Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists

Autor: Iain Kilty, Dave Singh, Eilise M. Ryan, Ppeter J. Barnes, Gussie Beech, Richard D. Emes, Irina Tcherniaeva, Louise E. Donnelly, Sarah R. Walmsley, Moira K. B. Whyte, Jadwiga A. Wedzicha, Martin A. Bewley, Umme Kolsum, Joby Cole, Jennifer L. Marshall, William L. Rumsey, Richard C. Budd, Yolanda Sanchez, Christopher E. Brightling, Gavin C. Donaldson, Gguy A.M. Berbers, David H. Dockrell, Paul Collini

Publikováno v: Bewley, M A, Budd, R C, Ryan, E, Cole, J, Collini, P, Marshall, J, Kolsum, U, Beech, G, Emes, R D, Tcherniaeva, I, Berbers, G A M, Walmsley, S R, Donaldson, G, Wedzicha, J A, Kilty, I, Rumsey, W, Sanchez, Y, Brightling, C E, Donnelly, L E, Barnes, P J, Singh, D & Whyte, M K B & Dockrell, D H 2018, ' Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists ', American Journal of Respiratory and Critical Care Medicine, vol. 198, no. 6, pp. 739-750 . https://doi.org/10.1164/rccm.201705-0903OC
Bewley, M A, Budd, R C, Ryan, E, Cole, J, Collini, P, Marshall, J, Kolsum, U, Beech, G, Emes, R D, Tcherniaeva, I, Berbers, G A M, Walmsley, S R, Donaldson, G, Wedzicha, J A, Kilty, I, Rumsey, W, Sanchez, Y, Brightling, C, Donnelly, L E, Barnes, P J, Singh, D, Whyte, M K B & Dockrell, D H 2018, ' Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.201705-0903OC

Rationale: Previous studies have identified defects in bacterial phagocytosis by alveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD), but the mechanisms and clinical consequences remain incompletely defined.Object

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