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Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity.

Autor: Smith N; Translational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris, France., Possémé C; Translational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris, France., Bondet V; Translational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris, France., Sugrue J; School of Biochemistry and Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland., Townsend L; Discipline of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.; Department of Infectious Diseases, St James's Hospital, Dublin, Ireland., Charbit B; Institut Pasteur, Université Paris Cité, CBUTechS, Center for Translational Research, Paris, France., Rouilly V; Datactix, Bordeaux, France., Saint-André V; Translational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris, France.; Department of Computational Biology, Université Paris Cité, Bioinformatics and Biostatistics HUB, Institut Pasteur, Paris, France., Dott T; Institut Pasteur, Université Paris Cité, CBUTechS, Center for Translational Research, Paris, France., Pozo AR; Translational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris, France., Yatim N; Translational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris, France., Schwartz O; Department of Virology, Virus and Immunity Unit, Institut Pasteur, Paris, France., Cervantes-Gonzalez M; Infectious and Tropical Diseases Department, AP-HP, Hôpital Bichat, Paris, France.; Epidemiology, Biostatistics and Clinical Research Department, AP-HP, Hôpital Bichat, Paris, France.; Université de Paris, INSERM, IAME, UMR 1137, Paris, France., Ghosn J; Infectious and Tropical Diseases Department, AP-HP, Hôpital Bichat, Paris, France.; Université de Paris, INSERM, IAME, UMR 1137, Paris, France., Bastard P; Department of Pediatrics, Necker Hospital for Sick Children, AP-HP, Paris, France.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Casanova JL; Department of Pediatrics, Necker Hospital for Sick Children, AP-HP, Paris, France.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Université Paris Cité, Imagine Institute, Paris, France.; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Howard Hughes Medical Institute, New York, NY, USA., Szwebel TA; Institut Cochin, APHP, Paris, France., Terrier B; Institut Cochin, APHP, Paris, France., Conlon N; Department of Immunology, St James's Hospital, Dublin, Ireland.; Discipline of Immunology, School of Medicine, Trinity College Dublin, Dublin, Ireland., O'Farrelly C; School of Biochemistry and Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.; Discipline of Immunology, School of Medicine, Trinity College Dublin, Dublin, Ireland., Cheallaigh CN; Discipline of Clinical Medicine, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.; Department of Infectious Diseases, St James's Hospital, Dublin, Ireland., Bourke NM; Discipline of Medical Gerontology, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland., Duffy D; Translational Immunology Unit, Institut Pasteur, Université Paris Cité, Paris, France. darragh.duffy@pasteur.fr.; Institut Pasteur, Université Paris Cité, CBUTechS, Center for Translational Research, Paris, France. darragh.duffy@pasteur.fr.

Publikováno v: Nature communications [Nat Commun] 2022 Nov 25; Vol. 13 (1), pp. 7254. Date of Electronic Publication: 2022 Nov 25.