P113/O17 Human lymph node stromal cells express self-antigens targeted by anti-citrullinated protein antybodies: role for tolerance induction in rheumathoid arthritis

Autor: Reina E. Mebius, M Safy, Ta De Jong, Heidi Wähämaa, C. Grasso, TH Ramwadhdoebe, Anca I. Catrina, J Hähnlein, JF Semmelink, Danielle M. Gerlag, M. Maas, Reza Nadafi, Lgm van Baarsen, PP Tak

Publikováno v: Grasso, C, Hähnlein, JS, Nadafi, R, De Jong, TA, Ramwadhdoebe, TH, Semmelink, JF, Gerlag, DM, Tak, PP, Mebius, RE, Safy, M, Maas, M, Catrina, AI, Wähämaa, H & Van Baarsen, LGM 2019, ' P113/O17 Human lymph node stromal cells express self-antigens targeted by anti-citrullinated protein antybodies: role for tolerance induction in rheumathoid arthritis ' . https://doi.org/10.1136/annrheumdis-2018-ewrr2019.101

Career situation of first and presenting author Student for a master or a PhD. Introduction In rheumatoid arthritis (RA) the cause for loss of tolerance and anti–citrullinated protein antibody (ACPA) production remains unidentified. Mouse studies s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41a8b033fcb11d0b24975d2e5d1c33e
https://research.vumc.nl/en/publications/e6f60824-3369-42e9-8aaf-2f2c72ce065b

FRI0207 Induction of sustained remission in early inflammatory arthritis with the combination of infliximab plus methotrexate, methotrexate alone or placebo: the dinora trial

Autor: G.-R. Burmester, Hendrik Schulze-Koops, R. Landewe, F. C. Breedveld, Twj Huizinga, Tanja Stamm, Martin Aringer, Daniel Aletaha, Winfried Graninger, W Ebener, D. van der Heijde, Josef S Smolen, Farideh Alasti, Georg Schett, Alexandre Sepriano, Maurizio Cutolo, PP Tak, Dimitrios T. Boumpas, Klaus P Machold, Peter E. Lipsky, David S. Pisetsky

Publikováno v: Poster Presentations.

Background Rheumatoid arthritis is a chronic form of inflammatory arthritis that is thought to have an early stage or reversibility with effective therapy (“window of opportunity”). Objectives In the present study, we explored the effects of indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14413e607dc41ada41fea7ec9145aee9
https://doi.org/10.1136/annrheumdis-2017-eular.3743

SAT0037 The effects of b cell directed therapy on disease relevant biomarkers in subjects at risk of rheumatoid arthritis

Autor: Monique A.J. Janssen, L. Klareskog, S. Eyre, A. van Tubergen, N. de Vries, K. Zwinderman, Danielle M. Gerlag, M. Starmans-Kool, KI Maijer, M Safy, PP Tak, TH Ramwadhdoebe, Sander W. Tas

Publikováno v: Poster Presentations.

Background Exploration of the mechanism underlying the delay of development of clinical signs of seropositive rheumatoid arthritis (RA) observed after B cell directed therapy in individuals at risk of developing autoantibody positive RA may offer ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cddb2699715c70a3d8d2e67d6fbf8b89
https://doi.org/10.1136/annrheumdis-2017-eular.5650

Targeting the Splicing of mRNA in Autoimmune Diseases: BAFF Inhibition in Sjögren's Syndrome as a Proof of Concept

Autor: PP Tak, Patrick A. Dreyfus, Sébastien Jacques, Gilles Chiocchia, Jelle L. Vosters, Nienke Roescher, John A. Chiorini, Jean Sibilia, Ghada Alsaleh, Xavier Mariette, Jacques-Eric Gottenberg

Publikováno v: Molecular therapy, 22(4), 821-827. Nature Publishing Group

BAFF (B-cell–activating factor of the tumor necrosis factor family), a pivotal cytokine for B-cell activation, is overexpressed by salivary gland (SG) epithelial cells in primary Sjogren's syndrome (pSS). ΔBAFF, a physiological inhibitor of BAFF,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c57c8c22ee54633c09bd9e1b8a847b5

MICE LACKING FLT3L ARE PROTECTED FROM COLLAGEN-INDUCED ARTHRITIS: IMPAIRED T CELL FUNCTION?

Autor: M C Lebre, Saida Aarrass, M I Ramos, Olga N. Karpus, PP Tak, Sten Eirik W. Jacobsen

Backgroundand objectives Autoimmune diseases often result from inappropriate or unregulated activation of autoreactive T cells. The induction and maintenance of T cell tolerance to tissue antigens is essential to prevent autoimmunity. Combinations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba15776e24652272218cfe1c4aa3c8e
https://doi.org/10.1136/annrheumdis-2011-201234.12