanism by which Ψ promotes selective packaging of the gRNA is not well understood. We used fluo
Externí odkaz:
https://doaj.org/article/09617f0b4cb14182a2d740afa6b31500
Autor:
Gianluca Pegoraro, Daniel R. Larson, Carson C. Chow, George Zaki, Yihan Wan, Markus Hafner, Murali Palangat, Dimitrios G. Anastasakis, Joseph Rodriguez, Mayank Tandon, Prabhakar R. Gudla
Publikováno v:
Cell
The activities of RNA polymerase and the spliceosome are responsible for the heterogeneity in the abundance and isoform composition of mRNA in human cells. However, the dynamics of these megadalton enzymatic complexes working in concert on endogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca27462302fb9feb2979b051a0b928dd
https://europepmc.org/articles/PMC8183334/
https://europepmc.org/articles/PMC8183334/
Autor:
Prabhakar R. Gudla, David Sturgill, Yves Pommier, Eric G. Sun, Eri K. Hosogane, Robin Sebastian, Philipp Oberdoerffer, Mirit I. Aladjem, Sandra Burkett, William C. Reinhold, Andy D. Tran
Publikováno v:
Mol Cell
The inactive X chromosome (Xi) is inherently susceptible to genomic aberrations. Replication stress (RS) has been proposed as an underlying cause, but the mechanisms that protect from Xi instability remain unknown. Here, we show that macroH2A1.2, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a90358f4f691b25735f531b493d7ad8
https://europepmc.org/articles/PMC7483679/
https://europepmc.org/articles/PMC7483679/
Autor:
Sigal Shachar, Justin Kim, Laurent Ozbun, Tom Misteli, Iain D. C. Fraser, Luis M. Franco, Sun Jing, Manasi Gadkari, Prabhakar R. Gudla, Gianluca Pegoraro, Kyunghun Lee, George Zaki
Publikováno v:
Cytometry A
Deep learning is rapidly becoming the technique of choice for automated segmentation of nuclei in biological image analysis workflows. In order to evaluate the feasibility of training nuclear segmentation models on small, custom annotated image datas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1c458d26e2d57d24b64bdfa1534f04
https://pubmed.ncbi.nlm.nih.gov/33141508
https://pubmed.ncbi.nlm.nih.gov/33141508
Autor:
Karen M. Worthy, Dhirendra K. Simanshu, John Columbus, Madeline Wheeler, Suman Mukhopadhyay, Megan Rigby, Frank McCormick, De Chen, Dwight V. Nissley, Debanjan Goswami, Katie Powell, Dominic Esposito, Felice C. Lightstone, Thomas J. Turbyville, Vanessa Wall, Prabhakar R. Gudla, William E. Burgan, Yue Yang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67e216070fffcac00f5ca7e688668819
https://doi.org/10.7554/elife.47654.sa2
https://doi.org/10.7554/elife.47654.sa2
Autor:
Darawalee Wangsa, Prabhakar R. Gudla, Sigal Shachar, Tom Misteli, Ziad Mohamoud Jowhar, Thomas Ried, Gianluca Pegoraro, Jill L. Russ, Armin Raznahan
Publikováno v:
Methods. 142:30-38
The spatial organization of chromosomes in the nuclear space is an extensively studied field that relies on measurements of structural features and 3D positions of chromosomes with high precision and robustness. However, no tools are currently availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e3574a403c05342848348a426841ad
https://doi.org/10.1016/j.ymeth.2018.01.013
https://doi.org/10.1016/j.ymeth.2018.01.013
Autor:
Carson C. Chow, Prabhakar R. Gudla, Gianluca Pegoraro, Dimitrios G. Anastasakis, Yihan Wan, Daniel R. Larson, Mayank Tandon, George Zaki, Joseph Rodriguez, Markus Hafner, Murali Palangat
Publikováno v:
SSRN Electronic Journal.
The activities of RNA polymerase and the spliceosome are responsible for the heterogeneity in the abundance and isoform composition of mRNA in human cells. However, the dynamics of these megadalton enzymatic complexes working in concert on endogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a45a73231d2bf688fc6da7c67e600d47
https://doi.org/10.2139/ssrn.3467157
https://doi.org/10.2139/ssrn.3467157
Autor:
Vikas Soni, Grégory Fettweis, Thomas A. Johnson, Diego M. Presman, Prabhakar R. Gudla, Anh Huynh, Gianluca Pegoraro, David A. Garcia, George Zaki, Diana A. Stavreva, Geneva Williams, R. Louis Schiltz, Matthew L. Ferguson, Andrew McGowan, Gordon L. Hager, Murali Palangat, Arpita Upadhyaya
Publikováno v:
Mol Cell
Genes are transcribed in a discontinuous pattern referred to as RNA bursting, but the mechanisms regulating this process are unclear. Although many physiological signals, including glucocorticoid hormones, are pulsatile, the effects of transient stim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75f4fc8eb1851c53aab16b315cc830e
https://pubmed.ncbi.nlm.nih.gov/31421980
https://pubmed.ncbi.nlm.nih.gov/31421980
Autor:
Tom Misteli, Ziad Mohamoud Jowhar, Prabhakar R. Gudla, Thomas Ried, Erin Torres, Darawalee Wangsa, Gianluca Pegoraro, Armin Raznahan, Sigal Shachar, Jill L. Russ
Publikováno v:
Molecular Biology of the Cell
Sex chromosome aneuploidies (SCAs) are common genetic syndromes characterized by the presence of an aberrant number of X and Y chromosomes due to meiotic defects. These conditions impact structure and function of diverse tissues, but the proximal eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd8ae7f1188fffe4ca78d896d5db436