Zobrazeno 1 - 10
of 488
pro vyhledávání: '"Potency assay"'
Autor:
Frederic St‐Denis‐Bissonnette, Shirley Qiu, Sarah E. Cummings, Melanie Kirkby, Yohannes Haile, Sarah Wassmer, Gauri Muradia, Jelica Mehic, Andrew Stalker, Amit Shrestha, Michele Ardolino, Seung‐Hwan Lee, Dylan Burger, Lisheng Wang, Jessie R. Lavoie
Publikováno v:
Journal of Extracellular Biology, Vol 3, Iss 7, Pp n/a-n/a (2024)
Abstract Natural killer cell‐derived extracellular vesicles (NK‐EVs) are candidate biotherapeutics against various cancers. However, standardised potency assays are necessary for a reliable assessment of NK‐EVs' cytotoxicity. This study aims to
Externí odkaz:
https://doaj.org/article/e9c74a4ae6444282ad687844f70ffab3
Autor:
Dengyun Sun, Brian K. Meyer, Dhanvanthri S. Deevi, Asra Mirza, Li He, Ashley Gruber, Susan J. Abbondanzo, Noah A. Benton, Melissa C. Whiteman, Robert C. Capen, Kevin B. Gurney
Publikováno v:
Vaccines, Vol 12, Iss 7, p 769 (2024)
The rapid development of potency assays is critical in the development of life-saving vaccines. The traditional plaque assay or fifty percent tissue culture infectious dose (TCID50) assay used to measure the potency of live virus vaccines is time con
Externí odkaz:
https://doaj.org/article/cd06f6bd0d944865bcbf6cbeb46dc9dd
Publikováno v:
SLAS Discovery, Vol 28, Iss 1, Pp 29-38 (2023)
For process optimisation Design of Experiments (DoE) has long been established as a more powerful strategy than a One Factor at a Time approach. Nevertheless, DoE is not widely used especially in the field of cell-based bioassay development although
Externí odkaz:
https://doaj.org/article/fb4a0a035ab9401cb357ba99f24ea9f7
Autor:
Rosa Bartolomeo, Fulvia Troise, Simona Allocca, Giulia Sdruscia, Rosa Vitale, Veronica Bignone, Anna Maria Petrone, Giuseppina Romano, Anna Morena D’Alise, Valentino Ruzza, Irene Garzia, Guido Leoni, Rossella Merone, Francesca Lanzaro, Stefano Colloca, Loredana Siani, Elisa Scarselli, Gabriella Cotugno
Publikováno v:
Vaccines, Vol 12, Iss 3, p 325 (2024)
Quality control testing of vaccines, including potency assessment, is critical to ensure equivalence of clinical lots. We developed a potency assay to support the clinical advancement of Nous-209, a cancer vaccine based on heterologous prime/boost ad
Externí odkaz:
https://doaj.org/article/43d45046ce34472eb9d0812940b77c00
Akademický článek
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Autor:
E. I. Komarovskaya, O. V. Perelygyna
Publikováno v:
Эпидемиология и вакцинопрофилактика, Vol 21, Iss 3, Pp 96-106 (2022)
Relevance. Diphtheria toxoid (DT) and tetanus toxoid (TT) manufacturing appears as many steps process. On every stage of proceeding vaccine the control of critical points is being provided. The Parke Williams 8 strain of Corynebacterium diphtheriae u
Externí odkaz:
https://doaj.org/article/e9635138c211454caa1cde10460b1746
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Potency testing and release of annual influenza vaccines require preparation, calibration, and distribution of reference antigens (RAs) and antisera every year, which takes an average of 8 to 12 weeks, and can be a major limiting factor in pandemic s
Externí odkaz:
https://doaj.org/article/fceb0a2b3d9d48a58ab335f0f3ee3faf
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2022)
Abstract In pre-clinical studies, human adipose-derived stem cells (hASCs) have shown great promise as a treatment modality for healing of cutaneous wounds. The advantages of hASCs are that they are relatively easy to obtain in large numbers from bas
Externí odkaz:
https://doaj.org/article/ddaf095d90004667b2003ce6e9f191d6
Autor:
Marine Geoffroy, Louna Pili, Valentina Buffa, Maëlle Caroff, Anne Bigot, Evelyne Gicquel, Grégory Rouby, Isabelle Richard, Romain Fragnoud
Publikováno v:
Cells, Vol 12, Iss 20, p 2444 (2023)
Limb-Girdle Muscular Dystrophy R9 (LGMDR9) is a dystroglycanopathy caused by Fukutin-related protein (FKRP) defects leading to the deficiency of α-DG glycosylation, essential to membrane integrity. Recombinant adeno-associated viral vector (rAAV) ge
Externí odkaz:
https://doaj.org/article/2adc7642487e43eab2c01182c7f5af74
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe current compendial assay for haemagglutinin antigen potency in influenza vaccine is the single radial immunodiffusion (SRID) which is time consuming and can lead to delays in release of vaccine. We previously described an alternate capt
Externí odkaz:
https://doaj.org/article/1a0572515e6649cea2f04fd159afccd6