Development of enantioselective high-performance liquid chromatography-tandem mass spectrometry method for the quantitative determination of 3,4-methylenedioxy-methamphetamine (MDMA) and its phase-1 metabolites in human biological fluids.

Autor: Lo Faro AF; Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy., Sprega G; Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy., Beradinelli D; Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy., Tini A; Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy., Poyatos L; Servei de Farmacologia Clínica, Hospital Universitari Germans Trias i Pujol (HUGTiP, IGTP)- Universitat Aut`onoma de Barcelona, Unitat Docent HUGTiP, Badalona, Spain., Papaseit E; Servei de Farmacologia Clínica, Hospital Universitari Germans Trias i Pujol (HUGTiP, IGTP)- Universitat Aut`onoma de Barcelona, Unitat Docent HUGTiP, Badalona, Spain., Berretta P; National Centre on Addiction and Doping, Istituto Superiore di Sanit`a, Rome, Italy., Di Giorgi A; National Centre on Addiction and Doping, Istituto Superiore di Sanit`a, Rome, Italy., Farre M; Servei de Farmacologia Clínica, Hospital Universitari Germans Trias i Pujol (HUGTiP, IGTP)- Universitat Aut`onoma de Barcelona, Unitat Docent HUGTiP, Badalona, Spain., Takaishvili N; Tbilisi State University, Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, 0179 Tbilisi, Georgia., Farkas T; Phenomenex Inc., 411 Madrid Ave., Torrance 90501, CA, USA., Busardò FP; Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy. Electronic address: f.p.busardo@univpm.it., Chankvetadze B; Tbilisi State University, Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, 0179 Tbilisi, Georgia.

Publikováno v: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2024 Jan 20; Vol. 238, pp. 115768. Date of Electronic Publication: 2023 Oct 05.

GC-MS/MS Determination of Synthetic Cathinones: 4-chloromethcathinone, N-ethyl Pentedrone, and N-ethyl Hexedrone in Oral Fluid and Sweat of Consumers under Controlled Administration: Pilot Study.

Autor: Nuñez-Montero M; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallés, Spain., Lombroni C; National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy.; Department of Chemistry, Univesità degli Studi di Torino, Via Pietro Giuria 5, 10125 Torino, Italy., Maida N; National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy., Rotolo MC; National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy., Pichini S; National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy., Papaseit E; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallés, Spain., Hladun O; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallés, Spain., Ventura M; Energy Control, Associació Benestar i Desenvolupament, 08012 Barcelona, Spain., Poyatos L; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallés, Spain., Pérez-Mañá C; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallés, Spain., Farré M; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallés, Spain., Marchei E; National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 May 27; Vol. 24 (11). Date of Electronic Publication: 2023 May 27.

Sweat Testing for the Detection of Methylone after Controlled Administrations in Humans.

Autor: Di Giorgi A; Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy., Sprega G; Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy., Poyatos L; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology and Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona (UAB), 08193 Cerdanyola del Vallés, Spain., Papaseit E; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology and Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona (UAB), 08193 Cerdanyola del Vallés, Spain., Pérez-Mañá C; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology and Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona (UAB), 08193 Cerdanyola del Vallés, Spain., Di Trana A; National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy., Varì MR; National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy., Busardò FP; Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy., Pichini S; National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy., Zaami S; Department of Anatomical, Histological, Forensic, and Orthopedic Sciences, Università La Sapienza, 00161 Rome, Italy., Lo Faro AF; Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy., Farré M; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology and Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona (UAB), 08193 Cerdanyola del Vallés, Spain.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Apr 17; Vol. 24 (8). Date of Electronic Publication: 2023 Apr 17.

Pharmacological effects of methylone and MDMA in humans.

Autor: Poyatos L; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallés, Spain., Pérez-Mañá C; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallés, Spain., Hladun O; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallés, Spain., Núñez-Montero M; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallés, Spain., de la Rosa G; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallés, Spain., Martín S; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Badalona, Spain., Barriocanal AM; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Badalona, Spain., Carabias L; Department of Pharmacy, Hospital Universitari Germans Trias i Pujol (HUGTiP), Badalona, Spain., Kelmendi B; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States., Taoussi O; Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, Ancona, Italy., Busardò FP; Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, Ancona, Italy., Fonseca F; Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra, Barcelona, Spain.; Addiction Program, Institut de Neuropsiquiatria i Adiccions (INAD), Barcelona, Spain., Torrens M; Addiction Program, Institut de Neuropsiquiatria i Adiccions (INAD), Barcelona, Spain.; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallés, Spain., Pichini S; National Centre on Addiction and Doping, Istituto Superiore di Sanità, Rome, Italy., Farré M; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallés, Spain., Papaseit E; Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), Badalona, Spain.; Department of Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallés, Spain.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2023 Feb 17; Vol. 14, pp. 1122861. Date of Electronic Publication: 2023 Feb 17 (Print Publication: 2023).

MDMA interactions with pharmaceuticals and drugs of abuse

Autor: Papaseit, E, Perez-Mana, C, Torrens, M, Farre, A, Poyatos, L, Hladun, O, Sanvisens, A, Muga, R, Farre, M

Publikováno v: EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Introduction: MDMA (3,4-methylenedioxymethamphetamine), a synthetic ring-substituted amphetamine, has become one of the most widely used recreational psychostimulant drugs in the world. Among recreational ecstasy/MDMA users, polydrug use is a phenome

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