VXX-401, a novel anti-PCSK9 vaccine, reduces LDL-C in cynomolgus monkeys

Autor: Madeline M. Vroom, Hanxin Lu, Maggie Lewis, Brett A. Thibodeaux, Jeanne K. Brooks, Matthew S. Longo, Martina M. Ramos, Jaya Sahni, Jonathan Wiggins, Justin D. Boyd, Shixia Wang, Shuang Ding, Michael Hellerstein, Valorie Ryan, Peter Powchik, Jean-Cosme Dodart

Publikováno v: Journal of Lipid Research, Vol 65, Iss 2, Pp 100497- (2024)

Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of disease burden in the world and is highly correlated with chronic elevations of LDL-C. LDL-C-lowering drugs, such as statins or monoclonal antibodies against proprotein conve

Externí odkaz: https://doaj.org/article/3293558416e04bdf9098883c37ef7a6e

Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease

Autor: Stacie Weninger, Bjorn Sperling, Robert Alexander, Magnus Ivarsson, Fiona M. Menzies, Peter Powchik, Christopher J. Weber, C. Anthony Altar, Ronald G. Crystal, Stephen J. Haggarty, Jeanne Loring, Lisa J. Bain, Maria C. Carrillo

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)

Abstract As knowledge of Alzheimer's disease (AD) progression improves, the field has recognized the need to diversify the pipeline, broaden strategies and approaches to therapies, as well as delivery mechanisms. A better understanding of the earlies

Externí odkaz: https://doaj.org/article/aad32129c56e420799a40117763c7ff7

Active immunotherapy and alternative therapeutic modalities for Alzheimer's disease.

Autor: Weninger S; FBRI Cambridge Massachusetts USA., Sperling B; H. Lundbeck A/S Copenhagen Denmark., Alexander R; Takeda Pharmaceuticals International Co. Cambridge Massachusetts USA., Ivarsson M; Rodin Therapeutics 300 Technology Square Cambridge Massachusetts USA., Menzies FM; Eli Lilly and Co, Erl Wood Manor Windlesham UK., Powchik P; United Neuroscience 9 Exchange Place, I. F. S. C Dublin Ireland., Weber CJ; Alzheimer's Association Chicago Illinois USA., Altar CA; Splice Therapeutics Bethesda Maryland USA., Crystal RG; Department of Genetic Medicine Weill Cornell Medicine New York New York USA., Haggarty SJ; Chemical Neurobiology Laboratory Center for Genomic Medicine Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA., Loring J; Scripps Research Institute La Jolla California USA., Bain LJ; Independent Science Writer Elverson Pennsylvania USA., Carrillo MC; Alzheimer's Association Chicago Illinois USA.

Publikováno v: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2020 Oct 12; Vol. 6 (1), pp. e12090. Date of Electronic Publication: 2020 Oct 12 (Print Publication: 2020).

Psychiatric Disease as a Potential Risk Factor for Dementia: A Narrative Review.

Autor: Hedges, Dawson W.^1,2 (AUTHOR) dawson_hedges@byu.edu, Chase, Morgan² (AUTHOR), Farrer, Thomas J.³ (AUTHOR) tfarrer@uidaho.edu, Gale, Shawn D.^1,2 (AUTHOR) shawn_gale@byu.edu

Publikováno v: Brain Sciences (2076-3425). Jul2024, Vol. 14 Issue 7, p722. 21p.

Longitudinal assessment of ventricular volume trajectories in early-stage schizophrenia: evidence of both enlargement and shrinkage.

Autor: Svancer, Patrik^1,2 (AUTHOR), Capek, Vaclav¹ (AUTHOR), Skoch, Antonin^1,3 (AUTHOR), Kopecek, Miloslav^1,2 (AUTHOR), Vochoskova, Kristyna^1,2 (AUTHOR), Fialova, Marketa^1,2 (AUTHOR), Furstova, Petra¹ (AUTHOR), Jakob, Lea^1,2 (AUTHOR), Bakstein, Eduard^1,4 (AUTHOR), Kolenic, Marian^1,2 (AUTHOR), Hlinka, Jaroslav¹ (AUTHOR), Knytl, Pavel^1,2 (AUTHOR), Spaniel, Filip^1,2 (AUTHOR) filip.emailiel@nudz.cz

Publikováno v: BMC Psychiatry. 4/24/2024, Vol. 24 Issue 1, p1-10. 10p.