Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses

Autor: Zhou, Qifan, Luo, Yinzhu, Zhu, Yujun, Chen, Qishu, Qiu, Jingfei, Cong, Feng, Li, Yingjun, Zhang, Xumu

Publikováno v: In European Journal of Medicinal Chemistry 5 March 2023 249

Potent in vivo efficacy of oral gallium maltolate in treatment-resistant glioblastoma

Autor: Mona M. Al-Gizawiy, Robert T. Wujek, Hisham S. Alhajala, Jonathan M. Cobb, Melissa A. Prah, Ninh B. Doan, Jennifer M. Connelly, Christopher R. Chitambar, Kathleen M. Schmainda

Publikováno v: Frontiers in Oncology, Vol 13 (2024)

BackgroundTreatment-resistant glioblastoma (trGBM) is an aggressive brain tumor with a dismal prognosis, underscoring the need for better treatment options. Emerging data indicate that trGBM iron metabolism is an attractive therapeutic target. The no

Externí odkaz: https://doaj.org/article/2a555886013f4c458fa6a633cc888fe1

Potent in vivo efficacy of oral gallium maltolate in treatment-resistant glioblastoma.

Autor: Al-Gizawiy MM; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States., Wujek RT; Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, United States., Alhajala HS; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States., Cobb JM; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States., Prah MA; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States., Doan NB; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States., Connelly JM; Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, United States., Chitambar CR; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States., Schmainda KM; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States.; Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, United States.

Publikováno v: Frontiers in oncology [Front Oncol] 2024 Jan 15; Vol. 13, pp. 1278157. Date of Electronic Publication: 2024 Jan 15 (Print Publication: 2023).

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