Zobrazeno 1 - 10
of 29
pro vyhledávání: '"PrP, prion protein"'
Autor:
Mara Rigamonti, Roberto Chiesa, Ihssane Bouybayoune, Elena Restelli, Ilaria Bertani, Luca Porcu, Stefano Zordan, Antonio Masone, Giada Lavigna, Jacopo Lucchetti, Luca Imeri, Marco Gobbi
Publikováno v:
Neurobiology of Disease, Vol 158, Iss, Pp 105455-(2021)
Neurobiology of Disease
Neurobiology of Disease
Fatal familial insomnia (FFI) is a dominantly inherited prion disease linked to the D178N mutation in the gene encoding the prion protein (PrP). Symptoms, including insomnia, memory loss and motor abnormalities, appear around 50 years of age, leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947f6abf69c24f0e3ded57cf103446a5
http://www.sciencedirect.com/science/article/pii/S0969996121002047
http://www.sciencedirect.com/science/article/pii/S0969996121002047
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (2), pp.100878. ⟨10.1016/j.jbc.2021.100878⟩
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (2), pp.100878. ⟨10.1016/j.jbc.2021.100878⟩
International audience; Prions are transmissible protein pathogens most reliably detected by a bioassay in a suitable host, typically mice. However, the mouse bioassay is slow and cumbersome, and relatively insensitive to low titers of prion infectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07e7894706e3ed17baa099100710dce
https://www.repository.cam.ac.uk/handle/1810/323904
https://www.repository.cam.ac.uk/handle/1810/323904
Autor:
Janine Kamps, Konstanze F. Winklhofer, Roland Winter, Yu-Hsuan Lin, Jörg Tatzelt, Rosario Oliva, Verian Bader
Publikováno v:
The Journal of Biological Chemistry
Formation of biomolecular condensates through liquid-liquid phase separation (LLPS) has been described for several pathogenic proteins linked to neurodegenerative diseases and is discussed as an early step in the formation of protein aggregates with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2991f2f914d33e0afc0ae93c3ca3f40
http://europepmc.org/articles/PMC8254114
http://europepmc.org/articles/PMC8254114
Autor:
Gerold Schmitt-Ulms, Mohadeseh Mehrabian, Hamza Arshad, Joel C. Watts, Zaid A.M. Al-Azzawi, Matthew E. C. Bourkas, Zeel Patel
Publikováno v:
The Journal of Biological Chemistry
The study of prions and the discovery of candidate therapeutics for prion disease have been facilitated by the ability of prions to replicate in cultured cells. Paradigms in which prion proteins from different species are expressed in cells with low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c611fbe68ad93669b9774e2ea00b43d4
https://pubmed.ncbi.nlm.nih.gov/34390689
https://pubmed.ncbi.nlm.nih.gov/34390689
Autor:
Sabrina Cronier, Anthony R. Clarke, John Collinge, Graham S. Jackson, Jonathan D. F. Wadsworth, M. Howard Tattum, Nathalie Gros
Publikováno v:
UK Funders’ TSE Workshop
UK Funders’ TSE Workshop, Labo/service de l'auteur, Ville service., Oct 1999, Warwick, United Kingdom. pp.Inconnu
Biochemical Journal
UK Funders’ TSE Workshop, Labo/service de l'auteur, Ville service., Oct 1999, Warwick, United Kingdom. pp.Inconnu
Biochemical Journal
Disease-related PrP(Sc) [pathogenic PrP (prion protein)] is classically distinguished from its normal cellular precursor, PrP(C)(cellular PrP) by its detergent insolubility and partial resistance to proteolysis. Although molecular diagnosis of prion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4111cf3755a12dc833b8d1db20cb7ed5
https://hal.inrae.fr/hal-02812714
https://hal.inrae.fr/hal-02812714
Autor:
Yi-Hsuan Pan, Chonggang Yuan, Jiyan Ma, Xiangyi Zhang, Guohua Yu, Ji Ma, Chenhua Pan, Ying Chen
Publikováno v:
The Journal of Biological Chemistry
Conversion of normal prion protein (PrPC) to the pathogenic PrPSc conformer is central to prion diseases such as Creutzfeldt–Jakob disease and scrapie; however, the detailed mechanism of this conversion remains obscure. To investigate how the N-ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4462fccaafb86567b861dcb8b340532b
https://doi.org/10.1016/j.jbc.2021.101344
https://doi.org/10.1016/j.jbc.2021.101344
Autor:
Elena Quaglio, Vanessa Capone, Vladimiro Artuso, Fabio Fiordaliso, Ignazio Roiter, Davide Ortolan, Michele Sallese, Alessandro Corbelli, Galina V. Beznoussenko, Elena Restelli, Manuela Pozzoli, Roberto Chiesa
Publikováno v:
The Journal of Biological Chemistry
Fatal familial insomnia (FFI), genetic Creutzfeldt–Jakob disease (gCJD), and Gerstmann–Sträussler–Scheinker (GSS) syndrome are neurodegenerative disorders linked to prion protein (PrP) mutations. The pathogenic mechanisms are not known, but in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3782460cda7c20d4fd5164939fecf2
https://doi.org/10.1016/j.jbc.2021.100490
https://doi.org/10.1016/j.jbc.2021.100490
Autor:
Taichi Hamanaka, Hiroshi Kurahashi, Katsumi Doh-ura, Ayumi Oguma, Keiko Nishizawa, Kenta Teruya, Yuji Sakasegawa
Publikováno v:
Biochemistry and Biophysics Reports
No remedies for prion disease have been established, and the conversion of normal to abnormal prion protein, a key event in prion disease, is still unclear. Here we found that substances in beetle grub hemolymph, after they were browned by aging for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dfc841bd8f620bc01d8a2d1b4b8535
https://doi.org/10.1016/j.bbrep.2015.07.009
https://doi.org/10.1016/j.bbrep.2015.07.009
Autor:
Milica Vucetic, Kari E. Fladmark, Antonio Cuadrado, Irina Milisav, Bilge Debelec, Marta Pajares, Samo Ribarič, Irundika H.K. Dias, Huveyda Basaga, Natalia Jiménez-Moreno
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Redox Biology
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Redox Biology
Biblos-e Archivo. Repositorio Institucional de la UAM
WOS: 000367338700040
PubMed ID: 26381917
Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protei
PubMed ID: 26381917
Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704cabd6dd52ab864fe6016a11573eb5
https://publications.aston.ac.uk/id/eprint/26853/1/Redox_control_of_protein_degradation.pdf
https://publications.aston.ac.uk/id/eprint/26853/1/Redox_control_of_protein_degradation.pdf
Autor:
Anita, Alvarez-Laviada, Ivan, Kadurin, Assunta, Senatore, Roberto, Chiesa, Annette C, Dolphin
Publikováno v:
Biochemical Journal
It has been shown recently that PrP (prion protein) and the calcium channel auxiliary α2δ subunits interact in neurons and expression systems [Senatore, Colleoni, Verderio, Restelli, Morini, Condliffe, Bertani, Mantovani, Canovi, Micotti, Forloni,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe40890fd1a39cd1972967732b318d70
https://pubmed.ncbi.nlm.nih.gov/24329154
https://pubmed.ncbi.nlm.nih.gov/24329154