Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Pouria Dasmeh"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Many organismal traits are genetically determined and covary in evolving populations. The resulting trait correlations can either help or hinder evolvability – the ability to bring forth new and adaptive phenotypes. The evolution of evolva
Externí odkaz:
https://doaj.org/article/8a48b26592984692a881ccc32f48b4bc
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Understanding the molecular mechanisms of congenital diseases is challenging due to their occurrence within specific developmental stages. Esophageal malformations are examples of such conditions, characterized by abnormalities in the develo
Externí odkaz:
https://doaj.org/article/df727fc7a1214ca8a12c1d1e9661f8bd
Autor:
Mélissa K. Mariani, Pouria Dasmeh, Audray Fortin, Elise Caron, Mario Kalamujic, Alexander N. Harrison, Diana I. Hotea, Dacquin M. Kasumba, Sandra L. Cervantes-Ortiz, Espérance Mukawera, Adrian W. R. Serohijos, Nathalie Grandvaux
Publikováno v:
Cells, Vol 8, Iss 8, p 919 (2019)
Interferon (IFN) β and Tumor Necrosis Factor (TNF) are key players in immunity against viruses. Compelling evidence has shown that the antiviral and inflammatory transcriptional response induced by IFNβ is reprogrammed by crosstalk with TNF. IFNβ
Externí odkaz:
https://doaj.org/article/811b0e3d9df2455c91cf63ce5d52d40c
Autor:
Kasper P Kepp, Pouria Dasmeh
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90504 (2014)
A model of proteome-associated chemical energetic costs of cells is derived from protein-turnover kinetics and protein folding. Minimization of the proteostatic maintenance cost can explain a range of trends of proteomes and combines both protein fun
Externí odkaz:
https://doaj.org/article/377b33427a9d4c98ac0425d72bd2fbec
Autor:
Pouria Dasmeh, Kasper P Kepp
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e80308 (2013)
Myoglobin (Mb) is a centrally important, widely studied mammalian protein. While much work has investigated multi-step unfolding of apoMb using acid or denaturant, holomyoglobin unfolding is poorly understood despite its biological relevance. We pres
Externí odkaz:
https://doaj.org/article/4115b52d84cf4db3a3644eabc1f6c225
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 3, p e1002929 (2013)
Since divergence ∼50 Ma ago from their terrestrial ancestors, cetaceans underwent a series of adaptations such as a ∼10-20 fold increase in myoglobin (Mb) concentration in skeletal muscle, critical for increasing oxygen storage capacity and prolo
Externí odkaz:
https://doaj.org/article/ae0a721f750a47af826e531bf39ae6e4
Autor:
Ayşe N. Erdoğan, Pouria Dasmeh, Raymond D. Socha, John Z. Chen, Ben Life, Rachel Jun, Linda Kiritchkov, Dan Kehila, Adrian W.R. Serohijos, Nobuhiko Tokuriki
Phenotypic variations within a population exist on different scales of biological organization and play a central role in evolution by providing adaptive capacity at the population-level. Thus, the question of how evolution generates phenotypic varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0e4da144f20356694589af31535b85
https://doi.org/10.1101/2023.04.05.535609
https://doi.org/10.1101/2023.04.05.535609
Assemblies of multivalent RNA-binding protein FUS can exist in the functional liquid-like state as well as less dynamic and potentially toxic amyloid- and hydrogel-like states. How could then cells form liquid-like condensates while avoiding their tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4c415c08279cca0cc21adb008ca348
https://doi.org/10.1101/2022.09.15.508150
https://doi.org/10.1101/2022.09.15.508150
Many organismal traits are genetically determined and covary in evolving populations. The resulting trait correlations can either help or hinder evolvability – the ability to bring forth new and adaptive phenotypes. The evolution of evolvability re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba32b3c4129f7d891a9044fc2fab86bd
https://doi.org/10.1101/2022.05.05.490716
https://doi.org/10.1101/2022.05.05.490716
Autor:
Giuseppe Semplicio, Claudia Isabelle Keller Valsecchi, Pouria Dasmeh, Aline Gaub, Janine Seyfferth, Amol Panhale, Asifa Akhtar, Plamen Georgiev, Tanvi Kulkarni, Herbert Holz, M. Felicia Basilicata, Vinitha Manjunath
Publikováno v:
Nature
Confinement of the X chromosome to a territory for dosage compensation is a prime example of how subnuclear compartmentalization is used to regulate transcription at the megabase scale. In Drosophila melanogaster, two sex-specific non-coding RNAs (ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acd6b55e4401d62526f17fdf12d8d01
https://doi.org/10.1038/s41586-020-2935-z
https://doi.org/10.1038/s41586-020-2935-z