Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Potnick, Justin"'
Autor:
Qiu, Hui, Ali, Zahid, Bender, Andrew, Caldwell, Richard, Chen, Yi-Ying, Fang, Zhizhou, Gardberg, Anna, Glaser, Nina, Goettsche, Anja, Goutopoulos, Andreas, Grenningloh, Roland, Hanschke, Bettina, Head, Jared, Johnson, Theresa, Jones, Christopher, Jones, Reinaldo, Kulkarni, Shashank, Maurer, Christine, Morandi, Federica, Neagu, Constantin, Poetzsch, Sven, Potnick, Justin, Schmidt, Ralf, Roe, Katherine, Viacava Follis, Ariele, Wing, Carolyn, Zhu, Xiaohua, Sherer, Brian
Publikováno v:
In Bioorganic & Medicinal Chemistry 15 June 2021 40
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Brian H. Heasley, Jing Lin, Thomas F. N. Haxell, Igor Mochalkin, Constantin Neagu, Felix Rohdich, Ruoxi Lan, Amanda E. Sutton, Jennifer Jackson, Potnick Justin, Bayard R. Huck, Andreas Machl, Katrin Georgi, Xiaoling Chen, Sherer Brian A, Erik Wilker, Thomas E. Richardson, Anderson Clark, Reinaldo Jones, Johnson Theresa L, Lizbeth Celeste Deselm, Andreas Goutopoulos, Hui Tian, Yufang Xiao, Joseph A. Moore, Lindsey Crowley
Publikováno v:
Journal of Medicinal Chemistry. 64:14603-14619
Herein, we report the discovery of a novel class of quinazoline carboxamides as dual p70S6k/Akt inhibitors for the treatment of tumors driven by alterations to the PI3K/Akt/mTOR (PAM) pathway. Through the screening of in-house proprietary kinase libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0f668e1b7d0d3fdf120a40211a6894
https://doi.org/10.1021/acs.jmedchem.1c01087
https://doi.org/10.1021/acs.jmedchem.1c01087
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Andrew Bender, Anna Gardberg, Lesley Liu-Bujalski, Jared Head, Igor Mochalkin, Potnick Justin, Johnson Theresa L, Federica Morandi, Roland Grenningloh, Richard D. Caldwell, Reinaldo Jones, Ariele Viacava Follis, Hui Qiu, Andreas Goutopoulos, Daigen Xu, Sherer Brian A
Publikováno v:
ChemMedChem. 14:217-223
Bruton's tyrosine kinase (Btk) is an attractive target for the treatment of a wide array of B-cell malignancies and autoimmune diseases. Small-molecule covalent irreversible Btk inhibitors targeting Cys481 have been developed for the treatment of suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f5fa08a314bbf9e58760306ecdf58d
https://doi.org/10.1002/cmdc.201800714
https://doi.org/10.1002/cmdc.201800714
Autor:
Xiao, Yufang, Karra, Srinivasa, Goutopoulos, Andreas, Morse, Noune Tahmassian, Zhang, Susan, Dhanabal, Mohanraj, Tian, Hui, Seenisamy, Jeyaprakashnarayanan, Jayadevan, Jayashankaran, Caldwell, Richard, Potnick, Justin, Bleich, Matthew, Chekler, Eugene, Sherer, Brian, Sriraman, Venkataraman
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 July 2019 29(13):1660-1664
Autor:
Anna Gardberg, Federica Morandi, Katherine Roe, Carolyn Wing, Andreas Goutopoulos, Richard D. Caldwell, Johnson Theresa L, Yi-Ying Chen, Constantin Neagu, Shashank Kulkarni, Ralf Schmidt, Roland Grenningloh, Sherer Brian A, Sven Poetzsch, Andrew Bender, Anja Goettsche, Nina Glaser, Christopher Charles Victor Jones, Xiaohua Zhu, Zahid Ali, Jared Head, Zhizhou Fang, Christine Maurer, Ariele Viacava Follis, Potnick Justin, Reinaldo Jones, Hui Qiu, Bettina Hanschke
Publikováno v:
Bioorganic & Medicinal Chemistry. 40:116163
Bruton’s tyrosine kinase (BTK) is a cytoplasmic, non-receptor tyrosine kinase member of the TEC family of tyrosine kinases. Pre-clinical and clinical data have shown that targeting BTK can be used for the treatment for B-cell disorders. Here we dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103ce6c76a17a7f47605d995d247a29b
https://doi.org/10.1016/j.bmc.2021.116163
https://doi.org/10.1016/j.bmc.2021.116163
Autor:
Hui Tian, Richard D. Caldwell, Jayadevan Jayashankaran, Andreas Goutopoulos, Srinivasa R. Karra, Sherer Brian A, Matthew Bleich, Susan Zhang, Jeyaprakashnarayanan Seenisamy, Noune Tahmassian Morse, Potnick Justin, Chekler Eugene, Mohanraj Dhanabal, Yufang Xiao, Venkataraman Sriraman
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(13)
The P2X7 receptor (P2X7R) plays an important role in diverse conditions associated with tissue damage and inflammation, suggesting that the human P2X7R (hP2X7R) is an attractive therapeutic target. In the present study, the synthesis and structure-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89f7c92fca5fbd2462d086687cb4644
https://pubmed.ncbi.nlm.nih.gov/31031055
https://pubmed.ncbi.nlm.nih.gov/31031055
Autor:
Qiu, Hui, Liu-Bujalski, Lesley, Caldwell, Richard D., Viacava Follis, Ariele, Gardberg, Anna, Goutopoulos, Andreas, Grenningloh, Roland, Head, Jared, Johnson, Theresa, Jones, Christopher C.V., Jones, Reinaldo, Mochalkin, Igor, Morandi, Federica, Neagu, Constantin, Potnick, Justin, Sherer, Brian
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 November 2018 28(20):3307-3311
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.