Disruption of a 35 KB enhancer impairs CTCF binding and MLH1 expression in colorectal cells

Autor: Liu, Q, Thoms, JAI, Nunez, AC, Huang, Y, Knezevic, K, Packham, D, Poulos, RC, Williams, R, Beck, D, Hawkins, NJ, Ward, RL, Wong, JWH, Hesson, LB, Sloane, MA, Pimanda, JE

© 2018 American Association for Cancer Research. Purpose: MLH1 is a major tumor suppressor gene involved in the pathogenesis of Lynch syndrome and various sporadic cancers. Despite their potential pathogenic importance, genomic regions capable of re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::7b2c35a822a91dcd3db42a49203877aa
https://hdl.handle.net/10453/131406

Proteomic-based stratification of intermediate-risk prostate cancer patients.

Autor: Zhong Q; https://ror.org/01bsaey45 ProCan, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Sun R; https://ror.org/05hfa4n20 iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China., Aref AT; https://ror.org/01bsaey45 ProCan, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Noor Z; https://ror.org/01bsaey45 ProCan, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Anees A; https://ror.org/01bsaey45 ProCan, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Zhu Y; https://ror.org/05hfa4n20 iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China., Lucas N; https://ror.org/01bsaey45 ProCan, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Poulos RC; https://ror.org/01bsaey45 ProCan, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Lyu M; https://ror.org/05hfa4n20 iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China., Zhu T; https://ror.org/05hfa4n20 iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China., Chen GB; Urology & Nephrology Center, Department of Urology, Clinical Research Institute, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China., Wang Y; https://ror.org/05hfa4n20 iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China., Ding X; https://ror.org/05hfa4n20 iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China., Rutishauser D; Department of Pathology and Molecular Pathology, University Hospital Zürich, Zürich, Switzerland., Rupp NJ; Department of Pathology and Molecular Pathology, University Hospital Zürich, Zürich, Switzerland., Rueschoff JH; Department of Pathology and Molecular Pathology, University Hospital Zürich, Zürich, Switzerland., Poyet C; Department of Urology, University Hospital Zürich, Zürich, Switzerland., Hermanns T; Department of Urology, University Hospital Zürich, Zürich, Switzerland., Fankhauser C; Department of Urology, University Hospital Zürich, Zürich, Switzerland.; Department of Urology, Cantonal Hospital Lucerne, Lucerne, Switzerland., Rodríguez Martínez M; IBM Zürich Research Laboratory, Zürich, Switzerland., Shao W; State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China., Buljan M; Empa - Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Neumann JF; CECAD, University of Cologne, Cologne, Germany., Beyer A; CECAD, University of Cologne, Cologne, Germany., Hains PG; https://ror.org/01bsaey45 ProCan, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Reddel RR; https://ror.org/01bsaey45 ProCan, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Robinson PJ; https://ror.org/01bsaey45 ProCan, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia., Aebersold R; Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland aebersold@imsb.biol.ethz.ch.; Faculty of Science, University of Zürich, Zürich, Switzerland., Guo T; https://ror.org/05hfa4n20 iMarker Lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China guotiannan@westlake.edu.cn.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China., Wild PJ; Goethe University Frankfurt, Dr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt am Main, Germany peter.wild@ukffm.de.; Frankfurt Institute for Advanced Studies, Frankfurt am Main, Germany.

Publikováno v: Life science alliance [Life Sci Alliance] 2023 Dec 04; Vol. 7 (2). Date of Electronic Publication: 2023 Dec 04 (Print Publication: 2024).

Pan-cancer proteomic map of 949 human cell lines.

Autor: Gonçalves E; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK; Instituto Superior Técnico (IST), Universidade de Lisboa, 1049-001 Lisboa, Portugal; INESC-ID, 1000-029 Lisboa, Portugal., Poulos RC; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Cai Z; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Barthorpe S; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Manda SS; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Lucas N; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Beck A; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Bucio-Noble D; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Dausmann M; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Hall C; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Hecker M; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Koh J; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Lightfoot H; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Mahboob S; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Mali I; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Morris J; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Richardson L; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Seneviratne AJ; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Shepherd R; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Sykes E; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Thomas F; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Valentini S; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Williams SG; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Wu Y; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Xavier D; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., MacKenzie KL; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Hains PG; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Tully B; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Robinson PJ; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia. Electronic address: probinson@cmri.org.au., Zhong Q; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia. Electronic address: qzhong@cmri.org.au., Garnett MJ; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK. Electronic address: mg12@sanger.ac.uk., Reddel RR; ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia. Electronic address: rreddel@cmri.org.au.

Publikováno v: Cancer cell [Cancer Cell] 2022 Aug 08; Vol. 40 (8), pp. 835-849.e8. Date of Electronic Publication: 2022 Jul 14.

Role of POT1 in Human Cancer.

Autor: Wu Y; Cancer Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead NSW 2145, Australia.; ProCan® Cancer Data Science Group, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead NSW 2145, Australia., Poulos RC; ProCan® Cancer Data Science Group, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead NSW 2145, Australia., Reddel RR; Cancer Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead NSW 2145, Australia.

Publikováno v: Cancers [Cancers (Basel)] 2020 Sep 24; Vol. 12 (10). Date of Electronic Publication: 2020 Sep 24.

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.

Autor: Fang H; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region., Barbour JA; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.; Prince of Wales Clinical School, UNSW Medicine, UNSW Sydney, New South Wales, Australia., Poulos RC; Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales, Australia., Katainen R; Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland., Aaltonen LA; Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland., Wong JWH; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region.; Prince of Wales Clinical School, UNSW Medicine, UNSW Sydney, New South Wales, Australia.

Publikováno v: PLoS genetics [PLoS Genet] 2020 Feb 03; Vol. 16 (2), pp. e1008572. Date of Electronic Publication: 2020 Feb 03 (Print Publication: 2020).