Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci

Autor: Ahluwalia, TS, Prins, BP, Abdollahi, M, Armstrong, NJ, Aslibekyan, S, Bain, L, Jefferis, B, Baumert, J, Beekman, M, Ben-Shlomo, Y, Bis, JC, Mitchell, BD, de Geus, E, Delgado, GE, Marek, D, Eriksson, J, Kajantie, E, Kanoni, S, Kemp, JP, Lu, C, Marioni, RE, McLachlan, S, Milaneschi, Y, Nolte, IM, Petrelis, AM, Porcu, E, Sabater-Lleal, M, Naderi, E, Seppälä, I, Shah, T, Singhal, G, Standl, M, Teumer, A, Thalamuthu, A, Thiering, E, Trompet, S, Ballantyne, CM, Benjamin, EJ, Casas, JP, Toben, C, Dedoussis, G, Deelen, J, Durda, P, Engmann, J, Feitosa, MF, Grallert, H, Hammarstedt, A, Harris, SE, Homuth, G, Hottenga, J-J, Jalkanen, S, Jamshidi, Y, Jawahar, MC, Jess, T, Kivimaki, M, Kleber, ME, Lahti, J, Liu, Y, Marques-Vidal, P, Mellström, D, Mooijaart, SP, Müller-Nurasyid, M, Penninx, B, Revez, JA, Rossing, P, Räikkönen, K, Sattar, N, Scharnagl, H, Sennblad, B, Silveira, A, Pourcain, BS, Timpson, NJ, Trollor, J, CHARGE Inflammation Working Group, van Dongen, J, Van Heemst, D, Visvikis-Siest, S, Vollenweider, P, Völker, U, Waldenberger, M, Willemsen, G, Zabaneh, D, Morris, RW, Arnett, DK, Baune, BT, Boomsma, DI, Chang, Y-PC, Deary, IJ, Deloukas, P, Eriksson, JG, Evans, DM, Ferreira, MA, Gaunt, T, Gudnason, V, Hamsten, A, Heinrich, J, Hingorani, A, Humphries, SE, Jukema, JW, Koeing, W, Kumari, M, Kutalik, Z, Lawlor, DA, Lehtimäki, T, März, W, Mather, K, Naitza, S, Nauck, M, Ohlsson, C, Price, JF, Raitakari, O, Rice, K, Sachdev, PS, Slagboom, E, Sørensen, TIA, Spector, T, Stacey, D, Stathopoulou, MG, Tanaka, T, Wannamethee, SG, Whincup, P, Rotter, JI, Dehghan, A, Boerwinkle, E, Psaty, BM, Snieder, H, Alizadeh, BZ

Interleukin-6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::043796f2040210709135c769baeddf98
https://openaccess.sgul.ac.uk/id/eprint/112959/9/ddab023.pdf

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

Autor: D. L. Cousminer, D. J. Berry, N. J. Timpson, W. Ang, E. Thiering, E. M. Byrne, H. R. Taal, V. Huikari, J. P. Bradfield, M. Kerkhof, M. M. Groen Blokhuis, E. Kreiner Moller, M. Marinelli, C. Holst, J. T. Leinonen, J. R. B. Perry, I. Surakka, O. Pietilainen, J. Kettunen, V. Anttila, M. Kaakinen, U. Sovio, A. Pouta, S. Das, V. Lagou, C. Power, I. Prokopenko, D. M. Evans, J. P. Kemp, B. St Pourcain, S. Ring, A. Palotie, E. Kajantie, C. Osmond, T. Lehtimaki, J. S. Viikari, M. Kahonen, N. M. Warrington, S. J. Lye, L. J. Palmer, C. M. T. Tiesler, C. Flexeder, G. W. Montgomery, S. E. Medland, A. Hofman, H. Hakonarson, M. Guxens, M. Bartels, V. Salomaa, J. M. Murabito, J. Kaprio, T. I. A. Sorensen, F. Ballester, H. Bisgaard, D. I. Boomsma, G. H. Koppelman, S. F. A. Grant, V. W. V. Jaddoe, N. G. Martin, J. Heinrich, C. E. Pennell, O. T. Raitakari, J. G. Eriksson, G. D. Smith, E. Hypponen, M. R. Jarvelin, M. I. McCarthy, S. Ripatti, E. Widen, Adair LS, Ang W, Atalay M, van Beijsterveldt T, Bergen N, Benke K, Berry DJ, Boomsma DI, Bradfield JP, Charoen P, Coin L, Cooper C, Cousminer DL, Das S, Davis OS, Dedoussis GV, Elliott P, Estivill X, Evans DM, Feenstra B, Flexeder C, Frayling T, Freathy RM, Gaillard R, Geller F, Gillman M, Grant SF, Groen Blokhuis M, Goh LK, Guxens M, Hakonarson H, Hattersley AT, Haworth CM, Hadley D, Hedebrand J, Heinrich J, Hinney A, Hirschhorn JN, Hocher B, Holloway JW, Holst C, Hottenga JJ, Horikoshi M, Huikari V, Hypponen E, Iñiguez C, Jaddoe VW, Jarvelin MR, Kaakinen M, Kilpeläinen TO, Kirin M, Kowgier M, Lakka HM, Lakka TA, Lange LA, Lawlor DA, Lehtimäki T, Lewin A, Lindgren C, Lindi V, Maggi R, Marsh J, McCarthy MI, Melbye M, Middeldorp C, Millwood I, Mohlke KL, Mook Kanamori DO, Murray JC, Nivard M, Nohr EA, Ntalla I, Oken E, Ong KK, O'Reilly PF, Palmer LJ, Panoutsopoulou K, Pararajasingham J, Pearson ER, Pennell CE, Power C, Price TS, Prokopenko I, Raitakari OT, Rodriguez A, Salem RM, Saw SM, Scherag A, Sebert S, Siitonen N, Simell O, Sørensen TI, Sovio U, Pourcain BS, Strachan DP, Sunyer J, Taal HR, Teo YY, Thiering E, Tiesler C, Timpson NJ, Uitterlinden AG, Valcárcel B, Warrington NM, White S, Widén E, Willemsen G, Wilson JF, Yaghootkar H, Zeggini E, Elks CE, Perry JR, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Gudbjartsson DF, Esko T, Koller DL, Kutalik Z, Lin P, Mangino M, Marongiu M, McArdle PF, Smith AV, Stolk L, van Wingerden SH, Zhao JH, Albrecht E, Corre T, Ingelsson E, Hayward C, Magnusson PK, Smith EN, Ulivi S, Warrington M, Zgaga L, Alavere H, Amin N, Aspelund T, Bandinelli S, Barroso I, Berenson GS, Bergmann S, Blackburn H, Boerwinkle E, Buring JE, Busonero F, Campbell H, Chanock SJ, Chen W, Cornelis MC, Couper D, Coviello AD, de Faire U, de Geus EJ, Deloukas P, Döring A, Davey Smith G, Easton DF, Eiriksdottir G, Emilsson V, Eriksson J, Ferrucci L, Folsom AR, Foroud T, Garcia M, GASPARINI, PAOLO, Gieger C, Gudnason V, Hall P, Hankinson SE, Ferreli L, Heath AC, Hernandez DG, Hofman A, Hu FB, Illig T, Järvelin MR, Johnson AD, Karasik D, Khaw KT, Kiel DP, Kolcic I, Kraft P, Launer LJ, Laven JS, Li S, Liu J, Levy D, Martin NG, McArdle WL, Mooser V, Murray SS, Nalls MA, Navarro P, Nelis M, Ness AR, Northstone K, Oostra BA, Peacock M, Palotie A, Paré G, Parker AN, Pedersen NL, Peltonen L, Pharoah P, Polasek O, Plump AS, Pouta A, Porcu E, Rafnar T, Rice JP, Ring SM, Rivadeneira F, Rudan I, Sala C, Salomaa V, Sanna S, Schlessinger D, Schork NJ, Scuteri A, Segrè AV, Shuldiner AR, Soranzo N, Srinivasan SR, Tammesoo ML, Tikkanen E, Toniolo D, Tsui K, Tryggvadottir L, Tyrer J, Uda M, van Dam RM, van Meurs JB, Vollenweider P, Waeber G, Wareham NJ, Waterworth DM, Weedon MN, Wichmann HE, Wright AF, Young L, Zhai G, Zhuang WV, Bierut LJ, Boyd HA, Crisponi L, Demerath EW, van Duijn CM, Econs MJ, Harris TB, Hunter DJ, Loos RJ, Metspalu A, Montgomery GW, Ridker PM, Spector TD, Streeten EA, Stefansson K, Thorsteinsdottir U, Widen E, Murabito JM, Murray A., D'ADAMO, ADAMO PIO

Publikováno v: Human Molecular Genetics Vol. 22 Issue 13: pp. 2735-2747
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
Human Molecular Genetics
Hum. Mol. Genet. 22, 2735-2747 (2013)
HUMAN MOLECULAR GENETICS
r-FISABIO. Repositorio Institucional de Producción Científica
Human Molecular Genetics; Vol 22
Cousminer, D L, Berry, D J, Timpson, N J, Ang, W, Thiering, E, Byrne, E M, Taal, H R, Huikari, V, Bradfield, J P, Kerkhof, M, Groen-Blokhuis, M M, Kreiner-Møller, E, Marinelli, M, Holst, C, Leinonen, J T, Perry, J R, Surakka, I, Pietilainen, O P, Kettunen, J, Anttila, V, Kaakinen, M, Sovio, U, Pouta, A, Das, S, Lagou, V, Power, C, Prokopenko, I, Evans, D M, Kemp, J P, St Pourcain, B, Ring, S M, Palotie, A, Kajantie, E, Osmond, C, Lehtimäki, T, Viikari, J S, Kähönen, M, Warrington, N M, Lye, S J, Palmer, L J, Tiesler, C M T, Flexeder, C, Montgomery, G W, Medland, S E, Hofman, A, Hakonarson, H, Guxens, M, Bartels, M, Salomaa, V, Adair, L S, Atalay, M, van Beijsterveldt, C E M, Bergen, N, Benke, K S, Charoen, P, Coin, L, Cooper, C, Davis, O S, Dedoussis, G V, Elliott, P, Estivill, X, Feenstra, B, Frayling, T M, Freathy, R M, Gaillard, R, Geller, F, Gillman, M W, Goh, L K, Hattersley, A T, Haworth, C M, Hadley, D, Hedebrand, J, Hinney, A, Hirschhorn, J N, Hocher, B, Holloway, J W, Hottenga, J J, Horikoshi, M, Iñiguez, C, Järvelin, M R, Kilpeläinen, T O, Kirin, M, Kowgier, M, Lakka, H M, Lakka, T A, Lange, L A, Lawlor, D A, Lewin, A, Lindgren, C M, Lindi, V, Maggi, R, Marsh, J, Melbye, M, Middeldorp, C M, Millwood, I, Mohlke, K L, Mook-Kanamori, D O, Murray, J C, Nivard, M G, Nohr, E A, Ntalla, I, Oken, E, Ong, K K, O'Reilly, P F, Panoutsopoulou, K, Pararajasingham, J, Pearson, E R, Price, T S, Rodriguez, A, Salem, R M, Saw, S M, Scherag, A, Sebert, S, Siitonen, N, Simell, O, Strachan, D P, Sunyer, J, Teo, Y Y, Uitterlinden, A G, Valcárcel, B, White, S, Widén, E, Willemsen, G, Wilson, J F, Yaghootkar, H, Zeggini, E, Elks, C E, Sulem, P, Chasman, D I, Franceschini, N, He, C, Lunetta, K L, Visser, J A, Gudbjartsson, D F, Esko, T, Koller, D L, Kutalik, Z, Lin, P, Mangino, M, Marongiu, M, McArdle, P F, Smith, A V, Stolk, L, van Wingerden, S, Zhao, J H, Albrecht, E, Corre, T, Ingelsson, E, Hayward, C, Magnusson, P K E, Smith, E N, Ulivi, S, Warrington, M, Zgaga, L, Alavere, H, Amin, N, Aspelund, T, Bandinelli, S, Barroso, I, Berenson, G S, Bergmann, S, Blackburn, H, Boerwinkle, E, Buring, J E, Busonero, F, Campbell, H, Chanock, S J, Chen, W, Cornelis, M C, Couper, D, Coviello, A D, d'Adamo, P, de Faire, U, de Geus, E J C, Deloukas, P, Döring, A, Davey Smith, G, Easton, D F, Eiriksdottir, G, Emilsson, V, Ferrucci, L, Folsom, A R, Foroud, T, Garcia, M, Gasparini, P, Gieger, C, Gudnason, V, Hall, P, Hankinson, S E, Ferreli, L, Heath, A C, Hernandez, D G, Hu, F B, Illig, T, Johnson, A D, Karasik, D, Khaw, K T, Kiel, D P, Kolcic, I, Kraft, P, Launer, L J, Laven, J S, Li, S, Liu, J, Levy, D, McArdle, W L, Mooser, V, Murray, S S, Nalls, M A, Navarro, P, Nelis, M, Ness, A R, Northstone, K, Oostra, B A, Peacock, M, Paré, G, Parker, A N, Pedersen, N L, Peltonen, L, Pennell, C E, Pharoah, P, Polasek, O, Plump, A S, Porcu, E, Rafnar, T, Rice, J P, Rivadeneira, F, Rudan, I, Sala, C, Sanna, S, Schlessinger, D, Schork, N J, Scuteri, A, Segrè, A V, Shuldiner, A R, Soranzo, N, Srinivasan, S R, Tammesoo, M L, Tikkanen, E, Toniolo, D, Tsui, K, Tryggvadottir, L, Tyrer, J, Uda, M, Dam, R M, van Meurs, J B, Vollenweider, P, Waeber, G, Wareham, N J, Waterworth, D, Weedon, M N, Wichmann, H E, Wright, A F, Young, L, Zhai, G, Zhuang, W V, Bierut, L J, Boyd, H A, Crisponi, L, Demerath, E W, van Duijn, C M, Econs, M J, Harris, T B, Hunter, D J, Loos, R J, Metspalu, A, Ridker, P M, Spector, T D, Streeten, E A, Stefansson, K, Thorsteinsdottir, U, Murray, A, Murabito, J M, Kaprio, J, Sørensen, T I A, Ballester, F, Bisgaard, H, Boomsma, D I, Koppelman, G H, Grant, S F, Jaddoe, V W, Martin, N G, Heinrich, J, Raitakari, O T, Eriksson, J G, Smith, G D, Hyppönen, E, McCarthy, M I & Ripatti, S 2013, ' Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth pubertal timing and childhood adiposity ', Human Molecular Genetics, vol. 22, no. 13, pp. 2735-2747 . https://doi.org/10.1093/hmg/ddt104
Human Molecular Genetics, 22(13), 2735-2747. Oxford University Press
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)

The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b26d537e0fd4cd246c06c21c1a378f
https://hdl.handle.net/1959.8/152978

Discovery of 42 genome-wide significant loci associated with dyslexia.

Autor: Doust C; Department of Psychology, University of Edinburgh, Edinburgh, UK., Fontanillas P; 23andMe, Inc., Sunnyvale, CA, USA., Eising E; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands., Gordon SD; Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Wang Z; School of Psychology, Shaanxi Normal University and Shaanxi Key Research Center of Child Mental and Behavioral Health, Xi'an, China., Alagöz G; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands., Molz B; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands., Pourcain BS; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK., Francks C; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Zhao J; School of Psychology, Shaanxi Normal University and Shaanxi Key Research Center of Child Mental and Behavioral Health, Xi'an, China., Paracchini S; School of Medicine, University of St Andrews, St Andrews, UK., Talcott JB; Institute of Health and Neurodevelopment, Aston University, Birmingham, UK., Monaco AP; Office of the President, Tufts University, Medford, MA, USA., Stein JF; Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK., Gruen JR; Departments of Pediatrics and Genetics, Yale Medical School, New Haven, CT, USA., Olson RK; Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA., Willcutt EG; Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA., DeFries JC; Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA., Pennington BF; Department of Psychology, University of Denver, Denver, CO, USA., Smith SD; Department of Neurological Sciences, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA., Wright MJ; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Martin NG; Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Auton A, Bates TC; Department of Psychology, University of Edinburgh, Edinburgh, UK., Fisher SE; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands., Luciano M; Department of Psychology, University of Edinburgh, Edinburgh, UK. michelle.luciano@ed.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2022 Nov; Vol. 54 (11), pp. 1621-1629. Date of Electronic Publication: 2022 Oct 20.

Genome-wide association study of circulating interleukin 6 levels identifies novel loci.

Autor: Ahluwalia TS; Steno Diabetes Center Copenhagen, Gentofte DK2820, Denmark.; Department of Biology, The Bioinformatics Center, University of Copenhagen, Copenhagen DK2200, Denmark., Prins BP; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, The Netherlands., Abdollahi M; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, The Netherlands., Armstrong NJ; Mathematics and Statistics, Murdoch University, Perth 6150, Australia., Aslibekyan S; Department of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, Alabama 35233, USA., Bain L; QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia., Jefferis B; Department of Primary Care & Population Health, UCL Institute of Epidemiology & Health Care, University College London, London NW3 2PF, UK., Baumert J; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany., Beekman M; Department of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands., Ben-Shlomo Y; Population Health Sciences, University of Bristol, Bristol BS8 2PS, UK., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21202, USA., de Geus E; Department of Biological Psychology, Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 BT, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam 1105 AZ, The Netherlands., Delgado GE; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim 68167, Germany., Marek D; SIB Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland., Eriksson J; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, Centre for Bone and Arthritis Research (CBAR), University of Gothenburg, Gothenburg 41345, Sweden., Kajantie E; Chronic Disease Prevention Unit, National Institute for Health and Welfare, PO Box 30, Helsinki 00271, Finland.; Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki 00014, Finland., Kanoni S; William Harvey Research Institute, Barts & the London Medical School, Queen Mary University of London, London EC1M 6BQ, UK., Kemp JP; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland 4102, Australia.; MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol BS8 2BN, UK., Lu C; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK., McLachlan S; Usher Institute, University of Edinburgh, Edinburgh EH8 9AG, UK., Milaneschi Y; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam 1081 HJ, The Netherlands., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, The Netherlands., Petrelis AM; Université de Lorraine, Inserm, IGE-PCV, Nancy 54000, France., Porcu E; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato (CA) 09042, Italy., Sabater-Lleal M; Cardiovascular Medicine, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden.; Unit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau (IIB-Sant Pau), Barcelona 08041, Spain., Naderi E; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, The Netherlands., Seppälä I; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33520, Finland., Shah T; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK., Singhal G; Discipline of Psychiatry, Adelaide Medical School, University of Adelaide, Adelaide 5005, Australia., Standl M; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany., Thalamuthu A; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia., Thiering E; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; Division of Metabolic Diseases and Nutritional Medicine, Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Munich 80337, Germany., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands., Ballantyne CM; Baylor College of Medicine, Houston, TX 77030, USA., Benjamin EJ; National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA 01702, USA.; Section of Cardiovascular Medicine and Preventive Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA., Casas JP; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA 02130, USA., Toben C; Discipline of Psychiatry, Adelaide Medical School, University of Adelaide, Adelaide 5005, Australia., Dedoussis G; 44Department of Nutrition-Dietetics, Harokopio University, Athens 17671, Greece., Deelen J; Department of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Max Planck Institute for Biology of Ageing, Cologne 50931, Germany., Durda P; Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT 05405, USA., Engmann J; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110-1093, USA., Grallert H; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; German Center for Diabetes Research (DZD), Neuherberg 85764, Germany., Hammarstedt A; The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg SE-41345, Sweden., Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17475, Germany., Hottenga JJ; Department of Biological Psychology, Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 BT, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam 1105 AZ, The Netherlands., Jalkanen S; MediCity Research Laboratory, University of Turku, Turku 20520, Finland.; Department of Medical Microbiology and Immunology, University of Turku, Turku 20520, Finland., Jamshidi Y; Genetics Research Centre, Molecular and Clinical Sciences Institute, St George's University of London, London SW17 0RE, UK., Jawahar MC; Discipline of Psychiatry, Adelaide Medical School, University of Adelaide, Adelaide 5005, Australia., Jess T; 55Department of Epidemiology Research, Statens Serum Institute, Copenhagen DK2300, Denmark., Kivimaki M; Department of Epidemiology & Public Health, UCL Institute of Epidemiology & Health Care, University College London, London WC1E 7HB, UK., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim 68167, Germany., Lahti J; Turku Institute for Advanced Studies, University of Turku, Turku 20014, Finland.; Department of Psychology and Logopedics, University of Helsinki, Helsinki 00014, Finland., Liu Y; Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA., Marques-Vidal P; Department of Internal Medicine, Lausanne University Hospital (CHUV), Lausanne 1011, Switzerland.; University of Lausanne, Lausanne 1011, Switzerland., Mellström D; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, Centre for Bone and Arthritis Research (CBAR), University of Gothenburg, Gothenburg 41345, Sweden., Mooijaart SP; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands., Müller-Nurasyid M; IBE, Faculty of Medicine, Ludwig Maximilians University (LMU) Munich, Munich 81377, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johhanes Gutenberg University, Mainz 55101, Germany., Penninx B; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam 1081 HJ, The Netherlands., Revez JA; QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia., Rossing P; Steno Diabetes Center Copenhagen, Gentofte DK2820, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen DK2200, Denmark., Räikkönen K; Department of Psychology and Logopedics, University of Helsinki, Helsinki 00014, Finland., Sattar N; BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow G12 8TA, UK., Scharnagl H; 66Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria., Sennblad B; Cardiovascular Medicine, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden.; Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala 75124, Sweden., Silveira A; Cardiovascular Medicine, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Pourcain BS; MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol BS8 2BN, UK.; Max Planck Institute for Psycholinguistics, Nijmegen XD 6525, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen 6525 AJ, The Netherlands., Timpson NJ; MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol BS8 2BN, UK., Trollor J; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia.; Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney 2031, Australia., van Dongen J; Department of Biological Psychology, Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 BT, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam 1105 AZ, The Netherlands., Van Heemst D; Baylor College of Medicine, Houston, TX 77030, USA., Visvikis-Siest S; Université de Lorraine, Inserm, IGE-PCV, Nancy 54000, France., Vollenweider P; Department of Internal Medicine, Lausanne University Hospital (CHUV), Lausanne 1011, Switzerland.; University of Lausanne, Lausanne 1011, Switzerland., Völker U; MediCity Research Laboratory, University of Turku, Turku 20520, Finland., Waldenberger M; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany., Willemsen G; Department of Biological Psychology, Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 BT, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam 1105 AZ, The Netherlands., Zabaneh D; Department of Genetics, Environment and Evolution, University College London Genetics Institute, London WC1E 6BT, UK., Morris RW; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1UD, UK., Arnett DK; Dean's Office, College of Public Health, University of Kentucky, Lexington, KY 40536, USA., Baune BT; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Parkville 3000, Australia.; Department of Psychiatry and Psychotherapy, University of Muenster, Muenster 48149, Germany.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville 3000, Australia., Boomsma DI; Department of Biological Psychology, Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 BT, The Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam 1105 AZ, The Netherlands., Chang YC; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21202, USA., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK., Deloukas P; William Harvey Research Institute, Barts & the London Medical School, Queen Mary University of London, London EC1M 6BQ, UK.; 77Centre for Genomic Health, Queen Mary University of London, London EC1M 6BQ, UK., Eriksson JG; National Institute for Health and Welfare, University of Helsinki, Helsinki 00014, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, Helsinki 00014, Finland., Evans DM; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, Queensland 4102, Australia.; MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol BS8 2BN, UK., Ferreira MA; QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia., Gaunt T; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol BS6 2BN, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK., Gudnason V; Icelandic Heart Association, Kópavogur 201, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., Hamsten A; Cardiovascular Medicine, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden., Heinrich J; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.; Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich 81377, Germany.; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne 3010, Australia., Hingorani A; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK., Humphries SE; Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK., Jukema JW; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.; Durrer Center for Cardiogenetic Research, Amsterdam 1105 AZ, The Netherlands., Koenig W; Deutsches Herzzentrum München, Technische Universität München, Munich 80636, Germany.; 88DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich 80336, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm 89081, Germany., Kumari M; Department of Epidemiology & Public Health, UCL Institute of Epidemiology & Health Care, University College London, London WC1E 7HB, UK.; Institute for Social and Economic Research, University of Essex, Colchester CO4 3SQ, Germany., Kutalik Z; SIB Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.; University Center for Primary Care and Public Health, University of Lausanne, Lausanne 1010, Switzerland., Lawlor DA; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol BS6 2BN, UK.; Population Health Science, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere 33520, Finland., März W; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim 68167, Germany.; 66Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.; SYNLAB Academy, SYNALB Holding Deutschland GmbH, Mannheim 68163, Germany., Mather KA; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia.; Neuroscience Research Australia, Sydney 2031, Australia., Naitza S; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato (CA) 09042, Italy., Nauck M; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald 17475, Germany.; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany., Ohlsson C; Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, Centre for Bone and Arthritis Research (CBAR), University of Gothenburg, Gothenburg 41345, Sweden., Price JF; Usher Institute, University of Edinburgh, Edinburgh EH8 9AG, UK., Raitakari O; Centre for Population Health Research, University of Turku, Turku University Hospital, Turku 20520, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20014, Finland., Rice K; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA., Sachdev PS; Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney 2052, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, Sydney 2031, Australia., Slagboom E; Department of Biomedical Data Sciences, Section of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.; Max Planck Institute for Biology of Ageing, Cologne 50931, Germany., Sørensen TIA; Novo Nordisk Foundation Center For Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK2200, Denmark.; Department of Public Health, Section on Epidemiology, University of Copenhagen, Copenhagen DK1014, Denmark., Spector T; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Stacey D; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Stathopoulou MG; Université de Lorraine, Inserm, IGE-PCV, Nancy 54000, France., Tanaka T; Longitudinal Study Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA., Wannamethee SG; Department of Primary Care & Population Health, UCL Institute of Epidemiology & Health Care, University College London, London NW3 2PF, UK., Whincup P; Population Health Research Institute, St George's, University of London, London SW17 0RE, UK., Rotter JI; Department of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Dehghan A; Department of Epidemiology, Erasmus MC, Rotterdam 3000 CA, The Netherlands., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.; Departments of Epidemiology and Health Services, University of Washington, Seattle, WA 98101, USA., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, The Netherlands., Alizadeh BZ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, The Netherlands.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2021 Apr 27; Vol. 30 (5), pp. 393-409.

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.

Autor: Lagou V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Department of Microbiology and Immunology, Laboratory of Adaptive Immunity, KU Leuven, Leuven, Belgium.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, the Netherlands., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD, München-Neuherberg, Germany., Perry JRB; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Bouatia-Naji N; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; INSERM U970, Paris Cardiovascular Research Center PARCC, 75006, Paris, France., Marullo L; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Rybin D; Boston University Data Coordinating Center, Boston, MA, USA., Jansen R; Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands., Min JL; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Dimas AS; Institute for Bioinnovation, Biomedical Sciences Research Center Al. Fleming, Vari, Greece., Ulrich A; Department of Medicine, Imperial College London, London, UK., Zudina L; Department of Medicine, Imperial College London, London, UK., Gådin JR; Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden., Jiang L; Department of Medicine, Imperial College London, London, UK.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Faggian A; Department of Medicine, Imperial College London, London, UK., Bonnefond A; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Department of Medicine, Imperial College London, London, UK., Fadista J; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Stathopoulou MG; Université de Lorraine, IGE-PCV, F-54000, Nancy, France., Isaacs A; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio, Maastricht University, Maastricht, the Netherlands.; Department of Physiology, Maastricht University, Maastricht, the Netherlands., Willems SM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Navarro P; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Tanaka T; Translational Gerontology Branch, Longitudinal Study Section, National Institute on Aging, Baltimore, MD, USA., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Montasser ME; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA., O'Connell JR; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Webster RJ; Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research, University of Western Australia Centre for Medical Research, Nedlands, WA, Australia., Saxena R; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Departmentartment of Anesthesia, Critical Care and Pain Medicine, MGH, Boston, MA, USA., Stafford JM; Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Pourcain BS; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Salo P; Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland., Shin SY; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Amin N; Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands., Smith AV; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Li G; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Johnson PCD; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.; Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow, UK., Johnson T; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Kapur K; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland., Thorleifsson G; deCODE Genetics, Reykjavik, Iceland., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mihailov E; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Fall T; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Fraser RM; Usher Institute, University of Edinburgh, Edinburgh, UK.; Synpromics Ltd, Roslin Innovation Centre, Easter Bush Campus, Edinburgh, EH25 9RG, UK., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Wellcome Trust Sanger Institute, Hinxton, UK., Giedraitis V; Department of Public Health and Caring Sciences, Uppsala Universitet, Uppsala, Sweden., Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Silbernagel G; Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Meyer J; Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology and Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI, University Medical Center, Johannes Gutenberg University, 55101, Mainz, Germany., Ganna A; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sarin AP; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Public Health Genomics Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Yengo L; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia., Shungin D; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Odontology, Umeå University, Umeå, Sweden., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Horikoshi M; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; RIKEN, Center for Integrative Medical Sciences, Laboratory for Endocrinology, Metabolism and Kidney Disease, Yokohama, Japan., An P; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Sanna S; Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Boettcher Y; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Rayner NW; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Wellcome Trust Sanger Institute, Hinxton, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Zemunik T; Faculty of Medicine, University of Split, Split, Croatia., Iperen EV; Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands., Kovacs P; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Hastie ND; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Wild SH; Usher Institute, University of Edinburgh, Edinburgh, UK., McLachlan S; Usher Institute, University of Edinburgh, Edinburgh, UK., Campbell S; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Polasek O; Faculty of Medicine, University of Split, Split, Croatia., Carlson O; Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA., Egan J; Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA., Kiess W; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Pediatric Research Center, Department of Women's & Child Health, University of Leipzig, Leipzig, Germany., Willemsen G; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Dimitriou M; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Hicks AA; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Bandinelli S; Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy., Thorand B; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Liu Y; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Miljkovic I; Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA., Lind L; Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, Uppsala, Sweden., Doney A; Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Perola M; Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Hingorani A; Department of Epidemiology and Public Health, University College London, London, UK., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK., Kumari M; Department of Epidemiology and Public Health, University College London, London, UK.; University of Essex, Wivenhoe Park, Colchester, Essex, UK., Bennett AJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Groves CJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK., Herder C; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Koistinen HA; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, P.O. Box 340, Haartmaninkatu 4, Helsinki, FI-00029, Finland.; Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, Helsinki, FI-00290, Finland., Kinnunen L; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Faire U; Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Bakker SJL; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Uusitupa M; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Palmer CNA; Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Jukema JW; Dept of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom., Pouta A; Department of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland.; PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Boerwinkle E; IMM Center for Human Genetics, University of Texas Health Science Center at Houston, Houston, TX, USA.; Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MiI, USA., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Krus U; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden., Scapoli C; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., de Geus EJCN; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, the Netherlands., Blüher M; Department of Medicine, University of Leipzig, Leipzig, Germany.; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Wolffenbuttel BHR; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Province MA; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Abecasis GR; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Meigs JB; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; General Medicine Division, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hovingh GK; Department of Vascular Medicine, Amsterdam UMC, Amsterdam, the Netherlands.; Novo Nordisk A/S, Copenhagen, Denmark., Lindström J; Finnish Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland., Wilson JF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK., Wright AF; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Dedoussis GV; Department of Dietetics-Nutrition, Harokopio University, Athens, Greece., Bornstein SR; Department of Medicine, Division for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Schwarz PEH; Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Tönjes A; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Winkelmann BR; Cardiology Group, Frankfurt-Sachsenhausen, Germany., Boehm BO; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore and Imperial College London, Singapore, Singapore., März W; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany., Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Price JF; Usher Institute, University of Edinburgh, Edinburgh, UK., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Wellcome Trust Sanger Institute, Hinxton, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD, King Abdulaziz University, Jeddah, Saudi Arabia., Körner A; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.; Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Lakka TA; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland., Keinanen-Kiukaanniemi SM; Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland.; Unit of General Practice, Oulu University Hospital, Oulu, Finland., Saaristo TE; Finnish Diabetes Association, Tampere, Finland.; Pirkanmaa Hospital District, Tampere, Finland., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Tuomilehto J; Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Centre for Vascular Prevention, Danube-University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Männistö S; Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.; Department of Public Health & Clinical Medicine, Units of Medicine and Nutritional Research, Umeå University, Umeå, Sweden., Hayward C; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Vitart V; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK., Kaprio J; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Visvikis-Siest S; Université de Lorraine, IGE-PCV, F-54000, Nancy, France., Balkau B; Inserm, CESP Center for Research in Epidemiology and Public Health, U1018, Villejuif, France.; Univ Paris-Saclay, Univ Paris Sud, UVSQ, UMRS 1018, UMRS 1018, Villejuif, France., Altshuler D; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Rudan I; Usher Institute, University of Edinburgh, Edinburgh, UK., Stumvoll M; Department of Medicine, University of Leipzig, Leipzig, Germany.; IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany., Campbell H; Usher Institute, University of Edinburgh, Edinburgh, UK., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Centre for Medical Systems Biology, Leiden, the Netherlands., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD, München-Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Illig T; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.; Institute of Human Genetics, Hannover Medical School, Hannover, Germany., Ferrucci L; Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Pramstaller PP; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy.; Department of Neurology, General Central Hospital, Bolzano, Italy.; Department of Neurology, University of Lübeck, Lübeck, Germany., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Frayling TM; Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, UK., Shuldiner AR; Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA.; The Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Palmer LJ; School of Public Health, University of Adelaide, Adelaide, Australia., Penninx BW; Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands., Meneton P; U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006, Paris, France., Harris TB; Geriatric Epidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA., Navis G; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Harst PV; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Smith GD; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., Loos RJF; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Salomaa V; Finnish Institute for Health and Welfare, Helsinki, Finland., Soranzo N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Boomsma DI; Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands., Groop L; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden., Tuomi T; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.; Endocrinology, Abdominal Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Program for Clinical and Molecular Metabolism, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland., Hofman A; Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands.; Netherlands Consortium for healthy ageing, the Hague, the Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine University of Iceland, Reykjavik, Iceland., Siscovick DS; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Lecoeur C; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France., Vollenweider P; Department of Medicine, University Hospital Lausanne, Lausanne, Switzerland., Franco-Cereceda A; Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Eriksson P; Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden., Jarvelin MR; Department of Epidemiology and Biostatistics and HPA-MRC Center, School of Public Health, Imperial College London, London, UK.; Institue of Health Sciences, University of Oulu, Oulu, Finland., Stefansson K; deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; Department of Cardiology, Karolinska University Hospital Solna, Stockholm, Sweden., Nicholson G; Department of Statistics, University of Oxford, Oxford, UK., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK., Dermitzakis ET; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland., Lindgren CM; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK.; Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA., Froguel P; University of Lille Nord de France, Lille, France.; CNRS UMR8199, Institut Pasteur de Lille, Lille, France.; Department of Medicine, Imperial College London, London, UK., Kaakinen MA; Department of Medicine, Imperial College London, London, UK.; School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.; Department of Clinical Science, University of Bergen, Bergen, Norway., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.; Department of Physiology & Neuroscience, Keck School of Medicine of USC, Los Angeles, CA, USA.; USC Diabetes and Obesity Research Institute, Los Angeles, CA, USA., Ingelsson E; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, 94305, USA., Florez JC; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Barroso I; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.; University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.; Exeter Centre of ExcEllence in Diabetes (ExCEED), University of Exeter Medical School, Exeter, UK., Morris AP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK., Prokopenko I; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. i.prokopenko@surrey.ac.uk.; Department of Medicine, Imperial College London, London, UK. i.prokopenko@surrey.ac.uk.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. i.prokopenko@surrey.ac.uk.; School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; Institute of Biochemistry and Genetics, Ufa Federal Research Centre Russian Academy of Sciences, Ufa, Russian Federation. i.prokopenko@surrey.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2021 Jan 05; Vol. 12 (1), pp. 24. Date of Electronic Publication: 2021 Jan 05.