Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Prabha Shrestha"'
Autor:
Hannah K. Jaeger, David A. Davis, Ashwin Nair, Prabha Shrestha, Alexandra Stream, Amulya Yaparla, Robert Yarchoan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Epstein-Barr virus (EBV) downregulates immune surface markers to avoid immune recognition. Pomalidomide (Pom) was previously shown to increase immune surface marker expression in EBV-infected tumor cells. We explored the mechanism by which P
Externí odkaz:
https://doaj.org/article/771ce4b7f791411a9936e4e4d4d179d5
Autor:
Prabha Shrestha, Yana Astter, David A. Davis, Ting Zhou, Constance M. Yuan, Ramya Ramaswami, Hao-Wei Wang, Kathryn Lurain, Robert Yarchoan
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTPrimary effusion lymphoma (PEL), an aggressive non-Hodgkin lymphoma caused by Kaposi sarcoma-associated herpesvirus (KSHV), lacks standard therapy and has a median survival of 10–22 months with combination chemotherapy. PEL is a tumor of pl
Externí odkaz:
https://doaj.org/article/180683e63907413383b719de45e83eee
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background The two oncogenic human gammaherpesviruses, Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein–Barr virus (EBV), both downregulate immune surface molecules, such as MHC-I, ICAM-1, and B7-2, enabling them to evade T-cell an
Externí odkaz:
https://doaj.org/article/4e55c8f4ccaa4aa0a3e91185f4226ba2
Autor:
Robin Man Karmacharya, Satish Vaidya, Amit Kumar Singh, Prasesh Dhakal, Sushil Dahal, Niroj Bhandari, Sohail Bade, Sahil Bade, Prabha Shrestha
Publikováno v:
Indian Journal of Vascular and Endovascular Surgery, Vol 8, Iss 6, Pp 153-156 (2021)
Radiofrequency ablation (RFA) is one of the recent yet adequately studied minimal invasive surgery for varicose veins. The aim of this manuscript is to share our technique of RFA for varicose veins. The technique has been revised over time and has be
Externí odkaz:
https://doaj.org/article/cca96215561645efb4176620fc634338
Autor:
Sushil Dahal, Robin Man Karmacharya, Amit Kumar Singh, Satish Vaidya, Prasesh Dhakal, Pratima Thapa, Prabha Shrestha, Niroj Bhandari, Sohail Bade, Sahil Bade
Publikováno v:
Journal of Nepal Medical Association, Vol 60, Iss 245 (2022)
Introduction: Peripheral vascular trauma can result in limb or life-threatening injuries. Early surgical intervention leads to a better outcome. Diagnosis is made clinically, by non-invasive and invasive imaging modalities. Our aim in this study is t
Externí odkaz:
https://doaj.org/article/0a52f4e297834eef9043584f274ca5a2
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 2054 (2022)
Most viruses encode their own proteases to carry out viral maturation and these often require dimerization for activity. Studies on human immunodeficiency virus type 1 (HIV-1), type 2 (HIV-2) and human T-cell leukemia virus (HTLV-1) proteases have sh
Externí odkaz:
https://doaj.org/article/64eace07f88d46359bcf52dd5483a592
Autor:
David A. Davis, Haydar Bulut, Prabha Shrestha, Amulya Yaparla, Hannah K. Jaeger, Shin-ichiro Hattori, Paul T. Wingfield, John J. Mieyal, Hiroaki Mitsuya, Robert Yarchoan
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for coronavirus disease 2019 (COVID-19), encodes two proteases required for replication. The main protease (Mpro), encoded as part of two polyproteins, pp1a an
Externí odkaz:
https://doaj.org/article/125d60db37064da6acb66a5868cdb04c
Autor:
Prasesh Dhakal, Pratima Thapa, Sushil Dahal, Niroj Bhandari, Sohail Bade, Prabha Shrestha, Robin Man Karmacharya, Amit Kumar Singh, Satish Vaidya
Publikováno v:
Indian Journal of Vascular and Endovascular Surgery, Vol 7, Iss 4, Pp 441-443 (2020)
Trauma is an uncommon cause of common femoral artery aneurysm (CFAA). We present a 31-year-old male with a history of intravenous drug abuse with an incidental finding of the right leg CFA aneurysm during ultrasonography Doppler for deep vein thrombo
Externí odkaz:
https://doaj.org/article/e7a4381176a74aa995f73f12539db4f4
Autor:
Prabha Shrestha, David A Davis, Hannah K Jaeger, Alexandra Stream, Ashley I Aisabor, Robert Yarchoan
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009091 (2021)
Pomalidomide (Pom) is an immunomodulatory drug that has efficacy against Kaposi's sarcoma, a tumor caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Pom also induces direct cytotoxicity in primary effusion lymphoma (PEL), a B-cell malignancy
Externí odkaz:
https://doaj.org/article/b3d30c82e82642ab96622ea46ba2b8f4
Autor:
Robin Man Karmacharya, Satish Vaidya, Amit Kumar Singh, Sushil Dahal, Prasesh Dhakal, Niroj Bhandari, Sohail Bade, Prabha Shrestha, Pratima Thapa
Publikováno v:
Journal of Nepal Medical Association, Vol 58, Iss 225 (2020)
Introduction: Arteriovenous fistulas are a preferred choice for hemodialysis access in chronic kidney disease patients. There is increased adoption of arteriovenous fistula creation in Nepal. Our objective is to study various arteriovenous fistulas t
Externí odkaz:
https://doaj.org/article/f557d7ad05134161a9c7dd8563e0da39