Ultra-sensitive molecular detection of gene fusions from RNA using ASPYRE.

Autor: Gray ER; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Mordaka JM; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Christoforou ER; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., von Bargen K; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Potts ND; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Xyrafaki C; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Silva AL; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Stolarek-Januszkiewicz M; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Anton K; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Powalowska PK; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Andreazza S; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Tomassini A; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Palmer RN; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Cooke A; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Osborne RJ; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England., Balmforth BW; Biofidelity Ltd, 330 Cambridge Science Park, Milton road, CB4 0WN, Cambridge, England. b.balmforth@biofidelity.com.

Publikováno v: BMC medical genomics [BMC Med Genomics] 2022 Oct 12; Vol. 15 (1), pp. 215. Date of Electronic Publication: 2022 Oct 12.

Single-molecule DNA sequencing of widely varying GC-content using nucleotide release, capture and detection in microdroplets.

Autor: Puchtler TJ; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Johnson K; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Palmer RN; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Talbot EL; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Ibbotson LA; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Powalowska PK; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Knox R; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Shibahara A; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., M S Cunha P; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Newell OJ; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Wu M; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Chana J; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Athanasopoulou EN; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Waeber AM; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Stolarek M; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Silva AL; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Mordaka JM; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Haggis-Powell M; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Xyrafaki C; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Bush J; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Topkaya IS; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Sosna M; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Ingham RJ; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Huckvale T; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Negrea A; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Breiner B; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Šlikas J; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Kelly DJ; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Dunning AJ; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Bell NM; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Dethlefsen M; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Love DM; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Dear PH; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Kuleshova J; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Podd GJ; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Isaac TH; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Balmforth BW; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK., Frayling CA; Base 4 Innovation Ltd, Broers Building, JJ Thomson Avenue, Cambridge CB3 0FA, UK.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2020 Dec 16; Vol. 48 (22), pp. e132.

ASPYRE-Lung: validation of a simple, fast, robust and novel method for multi-variant genomic analysis of actionable NSCLC variants in FFPE tissue.

Autor: Evans, Ryan T., Gillon-Zhang, Elizabeth, Brown, Julia N., Knudsen, Katherine E., King, Candace, Green, Amanda S., Silva, Ana-Luisa, Mordaka, Justyna M., Palmer, Rebecca N., Tomassini, Alessandro, Collazos, Alejandra, Xyrafaki, Christina, Turner, Iyelola, Chau Ha Ho, Nugent, Dilyara, Jose, Jinsy, Andreazza, Simonetta, Potts, Nicola D., Bargen, Kristine von, Gray, Eleanor R.

Publikováno v: Frontiers in Oncology; 2024, p1-9, 9p

Next-Generation Sequencing Data Analysis

Autor: Xinkun Wang

Next-generation DNA and RNA sequencing has revolutionized biology and medicine. With sequencing costs continuously dropping and our ability to generate large datasets rising, data analysis becomes more important than ever. Next-Generation Sequencing