MyD88 signalling from distinct cellular compartments drives intestinal inflammation

Autor: Asquith, MJ, Boulard, O, Powrie, FM, Maloy, KJ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a262c732bf3d4aed9fca24470f58e7d9
https://ora.ox.ac.uk/objects/uuid:aec29705-0b3e-4270-8c58-6a32d6593018

A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease.

Autor: Thomas T; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Centre for Human Genetics, University of Oxford, Oxford, UK.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Friedrich M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Rich-Griffin C; Centre for Human Genetics, University of Oxford, Oxford, UK., Pohin M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Agarwal D; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Pakpoor J; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Centre for Human Genetics, University of Oxford, Oxford, UK.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Lee C; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Tandon R; University College London Hospitals NHS Foundation Trust, London, UK., Rendek A; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Aschenbrenner D; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Jainarayanan A; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Voda A; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Siu JHY; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Sanches-Peres R; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Nee E; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Sathananthan D; University of Adelaide, Adelaide, Australia.; Lyell McEwin Hospital, Adelaide, Australia., Kotliar D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Todd P; Centre for Human Genetics, University of Oxford, Oxford, UK., Kiourlappou M; Centre for Human Genetics, University of Oxford, Oxford, UK., Gartner L; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Ilott N; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Issa F; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Hester J; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Turner J; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Nayar S; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre and NIHR Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Birmingham Tissue Analytics, Institute of Translational Medicine, University of Birmingham, Birmingham, UK., Mackerodt J; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Zhang F; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Center for Health AI, University of Colorado Anschutz, Anschutz, CO, USA., Jonsson A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Brenner M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Raychaudhuri S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Kulicke R; Celsius Therapeutics, Cambridge, MA, USA., Ramsdell D; Celsius Therapeutics, Cambridge, MA, USA., Stransky N; Celsius Therapeutics, Cambridge, MA, USA., Pagliarini R; Celsius Therapeutics, Cambridge, MA, USA., Bielecki P; Celsius Therapeutics, Cambridge, MA, USA., Spies N; Celsius Therapeutics, Cambridge, MA, USA., Marsden B; Centre for Human Genetics, University of Oxford, Oxford, UK., Taylor S; Centre for Human Genetics, University of Oxford, Oxford, UK., Wagner A; Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA, USA.; The Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA., Klenerman P; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Walsh A; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK., Coles M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Jostins-Dean L; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Powrie FM; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Filer A; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre and NIHR Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.; Birmingham Tissue Analytics, Institute of Translational Medicine, University of Birmingham, Birmingham, UK., Travis S; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. simon.travis@kennedy.ox.ac.uk.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK. simon.travis@kennedy.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. simon.travis@kennedy.ox.ac.uk., Uhlig HH; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK. holm.uhlig@ndm.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. holm.uhlig@ndm.ox.ac.uk.; Department of Paediatrics, University of Oxford, Oxford, UK. holm.uhlig@ndm.ox.ac.uk., Dendrou CA; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. calliope.dendrou@kennedy.ox.ac.uk.; Centre for Human Genetics, University of Oxford, Oxford, UK. calliope.dendrou@kennedy.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. calliope.dendrou@kennedy.ox.ac.uk., Buckley CD; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. christopher.buckley@kennedy.ox.ac.uk.; Translational Gastroenterology & Liver Unit, John Radcliffe Hospital, Headington, Oxford, UK. christopher.buckley@kennedy.ox.ac.uk.; Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK. christopher.buckley@kennedy.ox.ac.uk.; NIHR Oxford Biomedical Research Centre, Oxford, UK. christopher.buckley@kennedy.ox.ac.uk.

Publikováno v: Nature immunology [Nat Immunol] 2024 Nov; Vol. 25 (11), pp. 2152-2165. Date of Electronic Publication: 2024 Oct 22.

IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies.

Autor: Friedrich M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Pohin M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Jackson MA; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Korsunsky I; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Bullers SJ; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Rue-Albrecht K; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Christoforidou Z; MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Sathananthan D; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Thomas T; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Ravindran R; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Tandon R; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Peres RS; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Sharpe H; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Wei K; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Watts GFM; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Mann EH; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Geremia A; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Attar M; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., McCuaig S; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Thomas L; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Collantes E; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Uhlig HH; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.; Department of Paediatrics, John Radcliffe Hospital, Oxford, UK., Sansom SN; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Easton A; Old Road Campus Research Building, Department of Oncology, Medical Sciences Division, University of Oxford, Oxford, UK., Raychaudhuri S; Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Centre for Genetics and Genomics Versus Arthritis, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Travis SP; Translational Gastroenterology Unit, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK., Powrie FM; Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. fiona.powrie@kennedy.ox.ac.uk.

Publikováno v: Nature medicine [Nat Med] 2021 Nov; Vol. 27 (11), pp. 1970-1981. Date of Electronic Publication: 2021 Oct 21.

IRF5 guides monocytes toward an inflammatory CD11c ⁺ macrophage phenotype and promotes intestinal inflammation.

Autor: Corbin AL; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Gomez-Vazquez M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Berthold DL; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Attar M; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Arnold IC; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.; Institut für Molekulare Krebsforschung, University of Zurich, Zurich, Switzerland., Powrie FM; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Sansom SN; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. irina.udalova@kennedy.ox.ac.uk stephen.sansom@kennedy.ox.ac.uk., Udalova IA; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. irina.udalova@kennedy.ox.ac.uk stephen.sansom@kennedy.ox.ac.uk.

Publikováno v: Science immunology [Sci Immunol] 2020 May 22; Vol. 5 (47).

Regulatory T cells and immune tolerance in the intestine.

Autor: Harrison OJ; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom., Powrie FM

Publikováno v: Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2013 Jul 01; Vol. 5 (7). Date of Electronic Publication: 2013 Jul 01.