Novel insights in the pathomechanism of Brugada syndrome and fever-related type 1 ECG changes in a preclinical study using human-induced pluripotent stem cell-derived cardiomyocytes.

Autor: Li Y; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim and Göttingen, Mannheim, Germany., Dinkel H; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim and Göttingen, Mannheim, Germany., Pakalniskyte D; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim and Göttingen, Mannheim, Germany., Busley AV; DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim and Göttingen, Mannheim, Germany.; Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany., Cyganek L; DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim and Göttingen, Mannheim, Germany.; Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany., Zhong R; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany., Zhang F; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany., Xu Q; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany.; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China., Maywald L; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim and Göttingen, Mannheim, Germany., Aweimer A; Department of Cardiology and Angiology, Bergmannsheil University Hospitals, Ruhr University of Bochum, Bochum, Germany., Huang M; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany., Liao Z; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany., Meng Z; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany., Yan C; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany., Prädel T; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim and Göttingen, Mannheim, Germany., Rose L; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany., Moscu-Gregor A; Center for Human Genetics and Laboratory Medicine, Martinsried, Germany., Hohn A; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany., Yang Z; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany., Qiao L; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany., Mügge A; Department of Cardiology and Angiology, Bergmannsheil University Hospitals, Ruhr University of Bochum, Bochum, Germany., Zhou X; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim and Göttingen, Mannheim, Germany.; Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, China., Akin I; First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), Heidelberg University, Mannheim, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim and Göttingen, Mannheim, Germany., El-Battrawy I; Department of Cardiology and Angiology, Bergmannsheil University Hospitals, Ruhr University of Bochum, Bochum, Germany.

Publikováno v: Clinical and translational medicine [Clin Transl Med] 2023 Mar; Vol. 13 (3), pp. e1130.