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Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation.

Autor: Le Floc'h A; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Allinne J; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Nagashima K; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Scott G; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Birchard D; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Asrat S; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Bai Y; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Lim WK; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Martin J; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Huang T; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Potocky TB; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Kim JH; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Rafique A; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Papadopoulos NJ; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Stahl N; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Yancopoulos GD; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Murphy AJ; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Sleeman MA; Regeneron Pharmaceuticals, Tarrytown, NY, USA., Orengo JM; Regeneron Pharmaceuticals, Tarrytown, NY, USA.

Publikováno v: Allergy [Allergy] 2020 May; Vol. 75 (5), pp. 1188-1204. Date of Electronic Publication: 2020 Jan 03.

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Akademický článek

A Biparatopic Antibody That Modulates MET Trafficking Exhibits Enhanced Efficacy Compared with Parental Antibodies in MET-Driven Tumor Models.

Autor: DaSilva JO; Regeneron Pharmaceuticals, Inc., Tarrytown, New York. john.dasilva@regeneron.com., Yang K; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Perez Bay AE; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Andreev J; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Ngoi P; UC Santa Cruz, Program for Biomedical Sciences and Engineering, Santa Cruz, California., Pyles E; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Franklin MC; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Dudgeon D; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Rafique A; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Dore A; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Delfino FJ; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Potocky TB; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Babb R; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Chen G; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., MacDonald D; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Olson WC; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Thurston G; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Daly C; Regeneron Pharmaceuticals, Inc., Tarrytown, New York.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2020 Mar 15; Vol. 26 (6), pp. 1408-1419. Date of Electronic Publication: 2019 Dec 17.

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Akademický článek

A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells.

Autor: Cruz JW; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Damko E; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Modi B; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Tu N; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Meagher K; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Voronina V; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Gartner H; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Ehrlich G; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Rafique A; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Babb R; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Aneja P; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Potocky TB; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., D' Orvilliers A; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Coppi A; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., E SY; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Qiu H; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Williams CM; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Bennett BL; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Chen G; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Macdonald L; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Olson W; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Lin JC; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Stahl N; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Murphy AJ; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Kyratsous CA; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA., Prasad BC; Regeneron Pharmaceuticals Inc., Tarrytown, NY, 10591, USA. brinda.prasad@regeneron.com.

Publikováno v: Scientific reports [Sci Rep] 2019 Aug 19; Vol. 9 (1), pp. 12031. Date of Electronic Publication: 2019 Aug 19.

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Akademický článek

Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers.

Autor: Kelly MP; Regeneron Pharmaceuticals, Inc., Tarrytown, New York. marcus.kelly@regeneron.com., Hickey C; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Makonnen S; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Coetzee S; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Jalal S; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Wang Y; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Delfino F; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Shan J; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Potocky TB; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Chatterjee I; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Andreev J; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Kunz A; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., D'Souza C; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Giurleo JT; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Nittoli T; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Trail PA; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Thurston G; Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Kirshner JR; Regeneron Pharmaceuticals, Inc., Tarrytown, New York.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2017 Jul; Vol. 16 (7), pp. 1299-1311. Date of Electronic Publication: 2017 Apr 04.

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Akademický článek

Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice.

Autor: Latres E; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Pangilinan J; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Miloscio L; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Bauerlein R; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Na E; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Potocky TB; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Huang Y; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Eckersdorff M; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Rafique A; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Mastaitis J; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Lin C; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Murphy AJ; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Yancopoulos GD; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Gromada J; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA., Stitt T; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 USA.

Publikováno v: Skeletal muscle [Skelet Muscle] 2015 Oct 09; Vol. 5, pp. 34. Date of Electronic Publication: 2015 Oct 09 (Print Publication: 2015).

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Akademický článek

ERBB3/HER2 signaling promotes resistance to EGFR blockade in head and neck and colorectal cancer models.

Autor: Zhang L; Authors' Affiliation: Regeneron Pharmaceuticals, Inc., Tarrytown, New York., Castanaro C, Luan B, Yang K, Fan L, Fairhurst JL, Rafique A, Potocky TB, Shan J, Delfino FJ, Shi E, Huang T, Martin JH, Chen G, Macdonald D, Rudge JS, Thurston G, Daly C

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2014 May; Vol. 13 (5), pp. 1345-55. Date of Electronic Publication: 2014 Mar 14.

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