Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Prabhakar K. Jadhav"'
Autor:
Xiaojun Wang, Xiaohong Yu, Kostas Gavardinas, Asim Dey, Hong Y Zhang, Gina Porter, Leah Porras, Lan Yu, Haihong Guo, Charles A Reidy, Joseph V Haas, Yanping Xu, Mark C Kowala, Prabhakar K Jadhav, John R Wetterau
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0292091 (2024)
Many of the pathological consequences of chronic kidney disease can be attributed to an elevation in serum phosphate levels. Current therapies focused on decreasing intestinal phosphate absorption to treat hyperphosphatemia are inadequate. The most e
Externí odkaz:
https://doaj.org/article/d4d6b1aa436147f6aee23698faf6982e
Autor:
Ruth R. Wexler, Robert M. Knabb, Jennifer X. Qiao, Karen A. Rossi, Prabhakar K. Jadhav, Xuhong Cheng, Dilip P. Modi, Joseph M. Luettgen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:29-35
Syntheses and SAR studies of 5-amidinobenzo[b]thiophene analogs provided compounds with low submicromolar factor IXa activity and equal or slightly better selectivity relative to factor Xa.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3028054f06269db92ec142d84f25724
https://doi.org/10.1016/j.bmcl.2004.10.045
https://doi.org/10.1016/j.bmcl.2004.10.045
Autor:
Joanne M. Smallheer, Carolyn A. Weigelt, Shaker A. Mousa, Wayne F. Daneker, Francis J. Woerner, Prabhakar K. Jadhav, Ruth R. Wexler, J S Wells
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:383-387
Analogues of isoxazoline alpha(v)beta(3) antagonist 1 designed to further restrict the four carbon alkyl tether were prepared by incorporating two spirocyclic scaffolds, 1-oxa-2-azaspiro[4,5]dec-2-ene and 1-oxa-2,7-diazaspiro[4,4]non-2-ene. Additiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9caac7ae7c146901831dac1355de79ff
https://doi.org/10.1016/j.bmcl.2003.10.057
https://doi.org/10.1016/j.bmcl.2003.10.057
Publikováno v:
Tetrahedron Letters. 42:3415-3418
General catalytic Cu(OAc)2/TEMPO in air or Cu(OAc)2/O2 systems for the CN and CO cross-coupling reactions with arylboronic acid have been discovered. N- and O-vinylation have also been demonstrated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9232818aa6072bf89035ff9d38c55a6b
https://doi.org/10.1016/s0040-4039(01)00510-x
https://doi.org/10.1016/s0040-4039(01)00510-x
Autor:
Karen L. Schlingmann, Adrienne L. Racanelli, Martha H. Corjay, Thomas M. Reilly, Sandra K. Gibbs, Prabhakar K. Jadhav
Publikováno v:
Journal of Cellular Biochemistry. 77:213-220
This study was performed to determine whether a highly selective nonpeptide alpha(v)beta(3) antagonist (SH306) would prove effective in inhibiting neointima formation in a rabbit cuff model. The animals were dosed with SH306, 5 mg/kg i.v., followed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4577e5260e74adf2e61a4f206e9c279c
https://doi.org/10.1002/(sici)1097-4644(20000501)77:2<213::aid-jcb5>3.0.co
https://doi.org/10.1002/(sici)1097-4644(20000501)77:2<213::aid-jcb5>3.0.co
Autor:
Patricia P Harlow, Susan M. Spitz, Mark S. Forsythe, Ruth R. Wexler, Martha H. Corjay, Joseph J. Petraitis, Peter J. Bouchard, Gregory C. Houghton, Shaker A. Mousa, Prabhakar K. Jadhav, Frank A. Barbera, Douglas G. Batt, Dilip P. Modi, Gary A. Cain
Publikováno v:
Journal of Medicinal Chemistry. 43:41-58
A new series of indazole-containing αvβ3 integrin antagonists is described. Starting with lead compound 18a, variations in a number of structural features were explored with respect to inhibition of the binding of β3-transfected 293 cells to fibri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cb1e0dfb66424a070cd1095d9734008
https://doi.org/10.1021/jm990049j
https://doi.org/10.1021/jm990049j
Autor:
Patricia P Harlow, Solomon Ka, Smallheer Jm, Martha H. Corjay, Ruth R. Wexler, Pitts William J, Prabhakar K. Jadhav, Shaker A. Mousa, Buynitsky Js, John Wityak, James W. Jetter, Tobin Ae
Publikováno v:
Journal of Medicinal Chemistry. 43:27-40
Starting with lead compound 2, we sought to increase the selectivity for αvβ3-mediated cell adhesion by examining the effects of structural changes in both the guanidine mimetic and the substituent α to the carboxylate. To prepare some of the desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c38fd1e699335d7b6c5067095a621cea
https://doi.org/10.1021/jm9900321
https://doi.org/10.1021/jm9900321
Autor:
Douglas Guy Batt, William F. DeGrado, Arlene Rockwell, Prabhakar K. Jadhav, Joseph J. Petraitis, Shaker A. Mousa, Maria Rafalski, William J. Pitts
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:937-942
Isoxazoline containing RGD mimetics were rapidly synthesized on a solid phase to optimize linkers, regioisomers of isoxazoline scaffolds, and exosite binding groups to yield lead alphavbeta3 antagonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c8d9bbebccb82d3d8d9fdb06eb23e3
https://doi.org/10.1016/s0960-894x(99)00114-6
https://doi.org/10.1016/s0960-894x(99)00114-6
Autor:
M.C. Schadt, Charles J. Eyermann, Patricia C. Weber, E. E. Huston, Hodge Carl Nicholas, F.A. Lewandowski, D. D. Mccabe, J. L. Duke, R. J. Deloskey, C.-H. Chang, Prabhakar K. Jadhav, Patrick Y.S. Lam, Paul J. Ala
Publikováno v:
Journal of Biological Chemistry. 273:12325-12331
As long as the threat of human immunodeficiency virus (HIV) protease drug resistance still exists, there will be a need for more potent antiretroviral agents. We have therefore determined the crystal structures of HIV-1 protease in complex with six c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689417b6939bbd16e9df99fb6043cc24
https://doi.org/10.1074/jbc.273.20.12325
https://doi.org/10.1074/jbc.273.20.12325
Autor:
George V. De Lucca, Wayne F. Daneker, Paul E. Aldrich, Y. Ru, C.-H. Chang, Charles J. Eyermann, C.Nicholas Hodge, Edward R. Holler, Francis J. Woerner, and Joseph C. Calabrese, Robert F. Kaltenbach, Fernandez Ch, Prabhakar K. Jadhav, Patrick Y.S. Lam, George Emmett
Publikováno v:
Journal of the American Chemical Society. 120:4570-4581
One important factor influencing the affinity of a flexible ligand for a receptor is the internal strain energy required to attain the bound conformation. Calculation of fully equilibrated ensembles of bound and free ligand and receptor conformations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f445c4e3755bdb4b9da6a68a7cfc8435
https://doi.org/10.1021/ja972357h
https://doi.org/10.1021/ja972357h