Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Pottayil G. Sasikumar"'
Autor:
Pottayil G. Sasikumar, Naremaddepalli S. Sudarshan, Srinivas Adurthi, Raghuveer K. Ramachandra, Dodderi S. Samiulla, Anirudha Lakshminarasimhan, Anuradha Ramanathan, Talapaneni Chandrasekhar, Amit A. Dhudashiya, Sumalatha R. Talapati, Nagesh Gowda, Sreenivasulareddy Palakolanu, Jiju Mani, Bandi Srinivasrao, David Joseph, Nigam Kumar, Rashmi Nair, Hanudatta S. Atreya, Nagaraj Gowda, Murali Ramachandra
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Sasikumar et al. describe the identification and characterization of CA-170, a small molecule inhibitor of PD-L1 and VISTA. They find that CA-170 activates T cells and exhibits anti-tumor efficacy in mouse models. This study highlights the potential
Externí odkaz:
https://doaj.org/article/0dc6fdd12b8e4be4a3c38267bc1cd96a
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Pioneering success of antibodies targeting immune checkpoints such as programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) has changed the outlook of cancer therapy. Although these antibodies show impressive
Externí odkaz:
https://doaj.org/article/43290f1c17fa41c2b710e85435b393de
Publikováno v:
Medicine in Drug Discovery, Vol 8, Iss , Pp 100073- (2020)
Immune system regained the attention of oncologists and has entered the mainstream for cancer therapy since the discovery of checkpoint antibodies targeting CTLA4 and PD-1 pathways. Efficacy in only a subset of patient population observed with the cu
Externí odkaz:
https://doaj.org/article/d6fc7ac6a2cd4981ab98b44eaf5a5b50
Autor:
Murali Ramachandra, Nagaraj Gowda, Rajeev Shrimali, Rashmi Nair, Krishnaprasad Subbarao, Dodderi S. Samiulla, Leena K. Satyam, Sriharibabu Vunnum, Koteswararao Vemula, Sureshkumar Vadlamani, Amit A. Dhudashiya, Srinivas Adurthi, Raghuveer K. Ramachandra, Pottayil G. Sasikumar
Supplementary Figure 4 NP-12 increased the levels of IFN-γ in the Cytomegalovirus (CMV) antigen recall assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f336a0d776ab2021945b16a73c13a5
https://doi.org/10.1158/1535-7163.22507132.v1
https://doi.org/10.1158/1535-7163.22507132.v1
Autor:
Murali Ramachandra, Nagaraj Gowda, Rajeev Shrimali, Rashmi Nair, Krishnaprasad Subbarao, Dodderi S. Samiulla, Leena K. Satyam, Sriharibabu Vunnum, Koteswararao Vemula, Sureshkumar Vadlamani, Amit A. Dhudashiya, Srinivas Adurthi, Raghuveer K. Ramachandra, Pottayil G. Sasikumar
Pioneering success of antibodies targeting immune checkpoints such as PD-1 and CTLA4 has opened novel avenues for cancer immunotherapy. Along with impressive clinical activity, severe immune-related adverse events (irAE) due to the breaking of immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ad2db042b93c6b3c763aed681446fd6
https://doi.org/10.1158/1535-7163.c.6538594.v1
https://doi.org/10.1158/1535-7163.c.6538594.v1
Autor:
Murali Ramachandra, Nagaraj Gowda, Rajeev Shrimali, Rashmi Nair, Krishnaprasad Subbarao, Dodderi S. Samiulla, Leena K. Satyam, Sriharibabu Vunnum, Koteswararao Vemula, Sureshkumar Vadlamani, Amit A. Dhudashiya, Srinivas Adurthi, Raghuveer K. Ramachandra, Pottayil G. Sasikumar
Table 1A: Rescue of proliferation and IFN- γ release in the presence of PD-L1 or PD-L2 in mouse splenocytes Table 1B: Rescue of proliferation and IFN- γ release in the presence of PD-L1 or PD-L2 in human PBMCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd4be2bc78829d994ee52370872fe47
https://doi.org/10.1158/1535-7163.22507123
https://doi.org/10.1158/1535-7163.22507123
Autor:
Murali Ramachandra, Nagaraj Gowda, Rajeev Shrimali, Rashmi Nair, Krishnaprasad Subbarao, Dodderi S. Samiulla, Leena K. Satyam, Sriharibabu Vunnum, Koteswararao Vemula, Sureshkumar Vadlamani, Amit A. Dhudashiya, Srinivas Adurthi, Raghuveer K. Ramachandra, Pottayil G. Sasikumar
Supplementary Figure 5 Pharmacokinetic profile of NP-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720227fc13f6b6c01e7a6b80ad55dbfe
https://doi.org/10.1158/1535-7163.22507129.v1
https://doi.org/10.1158/1535-7163.22507129.v1
Autor:
Murali Ramachandra, Nagaraj Gowda, Rajeev Shrimali, Rashmi Nair, Krishnaprasad Subbarao, Dodderi S. Samiulla, Leena K. Satyam, Sriharibabu Vunnum, Koteswararao Vemula, Sureshkumar Vadlamani, Amit A. Dhudashiya, Srinivas Adurthi, Raghuveer K. Ramachandra, Pottayil G. Sasikumar
Supplementary Figure 3 NP-12 increased the levels of IFN-γ in the Tetanus toxoid recall assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086377a3521ed9ce53dd610b12f7f4bd
https://doi.org/10.1158/1535-7163.22507138
https://doi.org/10.1158/1535-7163.22507138
Autor:
Murali Ramachandra, Nagaraj Gowda, Rajeev Shrimali, Rashmi Nair, Krishnaprasad Subbarao, Dodderi S. Samiulla, Leena K. Satyam, Sriharibabu Vunnum, Koteswararao Vemula, Sureshkumar Vadlamani, Amit A. Dhudashiya, Srinivas Adurthi, Raghuveer K. Ramachandra, Pottayil G. Sasikumar
Supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3566ff32a6427066d04b2e81da082ee
https://doi.org/10.1158/1535-7163.22507126.v1
https://doi.org/10.1158/1535-7163.22507126.v1
Autor:
Murali Ramachandra, Nagaraj Gowda, Rajeev Shrimali, Rashmi Nair, Krishnaprasad Subbarao, Dodderi S. Samiulla, Leena K. Satyam, Sriharibabu Vunnum, Koteswararao Vemula, Sureshkumar Vadlamani, Amit A. Dhudashiya, Srinivas Adurthi, Raghuveer K. Ramachandra, Pottayil G. Sasikumar
Supplementary Figure 1 NP-12 labeled with FITC shows higher binding to CHOK1 cells overexpressing PD-L1 as compared to WT CHOK1 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6285686faaa504f871c7996d25a03b49
https://doi.org/10.1158/1535-7163.22507144
https://doi.org/10.1158/1535-7163.22507144