Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Prüstel, Thorsten"'
T cell receptor signaling must operate reliably under tight time constraints. While assuming quite different mechanisms, two prominent models of T cell receptor activation, kinetic segregation and kinetic proofreading, both introduce a distinct time
Externí odkaz:
http://arxiv.org/abs/2412.06773
Biological cells can exchange messages through soluble molecules or membrane-bound receptors. In particular in the latter case, the interaction is usually located in specific regions of the interacting cells and may depend on or induce local morpholo
Externí odkaz:
http://arxiv.org/abs/2312.05703
Cells exhibit a wide variety of different shapes. This diversity poses a challenge for computational approaches that attempt to shed light on the role cell geometry plays in regulating cell physiology and behavior. The simulation platform Simmune is
Externí odkaz:
http://arxiv.org/abs/2003.13634
The path decomposition expansion represents the propagator of the irreversible reaction as a convolution of the first-passage, last-passage and rebinding time probability densities. Using path integral technique, we give an elementary, yet rigorous,
Externí odkaz:
http://arxiv.org/abs/1604.04903
We present a simulation algorithm that accurately propagates a molecule pair using large time steps without the need to invoke the full exact analytical solutions of the Smoluchowski diffusion equation. Because the proposed method only uses uniform a
Externí odkaz:
http://arxiv.org/abs/1509.06810
Building on mathematical similarities between quantum mechanics and theories of diffusion-influenced reactions, we discuss how the propagator of a reacting molecule pair can be represented as a product of three factors in the Laplace domain. This rep
Externí odkaz:
http://arxiv.org/abs/1508.01595
Rapid rebinding of molecular interaction partners that are in close proximity after dissociation leads to a dissociation and association kinetics that can profoundly differ from predictions based on bulk reaction models. The cause of this effect can
Externí odkaz:
http://arxiv.org/abs/1504.07700
We further develop the general theory of the area reactivity model that provides an alternative description of the diffusion-influenced reaction of an isolated receptor-ligand pair in terms of a generalized Feynman-Kac equation. We analyze both the i
Externí odkaz:
http://arxiv.org/abs/1405.3021
We investigate the reversible diffusion-influenced reaction of an isolated pair in two space dimensions in the context of the area reactivity model. We compute the exact Green's function in the Laplace domain for the initially unbound molecule. Furth
Externí odkaz:
http://arxiv.org/abs/1311.2125