Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Prabagaran Narayanasamy"'
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 8, Pp 9149-9161 (2024)
Metals play vital roles in biological systems, with iron/heme being essential for cellular and metabolic functions necessary for survival and/or virulence in many bacterial pathogens. Given the rise of bacterial resistance to current antibiotics, the
Externí odkaz:
https://doaj.org/article/e8aded63cce24392b078b6768ea42920
Publikováno v:
Microorganisms, Vol 12, Iss 1, p 18 (2023)
In a recent effort to mitigate harm from human pathogens, many biosynthetic pathways have been extensively evaluated for their ability to inhibit pathogen growth and to determine drug targets. One of the important products/targets of such pathways is
Externí odkaz:
https://doaj.org/article/dd13e9c9b79d4da7a36a4d7889d51087
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/3f0eaf919c234b1ba3fd2532bebaa57d
Publikováno v:
ACS Infectious Diseases. 9:716-738
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92135539417c896391672860323c4fb4
https://doi.org/10.1021/acsinfecdis.3c00050
https://doi.org/10.1021/acsinfecdis.3c00050
Publikováno v:
Redox Biology, Vol 14, Iss , Pp 465-473 (2018)
The glyoxalase pathway functions to detoxify reactive dicarbonyl compounds, most importantly methylglyoxal. The glyoxalase pathway is an antioxidant defense mechanism that is essential for neuroprotection. Excessive concentrations of methylglyoxal ha
Externí odkaz:
https://doaj.org/article/28ac17470100492aabf1b2628f4fa85c
Autor:
Joel Frandsen, Prabagaran Narayanasamy
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Oxidative stress is damaging to cells and contributes to aging and neurodegenerative disease. This state is mediated by production of imbalanced molecules, and reactive dicarbonyl compounds - mainly methylglyoxal. The glyoxalase pathway is a
Externí odkaz:
https://doaj.org/article/1d301b8c313646898b9c429cb8f14023
Autor:
Zachary W. Scott, Seoung-ryoung Choi, Geoffrey A. Talmon, Bradley E. Britigan, Prabagaran Narayanasamy
Publikováno v:
ACS Infectious Diseases. 8:2096-2105
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eebcb18f4061ae82fd1817b17a7eef1
https://doi.org/10.1021/acsinfecdis.2c00196
https://doi.org/10.1021/acsinfecdis.2c00196
Publikováno v:
mSphere, Vol 4, Iss 4 (2019)
ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a global threat. The course of TB is negatively impacted by coexistent infection with human immunodeficiency virus type 1 (HIV). Macrophage infection with these pathogens modul
Externí odkaz:
https://doaj.org/article/0ec1f10b4c5244c699ae66c75232b0cb
Autor:
Joel Frandsen, Prabagaran Narayanasamy
Publikováno v:
ACS Chemical Neuroscience. 13:1165-1177
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fdd4ae7d055b780580245871b137fd6
https://doi.org/10.1021/acschemneuro.1c00667
https://doi.org/10.1021/acschemneuro.1c00667
Publikováno v:
ACS Infectious Diseases. 7:2299-2309
The emergence of drug-resistant pathogens causes the greatest challenge for drug development research. Recently, gallium(III)-based compounds have received great attention as novel antimicrobial agents against drug-resistant pathogens. Here, we synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03b0683735b0897056a9a8e17e9fb26f
https://doi.org/10.1021/acsinfecdis.0c00896
https://doi.org/10.1021/acsinfecdis.0c00896