[An experimental evaluation of the therapeutic window of the neuroprotective activity of a low-molecular nerve growth factor mimetic GK-2]

Autor: Seredenin Sb, Gudasheva Ta, Povarnina Py

Publikováno v: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 118(7)

To identify the time interval for the preservation of the effect of GK-2 depending on the start of administration after modeling ischemic stroke by the transient occlusion of the middle cerebral artery in rats.The experiments were performed on 33 wil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2533600dcdc006911f5f70e28d0753e
https://pubmed.ncbi.nlm.nih.gov/30132457

Pharmacogenetic Analysis of the Interaction of the Low-Molecular-Weight BDNF Mimetic Dipeptide GSB-106 with TRK Receptors.

Autor: Antipova TA; Zakusov Research Institute of Pharmacology, Moscow, Russia., Logvinov IO; Zakusov Research Institute of Pharmacology, Moscow, Russia., Deyev IE; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia., Povarnina PY; Zakusov Research Institute of Pharmacology, Moscow, Russia., Vakhitova YV; Zakusov Research Institute of Pharmacology, Moscow, Russia., Gudasheva TA; Zakusov Research Institute of Pharmacology, Moscow, Russia. tata-sosnovka@mail.ru., Seredenin SB; Zakusov Research Institute of Pharmacology, Moscow, Russia.

Publikováno v: Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2023 Aug; Vol. 511 (1), pp. 166-168. Date of Electronic Publication: 2023 Oct 13.

A Low-Molecular-Weight BDNF Mimetic, Dipeptide GSB-214, Prevents Memory Impairment in Rat Models of Alzheimer's Disease.

Autor: Povarnina PY; Research Zakusov Institute of Pharmacology, Moscow, 125315 Russia., Volkova AA; Research Zakusov Institute of Pharmacology, Moscow, 125315 Russia.; Lomonosov Moscow State University, Faculty of Biology, Moscow, 119991 Russia., Vorontsova ON; Research Zakusov Institute of Pharmacology, Moscow, 125315 Russia., Kamensky AA; Lomonosov Moscow State University, Faculty of Biology, Moscow, 119991 Russia., Gudasheva TA; Research Zakusov Institute of Pharmacology, Moscow, 125315 Russia., Seredenin SB; Research Zakusov Institute of Pharmacology, Moscow, 125315 Russia.

Publikováno v: Acta naturae [Acta Naturae] 2022 Oct-Dec; Vol. 14 (4), pp. 94-100.

Antidepressant-like Effects of BDNF and NGF Individual Loop Dipeptide Mimetics Depend on the Signal Transmission Patterns Associated with Trk.

Autor: Mezhlumyan AG; Department of Medicinal Chemistry, V.V. Zakusov Research Institute of Pharmacology, 125315 Moscow, Russia., Tallerova AV; Department of Medicinal Chemistry, V.V. Zakusov Research Institute of Pharmacology, 125315 Moscow, Russia., Povarnina PY; Department of Medicinal Chemistry, V.V. Zakusov Research Institute of Pharmacology, 125315 Moscow, Russia., Tarasiuk AV; Department of Medicinal Chemistry, V.V. Zakusov Research Institute of Pharmacology, 125315 Moscow, Russia., Sazonova NM; Department of Medicinal Chemistry, V.V. Zakusov Research Institute of Pharmacology, 125315 Moscow, Russia., Gudasheva TA; Department of Medicinal Chemistry, V.V. Zakusov Research Institute of Pharmacology, 125315 Moscow, Russia., Seredenin SB; Department of Pharmacogenetics, V.V. Zakusov Research Institute of Pharmacology, 25315 Moscow, Russia.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Feb 24; Vol. 15 (3). Date of Electronic Publication: 2022 Feb 24.

Low-Molecular Weight BDNF Mimetic, Dimeric Dipeptide GSB-106, Reverses Depressive Symptoms in Mouse Chronic Social Defeat Stress.

Autor: Gudasheva TA; Department of Medicinal Chemistry, V.V. Zakusov Research Institute of Pharmacology, Baltijskaya 8, 125315 Moscow, Russia., Tallerova AV; Department of Medicinal Chemistry, V.V. Zakusov Research Institute of Pharmacology, Baltijskaya 8, 125315 Moscow, Russia., Mezhlumyan AG; Department of Medicinal Chemistry, V.V. Zakusov Research Institute of Pharmacology, Baltijskaya 8, 125315 Moscow, Russia., Antipova TA; Department of Pharmacogenetics, V.V. Zakusov Research Institute of Pharmacology, Baltijskaya 8, 125315 Moscow, Russia., Logvinov IO; Department of Pharmacogenetics, V.V. Zakusov Research Institute of Pharmacology, Baltijskaya 8, 125315 Moscow, Russia., Firsova YN; Department of Medicinal Chemistry, V.V. Zakusov Research Institute of Pharmacology, Baltijskaya 8, 125315 Moscow, Russia., Povarnina PY; Department of Medicinal Chemistry, V.V. Zakusov Research Institute of Pharmacology, Baltijskaya 8, 125315 Moscow, Russia., Seredenin SB; Department of Pharmacogenetics, V.V. Zakusov Research Institute of Pharmacology, Baltijskaya 8, 125315 Moscow, Russia.

Publikováno v: Biomolecules [Biomolecules] 2021 Feb 10; Vol. 11 (2). Date of Electronic Publication: 2021 Feb 10.