Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Potassium Channel Binding"'
Autor:
Mangesh I. Chaudhari, Susan B. Rempe
Ion hydration structure and free energy establish criteria for understanding selective ion binding in potassium K+ ion channels, and may be significant to understanding blocking mechanisms as well. Recently, we investigated the hydration properties o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae4e0e36272f069fa9e2b3fd3d54bcd
http://arxiv.org/abs/1801.08078
http://arxiv.org/abs/1801.08078
Autor:
Richard W. Friesen, Yves Ducharme, Richard G. Ball, Marc Blouin, Louise Boulet, Bernard Côté, Richard Frenette, Mario Girard, Daniel Guay, Zheng Huang, Thomas R. Jones, France Laliberté, Joseph J. Lynch, Joseph Mancini, Evelyn Martins, Paul Masson, Eric Muise, Douglas J. Pon, Peter K. S. Siegl, Angela Styhler, Nancy N. Tsou, Mervyn J. Turner, Robert N. Young, Yves Girard
Publikováno v:
Journal of Medicinal Chemistry. 46:2413-2426
A SAR study on the tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors related to 1 is described. In addition to inhibitory potency against PDE4 and the lipopolysaccharide-induced production of TNFalpha in human whole blood, the binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18495e1aec7ef1822aab54c123463878
https://doi.org/10.1021/jm0204542
https://doi.org/10.1021/jm0204542
Publikováno v:
Biopolymers. 58:422-436
ShK toxin, a 35-residue polypeptide cross-linked by three disulfides, is a potent blocker of voltage-gated potassium channels and is of interest as a lead in the development of new immunosuppressant agents. ShK toxin contains two short stretches of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::663aba75e1b0e514612d1d8bd0ae79ed
https://doi.org/10.1002/1097-0282(20010405)58:4<422::aid-bip1018>3.0.co
https://doi.org/10.1002/1097-0282(20010405)58:4<422::aid-bip1018>3.0.co
Autor:
Heiko Rauer, K. Kalman, Kathy Paschetto, Angela Nguyen, Edward P. Christian, Michael D. Cahalan, George A. Gutman, William R. Kem, Raymond S. Norton, Michael W. Pennington, V.M. Mahnir, K. George Chandy, Mark D. Lanigan, Stephan Grissmer
Publikováno v:
Journal of Biological Chemistry. 273:32697-32707
The voltage-gated potassium channel in T lymphocytes, Kv1.3, is an important molecular target for immunosuppressive agents. A structurally defined polypeptide, ShK, from the sea anemone Stichodactyla helianthus inhibited Kv1.3 potently and also block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7b612592cdc394456df7f7fedca46b
https://doi.org/10.1074/jbc.273.49.32697
https://doi.org/10.1074/jbc.273.49.32697
In Vivo Role of a Potassium Channel-binding Protein in Regulating Neuronal Excitability and Behavior
Molecular details of ion channel interactions with modulatory subunits have been investigated widely in transfected cells, but the physiological roles of ion channel modulatory protein complexes in native neurons remain largely unexplored. TheDrosoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783317abdfb4a3e08722e446efd74093
https://europepmc.org/articles/PMC2785714/
https://europepmc.org/articles/PMC2785714/
Autor:
Shiho Ishikawa, Keita Nagai, Hisashi Iwaasa, Akio Kanatani, Hiroyasu Tsuge, Naoko Fujino, Makoto Ando, Akane Ishihara, Akira Gomori, Hidefumi Kitazawa, Takehiro Fukami, Aya Sakuraba, Satoshi Mashiko, Hirobumi Takahashi, Makoto Jitsuoka, Tomoyuki Ohe, Nagaaki Sato, Ryuichi Moriya
Publikováno v:
Journal of medicinal chemistry. 52(10)
A series of novel imidazoline derivatives was synthesized and evaluated as neuropeptide Y (NPY) Y5 receptor antagonists. Optimization of previously reported imidazoline leads, 1a and 1b, was attempted by introduction of substituents at the 5-position
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d955767920b9ae2d2fcddfe34d41f9d
https://pubmed.ncbi.nlm.nih.gov/19459652
https://pubmed.ncbi.nlm.nih.gov/19459652
Autor:
Victoria E.S. Scott
Publikováno v:
Current Protocols in Pharmacology
This unit provides an introduction to the binding of specific ligands to K+ channels that are expressed in a number of different preparations. The assays described can be used for screening a large number of compounds for interaction at specific bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afe10e9c4da2df3bff1e734a5f54787a
https://doi.org/10.1002/0471141755.ph0117s06
https://doi.org/10.1002/0471141755.ph0117s06
Publikováno v:
Structure (London, England : 1993). 3(10)
Background: β -bungarotoxin is a heterodimeric neurotoxin consisting of a phospholipase subunit linked by a disulfide bond to a K + channel binding subunit which is a member of the Kunitz protease inhibitor superfamily. Toxicity, characterized by bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fb715392d9b964eb3b0e2562f4ea00
https://pubmed.ncbi.nlm.nih.gov/8590005
https://pubmed.ncbi.nlm.nih.gov/8590005
Autor:
Zibold, Jutta
Im ersten Teil dieser Arbeit wurde das Bindungsverhalten der Radioliganden 3H-P1075 (Kaliumkanalöffner) und 3H-Glibenclamid (3H-GBC, Kanalschliesser) an Membranen von A10- Zellen (glatte Muskelzellen aus der embryonalen Rattenaorta) als Modell des v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______707::c8003355eb3978585eddd183d9bdbda2
https://hdl.handle.net/10900/44252
https://hdl.handle.net/10900/44252