Doxycycline rescues recognition memory and circadian motor rhythmicity but does not prevent terminal disease in fatal familial insomnia mice

Autor: Mara Rigamonti, Roberto Chiesa, Ihssane Bouybayoune, Elena Restelli, Ilaria Bertani, Luca Porcu, Stefano Zordan, Antonio Masone, Giada Lavigna, Jacopo Lucchetti, Luca Imeri, Marco Gobbi

Publikováno v: Neurobiology of Disease, Vol 158, Iss, Pp 105455-(2021)
Neurobiology of Disease

Fatal familial insomnia (FFI) is a dominantly inherited prion disease linked to the D178N mutation in the gene encoding the prion protein (PrP). Symptoms, including insomnia, memory loss and motor abnormalities, appear around 50 years of age, leading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947f6abf69c24f0e3ded57cf103446a5
http://www.sciencedirect.com/science/article/pii/S0969996121002047

Doppel and PrPC co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cells

Autor: Chiara Zurzolo, Maddalena Costanzo, Alessandro Negro, Vincenza Campana, Daniela Sarnataro, M. Catia Sorgato, Anna Caputo

Publikováno v: Biochemical Journal
Biochemical Journal, 2010, 425 (2), pp.341-51. ⟨10.1042/BJ20091050⟩
Biochemical Journal, Portland Press, 2010, 425 (2), pp.341-51. ⟨10.1042/BJ20091050⟩

International audience; Dpl (doppel) is a paralogue of the PrPC (cellular prion protein), whose misfolded conformer (the scrapie prion protein, PrPSc) is responsible for the onset of TSEs (transmissible spongiform encephalopathies) or prion diseases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b535cf11e1441f046e7235fd030d365
https://doi.org/10.1042/bj20091050

A Retrospective Cohort Study of a Newly Proposed Criteria for Sporadic Creutzfeldt–Jakob Disease.

Autor: Nonaka, Toshiaki¹ (AUTHOR), Ae, Ryusuke^2,3 (AUTHOR), Kosami, Koki^2,3 (AUTHOR), Tange, Hiroya¹ (AUTHOR), Kaneko, Miho¹ (AUTHOR), Nakagaki, Takehiro¹ (AUTHOR), Hamaguchi, Tsuyoshi^2,4 (AUTHOR), Sanjo, Nobuo^2,5,6 (AUTHOR), Nakamura, Yoshikazu^2,3 (AUTHOR), Kitamoto, Tetsuyuki^2,7 (AUTHOR), Kuroiwa, Yoshiyuki^2,8 (AUTHOR), Kasuga, Kensaku^2,9 (AUTHOR), Doyu, Manabu^2,10 (AUTHOR), Tanaka, Fumiaki^2,11 (AUTHOR), Abe, Koji^2,12,13 (AUTHOR), Murayama, Shigeo^2,14,15 (AUTHOR), Yabe, Ichiro^2,16 (AUTHOR), Mochizuki, Hideki^2,17 (AUTHOR), Matsushita, Takuya^2,18 (AUTHOR), Murai, Hiroyuki^2,19 (AUTHOR)

Publikováno v: Diagnostics (2075-4418). Nov2024, Vol. 14 Issue 21, p2424. 14p.

Genetic Variants Associated with the Age of Onset Identified by Whole-Exome Sequencing in Fatal Familial Insomnia.

Autor: Thüne, Katrin^1,2 (AUTHOR) k.thuene@googlemail.com, Schmitz, Matthias^1,2 (AUTHOR) matthias.schmitz@med.uni-goettingen.de, Wiedenhöft, John³ (AUTHOR) john.wiedenhoeft@med.uni-goettingen.de, Shomroni, Orr⁴ (AUTHOR) orr.shomroni@med.uni-goettingen.de, Göbel, Stefan¹ (AUTHOR) timothy.bunck@med.uni-goettingen.de, Bunck, Timothy¹ (AUTHOR) neelam.younas@med.uni-goettingen.de, Younas, Neelam¹ (AUTHOR) saima.zafar@med.uni-goettingen.de, Zafar, Saima¹ (AUTHOR) peter.hermann@med.uni-goettingen.de, Hermann, Peter¹ (AUTHOR) ingazerr@med.uni-goettingen.de, Zerr, Inga^1,2 (AUTHOR)

Publikováno v: Cells (2073-4409). Aug2023, Vol. 12 Issue 16, p2053. 11p.

Molecular Mechanisms Associated with Neurodegeneration of Neurotropic Viral Infection.

Autor: Wongchitrat, Prapimpun, Chanmee, Theerawut, Govitrapong, Piyarat

Publikováno v: Molecular Neurobiology; May2024, Vol. 61 Issue 5, p2881-2903, 23p