Structuring lipid nanoparticles, DNA, and protein corona into stealth bionanoarchitectures for in vivo gene delivery.

Autor: Renzi S; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Digiacomo L; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Pozzi D; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Quagliarini E; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Vulpis E; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Giuli MV; Department of Medico-Surgical Sciences and Biotechnology, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Latina, Italy., Mancusi A; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Natiello B; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Pignataro MG; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy., Canettieri G; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Di Magno L; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Pesce L; NEST, Scuola Normale Superiore, Pisa, Italy., De Lorenzi V; NEST, Scuola Normale Superiore, Pisa, Italy., Ghignoli S; NEST, Scuola Normale Superiore, Pisa, Italy., Loconte L; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Montone CM; Department of Chemistry, Sapienza University of Rome, Rome, Italy., Laura Capriotti A; Department of Chemistry, Sapienza University of Rome, Rome, Italy., Laganà A; Department of Chemistry, Sapienza University of Rome, Rome, Italy., Nicoletti C; Unit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Rome, Italy., Amenitsch H; Institute of Inorganic Chemistry, Graz University of Technology, Graz, Austria., Rossi M; Department of Basic and Applied Sciences for Engineering and Center for Nanotechnology Applied to Engineering (CNIS), Sapienza University of Rome, Rome, Italy., Mura F; Department of Basic and Applied Sciences for Engineering and Center for Nanotechnology Applied to Engineering (CNIS), Sapienza University of Rome, Rome, Italy., Parisi G; Department of Basic and Applied Sciences for Engineering and Center for Nanotechnology Applied to Engineering (CNIS), Sapienza University of Rome, Rome, Italy., Cardarelli F; NEST, Scuola Normale Superiore, Pisa, Italy., Zingoni A; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. alessandra.zingoni@uniroma1.it., Checquolo S; Department of Medico-Surgical Sciences and Biotechnology, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Latina, Italy. saula.checquolo@uniroma1.it., Caracciolo G; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. giulio.caracciolo@uniroma1.it.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 23; Vol. 15 (1), pp. 9119. Date of Electronic Publication: 2024 Oct 23.

NaCl enhances CD8 ⁺ T cell effector functions in cancer immunotherapy.

Autor: Scirgolea C; IRCCS Humanitas Research Hospital, Milan, Italy., Sottile R; IRCCS Humanitas Research Hospital, Milan, Italy., De Luca M; IRCCS Humanitas Research Hospital, Milan, Italy., Susana A; IRCCS Humanitas Research Hospital, Milan, Italy., Carnevale S; IRCCS Humanitas Research Hospital, Milan, Italy., Puccio S; IRCCS Humanitas Research Hospital, Milan, Italy.; Institute of Genetic and Biomedical Research, UoS Milan, National Research Council, Milan, Italy., Ferrari V; IRCCS Humanitas Research Hospital, Milan, Italy., Lise V; IRCCS Humanitas Research Hospital, Milan, Italy., Contarini G; IRCCS Humanitas Research Hospital, Milan, Italy., Scarpa A; IRCCS Humanitas Research Hospital, Milan, Italy., Scamardella E; IRCCS Humanitas Research Hospital, Milan, Italy., Feno S; IRCCS Humanitas Research Hospital, Milan, Italy., Camisaschi C; IRCCS Humanitas Research Hospital, Milan, Italy., De Simone G; IRCCS Humanitas Research Hospital, Milan, Italy., Basso G; IRCCS Humanitas Research Hospital, Milan, Italy., Giuliano D; IRCCS Humanitas Research Hospital, Milan, Italy., Mazza EMC; IRCCS Humanitas Research Hospital, Milan, Italy., Gattinoni L; Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany.; University of Regensburg, Regensburg, Germany.; Center for Immunomedicine in Transplantation and Oncology (CITO), University Hospital Regensburg, Regensburg, Germany., Roychoudhuri R; Department of Pathology, University of Cambridge, Cambridge, UK.; Immunology Programme, Babraham Institute, Babraham Research Campus, Cambridge, UK., Voulaz E; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Division of Thoracic, IRCCS Humanitas Research Hospital, Milan, Italy., Di Mitri D; IRCCS Humanitas Research Hospital, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Simonelli M; IRCCS Humanitas Research Hospital, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Losurdo A; IRCCS Humanitas Research Hospital, Milan, Italy., Pozzi D; IRCCS Humanitas Research Hospital, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Tsui C; The Peter Doherty Institute for Infection and Immunity and Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia., Kallies A; The Peter Doherty Institute for Infection and Immunity and Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia., Timo S; IRCCS Humanitas Research Hospital, Milan, Italy., Martano G; IRCCS Humanitas Research Hospital, Milan, Italy.; Institute of Neuroscience, National Research Council of Italy (CNR) c/o Humanitas Mirasole S.p.A, Milan, Italy., Barberis E; Department of Sciences and Technological Innovation, University of Piemonte Orientale, Alessandria, Italy., Manfredi M; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Rescigno M; IRCCS Humanitas Research Hospital, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Jaillon S; IRCCS Humanitas Research Hospital, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy., Lugli E; IRCCS Humanitas Research Hospital, Milan, Italy. enrico.lugli@humanitasresearch.it.

Publikováno v: Nature immunology [Nat Immunol] 2024 Oct; Vol. 25 (10), pp. 1845-1857. Date of Electronic Publication: 2024 Aug 28.

PEGylation-Dependent Cell Uptake of Lipid Nanoparticles Revealed by Spatiotemporal Correlation Spectroscopy.

Autor: Digiacomo L; NanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Renzi S; NanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Pirrottina A; NanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Amenitsch H; Institute of Inorganic Chemistry, Graz University of Technology, 8010 Graz, Austria., De Lorenzi V; Laboratorio NEST, Scuola Normale Superiore, 56127 Pisa, Italy., Pozzi D; NanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy., Cardarelli F; Laboratorio NEST, Scuola Normale Superiore, 56127 Pisa, Italy., Caracciolo G; NanoDelivery Lab, Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2024 Sep 05; Vol. 7 (10), pp. 3004-3010. Date of Electronic Publication: 2024 Sep 05 (Print Publication: 2024).

FTIR spectral imaging as a probe of ultrasound effect on cells in vitro

Autor: Di Giambattista, L., Grimaldi, P., Udroiu, I., Pozzi, D., Cinque, G., Frogley, M. D., Giansanti, A., Castellano, A. Congiu

Publikováno v: Biophys. & Bioeng. Letters (2009), Vol 2, Nr 2

Safe and efficient intracellular delivery of genes or drugs is critically important in targeted cancer treatment and gene therapy applications. Ultrasound (US) has been demonstrated to alter the cell membrane permeability due to a biophysical mechani

Externí odkaz: http://arxiv.org/abs/1007.0864

Improving the accuracy of pancreatic cancer clinical staging by exploitation of nanoparticle-blood interactions: A pilot study

Autor: Caputo, D., Cartillone, M., Cascone, C., Pozzi, D., Digiacomo, L., Palchetti, S., Caracciolo, G., Coppola, R.

Publikováno v: In Pancreatology September 2018 18(6):661-665