Severe Immune Dysregulation Affects CD4+CD25hiFoxP3+ Regulatory T Cells in HIV-Infected Patients With Low-level CD4 T-Cell Repopulation Despite Suppressive Highly Active Antiretroviral Therapy.

Autor: Méndez-Lagares G, Pozo-Balado MM, Genebat M, García-Pergañeda A, Leal M, Pacheco YM

Publikováno v: Journal of Infectious Diseases; May2012, Vol. 205 Issue 10, p1501-1509, 9p

Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination.

Autor: Herrero-Fernández I; Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Avda. Manuel Siurot s/n, PC 41013, Seville, Spain., Rosado-Sánchez I; Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Avda. Manuel Siurot s/n, PC 41013, Seville, Spain., Genebat M; Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Avda. Manuel Siurot s/n, PC 41013, Seville, Spain., Tarancón-Díez L; Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Avda. Manuel Siurot s/n, PC 41013, Seville, Spain., Rodríguez-Méndez MM; Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Avda. Manuel Siurot s/n, PC 41013, Seville, Spain., Pozo-Balado MM; Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Avda. Manuel Siurot s/n, PC 41013, Seville, Spain., Lozano C; Microbiology Service, Virgen del Rocío University Hospital (HUVR), Seville, Spain., Ruiz-Mateos E; Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Avda. Manuel Siurot s/n, PC 41013, Seville, Spain., Leal M; Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Avda. Manuel Siurot s/n, PC 41013, Seville, Spain.; Internal Medicine Service, Hospital Viamed Santa Ángela de la Cruz, Seville, Spain., Pacheco YM; Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Avda. Manuel Siurot s/n, PC 41013, Seville, Spain. ypacheco-ibis@us.es.

Publikováno v: Journal of translational medicine [J Transl Med] 2018 Aug 29; Vol. 16 (1), pp. 238. Date of Electronic Publication: 2018 Aug 29.

Higher levels of IL-6, CD4 turnover and Treg frequency are already present before cART in HIV-infected subjects with later low CD4 recovery.

Autor: Rosado-Sánchez I; Laboratory of Immunovirology, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville, Seville 41013, Spain. Electronic address: isaac_rosado@hotmail.com., Jarrín I; Institute of Health Carlos III, Madrid, Spain., Pozo-Balado MM; Laboratory of Immunovirology, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville, Seville 41013, Spain., de Pablo-Bernal RS; Laboratory of Immunovirology, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville, Seville 41013, Spain., Herrero-Fernández I; Laboratory of Immunovirology, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville, Seville 41013, Spain., Alvarez-Ríos AI; Department of Clinical Biochemistry, Virgen del Rocío University Hospital IBiS/CSIC/SAS/University of Seville, Seville, Spain., Rodríguez-Gallego E; Infectious Diseases and HIV/AIDS Unit, Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain., Genebat M; Laboratory of Immunovirology, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville, Seville 41013, Spain., Vera M; Centro Sanitario Sandoval, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain., Berenguer J; Infectious Diseases and HIV Unit, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Martín ML; Infectious Diseases Service, Hospital Son Dureta, Palma de Mallorca, Spain., Bernal E; Service of Internal Medicine, Hospital Reina Sofía, Murcia, Spain., Vidal F; Infectious Diseases and HIV/AIDS Unit, Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, Tarragona, Spain., Blanco J; Institut de Recerca de la Sida IrsiCaixa-HIVACAT, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, 08916, Badalona, Spain., Leal M; Laboratory of Immunovirology, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville, Seville 41013, Spain., Pacheco YM; Laboratory of Immunovirology, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville, Seville 41013, Spain. Electronic address: ypacheco-ibis@us.es.

Publikováno v: Antiviral research [Antiviral Res] 2017 Jun; Vol. 142, pp. 76-82. Date of Electronic Publication: 2017 Mar 24.

Maraviroc reduces the regulatory T-cell frequency in antiretroviral-naive HIV-infected subjects.

Autor: Pozo-Balado MM; Laboratory of Immunovirology, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville., Martínez-Bonet M; Laboratory of Molecular Immunobiology, Hospital General Universitario Gregorio Marañon, Madrid, Spain., Rosado I; Laboratory of Immunovirology, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville., Ruiz-Mateos E; Laboratory of Immunovirology, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville., Méndez-Lagares G; Laboratory of Immunovirology, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville Department of Medical Microbiology and Immunology, University of California, Davis., Rodríguez-Méndez MM; Laboratory of Immunovirology, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville., Vidal F; Infectious Diseases and HIV/AIDS Unit, Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, Universitat Rovira i Virgili, IISPV, Spain., Muñoz-Fernández MA; Laboratory of Molecular Immunobiology, Hospital General Universitario Gregorio Marañon, Madrid, Spain., Pacheco YM; Laboratory of Immunovirology, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville., Leal M; Laboratory of Immunovirology, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2014 Sep 15; Vol. 210 (6), pp. 890-8. Date of Electronic Publication: 2014 Mar 20.

Is it age or HIV that drives the regulatory T-cells expansion that occurs in older HIV-infected persons?

Autor: Méndez-Lagares G, Leal M, del Pozo-Balado MM, León JA, Pacheco YM

Publikováno v: Clinical immunology (Orlando, Fla.) [Clin Immunol] 2010 Jul; Vol. 136 (1), pp. 157-9; author reply 160. Date of Electronic Publication: 2010 Mar 16.