Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Prabhakar Kondaji Jadhav"'
Autor:
Kostas Gavardinas, John G. Luz, Nathan A. Calvert, Vaught Grant Matthews, Pablo Garcia Losada, Heather A Bullock, Ashraf Saeed, Donald P. Matthews, Yong Wang, Nita J. Patel, Venkatesh Krishnan, Judith W. Henck, Jonathan Edward Green, Sweetana Stephanie Ann, Prabhakar Kondaji Jadhav
Publikováno v:
Journal of Medicinal Chemistry. 59:750-755
A transdermal SARM has a potential to have therapeutic benefit through anabolic activity in muscle while sparing undesired effects of benign prostate hyperplasia (BPH) and liver-mediated decrease in HDL-C. 2-Chloro-4-[(2-hydroxy-2-methyl-cyclopentyl)
Autor:
Thierry Masquelin, Gary G. Deng, Prabhakar Kondaji Jadhav, Balagopalakrishna Chavali, David E. Timm, Najia Jin, Stephanie L. Stout, Mark J. Nilges, William F. Matter
Publikováno v:
Applied Magnetic Resonance
As an early visitor to the injured loci, neutrophil-derived human Myeloperoxidase (hMPO) offers an attractive protein target to modulate the inflammation of the host tissue through suitable inhibitors. We describe a novel methodology of using low tem
Autor:
Bruce W. Shaw, Yuke Zhang, Kenneth C. Cassidy, Robert M. Christie, Prabhakar Kondaji Jadhav, Jim D. Durbin, Gary G. Deng, Matthew Allen Schiffler, Kostas Gavardinas, Richard A. Brier, Keyun Qing, Donald P. Matthews, Michael A. Staszak, William F. Matter, Yong Wang, Kim Euibong Jemes, D. Scott Coffey
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1138-1142
Cathepsin S (Cat S) plays an important role in many pathological conditions, including abdominal aortic aneurysm (AAA). Inhibition of Cat S may provide a new treatment for AAA. To date, several classes of Cat S inhibitors have been reported, many of
Autor:
David Andrew Neel, Karen M. Zimmerman, Matthew L. Brown, Prabhakar Kondaji Jadhav, Robert Anthony Doti, Defauw Jean Marie, Stephon C. Smith, Peter Ambrose Lander, Sally Ann Kelley, Todd Fields, Timothy Alan Grese, Mitchell I. Steinberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2553-2557
Syntheses and SAR studies of 3,3-bisaryloxindole analogues provided potent mineralocorticoid receptor (MR) antagonists that were selective over other steroid nuclear hormone receptors.
Autor:
Matthew D. Belvo, Michael Gregory Bell, Douglas Linn Gernert, V. Scott Sharp, Joseph H. Kennedy, Hannah Yu, Peter Stanley Borromeo, Timothy Alan Grese, Sally Ann Kelley, Gregory A. Stephenson, Mitchell I. Steinberg, Prabhakar Kondaji Jadhav, Jeffrey D. Williams, Karen M. Zimmerman, Rachel N. Richey, Stanley P. Kolis, Peter Ambrose Lander
Publikováno v:
Journal of Medicinal Chemistry. 50:6443-6445
A novel, potent series of indole analogs were recently developed as MR antagonists, culminating in 14. This compound represents the first MR antagonist in this class of molecules, exhibiting picomolar binding affinity and in vivo blood pressure lower