Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Prabesh Bhattarai"'
Autor:
Özkan İş, Xue Wang, Joseph S. Reddy, Yuhao Min, Elanur Yilmaz, Prabesh Bhattarai, Tulsi Patel, Jeremiah Bergman, Zachary Quicksall, Michael G. Heckman, Frederick Q. Tutor-New, Birsen Can Demirdogen, Launia White, Shunsuke Koga, Vincent Krause, Yasuteru Inoue, Takahisa Kanekiyo, Mehmet Ilyas Cosacak, Nastasia Nelson, Annie J. Lee, Badri Vardarajan, Richard Mayeux, Naomi Kouri, Kaancan Deniz, Troy Carnwath, Stephanie R. Oatman, Laura J. Lewis-Tuffin, Thuy Nguyen, for the Alzheimer’s Disease Neuroimaging Initiative, Minerva M. Carrasquillo, Jonathan Graff-Radford, Ronald C. Petersen, Clifford R. Jr Jack, Kejal Kantarci, Melissa E. Murray, Kwangsik Nho, Andrew J. Saykin, Dennis W. Dickson, Caghan Kizil, Mariet Allen, Nilüfer Ertekin-Taner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract To uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer’s disease, we performed single nucleus RNA sequencing in 24 Alzheimer’s disease and control brains and focused on vascular and astrocyte clusters as mai
Externí odkaz:
https://doaj.org/article/0f4d86fabcd9496f8761615d7234bc5b
Autor:
Tohid Siddiqui, Mehmet Ilyas Cosacak, Stanislava Popova, Prabesh Bhattarai, Elanur Yilmaz, Annie J. Lee, Yuhao Min, Xue Wang, Mariet Allen, Özkan İş, Zeynep Tansu Atasavum, Natalia Rodriguez-Muela, Badri N. Vardarajan, Delaney Flaherty, Andrew F. Teich, Ismael Santa-Maria, Uwe Freudenberg, Carsten Werner, Giuseppe Tosto, Richard Mayeux, Nilüfer Ertekin-Taner, Caghan Kizil
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract Neurogenesis, crucial for brain resilience, is reduced in Alzheimer’s disease (AD) that induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring neurogenesis could counteract neurodegenerative pathology.
Externí odkaz:
https://doaj.org/article/bebfc2431c024aae887659ececd580cc
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 5, Pp 824-827 (2020)
Alzheimer’s disease cannot be cured as of yet. Our current understanding on the causes of Alzheimer’s disease is limited. To develop treatments, experimental models that represent a particular cellular phase of the disease and more rigorous scrut
Externí odkaz:
https://doaj.org/article/b7c74614ba22423e84de9a80a7e92004
Autor:
Lydia Reinhardt, Susanne Kordes, Peter Reinhardt, Michael Glatza, Matthias Baumann, Hannes C.A. Drexler, Sascha Menninger, Gunther Zischinsky, Jan Eickhoff, Claudia Fröb, Prabesh Bhattarai, Guruchandar Arulmozhivarman, Lara Marrone, Antje Janosch, Kenjiro Adachi, Martin Stehling, Eric N. Anderson, Masin Abo-Rady, Marc Bickle, Udai Bhan Pandey, Michell M. Reimer, Caghan Kizil, Hans R. Schöler, Peter Nussbaumer, Bert Klebl, Jared L. Sterneckert
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 502-517 (2019)
Summary: Neuroinflammation is a hallmark of neurological disorders and is accompanied by the production of neurotoxic agents such as nitric oxide. We used stem cell-based phenotypic screening and identified small molecules that directly protected neu
Externí odkaz:
https://doaj.org/article/d6324808720f45358bb83abf2c104f0a
Autor:
Mehmet Ilyas Cosacak, Prabesh Bhattarai, Philip L. De Jager, Vilas Menon, Giuseppe Tosto, Caghan Kizil
Publikováno v:
Cells, Vol 11, Iss 11, p 1807 (2022)
Neurogenesis is significantly reduced in Alzheimer’s disease (AD) and is a potential therapeutic target. Contrary to humans, a zebrafish can regenerate its diseased brain, and thus is ideal for studying neurogenesis. To compare the AD-related molec
Externí odkaz:
https://doaj.org/article/79850aaec113457b87589be95d66c8c6
Publikováno v:
STAR Protocols, Vol 1, Iss 1, Pp 100042- (2020)
SUMMARY: Single-cell sequencing (sc-Seq) is a powerful tool to investigate the molecular signatures of cell types in a complex mixture of cells. A critical step in sc-Seq is preparing a single-cell suspension with a high number of viable cells. Here,
Externí odkaz:
https://doaj.org/article/aaa22db56ee8420db73c40fc1da97a74
Autor:
Violeta Mashkaryan, Tohid Siddiqui, Stanislava Popova, Mehmet Ilyas Cosacak, Prabesh Bhattarai, Kerstin Brandt, Nambirajan Govindarajan, Andreas Petzold, Susanne Reinhardt, Andreas Dahl, Roger Lefort, Caghan Kizil
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Recent findings suggest that reduced neurogenesis could be one of the underlying reasons for the exacerbated neuropathology in humans, thus restoring the neural stem cell proliferation and neurogenesis could help to circumvent some pathological aspec
Externí odkaz:
https://doaj.org/article/78798b81b4874c009527fcc03c5d3adc
Autor:
Prabesh Bhattarai, Mehmet Ilyas Cosacak, Violeta Mashkaryan, Sevgican Demir, Stanislava Dimitrova Popova, Nambirajan Govindarajan, Kerstin Brandt, Yixin Zhang, Weipang Chang, Konstantinos Ampatzis, Caghan Kizil
Publikováno v:
PLoS Biology, Vol 18, Iss 1, p e3000585 (2020)
It was recently suggested that supplying the brain with new neurons could counteract Alzheimer's disease (AD). This provocative idea requires further testing in experimental models in which the molecular basis of disease-induced neuronal regeneration
Externí odkaz:
https://doaj.org/article/8d5216d5f4864241a8d4ccbdf3cf52d2
Autor:
Tohid Siddiqui, Prabesh Bhattarai, Stanislava Popova, Mehmet Ilyas Cosacak, Sanjeev Sariya, Yixin Zhang, Richard Mayeux, Giuseppe Tosto, Caghan Kizil
Publikováno v:
Cells, Vol 10, Iss 10, p 2748 (2021)
Neurogenesis decreases in Alzheimer’s disease (AD) patients, suggesting that restoring the normal neurogenic response could be a disease modifying intervention. To study the mechanisms of pathology-induced neuro-regeneration in vertebrate brains, z
Externí odkaz:
https://doaj.org/article/0f577cd1263a49538ea97d57cc823b42
Autor:
Hilal Celikkaya, Mehmet Ilyas Cosacak, Christos Papadimitriou, Stanislava Popova, Prabesh Bhattarai, Srijeeta Nag Biswas, Tohid Siddiqui, Sabrina Wistorf, Isabel Nevado-Alcalde, Lisa Naumann, Violeta Mashkaryan, Kerstin Brandt, Uwe Freudenberg, Carsten Werner, Caghan Kizil
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Astrocytes are abundant cell types in the vertebrate central nervous system and can act as neural stem cells in specialized niches where they constitutively generate new neurons. Outside the stem cell niches, however, these glial cells are not neurog
Externí odkaz:
https://doaj.org/article/02433395efe04380954fd4a1a09f9d64