Zobrazeno 1 - 10
of 9 655
pro vyhledávání: '"Posttranslational modification"'
Autor:
Miles R. Bryan III, Xu Tian, Jui-Heng Tseng, Baggio A. Evangelista, Joey V. Ragusa, Audra F. Bryan, Winifred Trotman, David Irwin, Todd J. Cohen
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Tauopathies, including Alzheimer’s disease (AD), are a class of neurodegenerative diseases characterized by the presence of insoluble tau inclusions. Tau phosphorylation has traditionally been viewed as the dominant post-translational modi
Externí odkaz:
https://doaj.org/article/a224761b89a941c684570125212d6515
Autor:
Jacqueline S. Womersley, Clémence Obellianne, Audrey E. Padula, Marcelo F. Lopez, William C. Griffin, Lauren E. Ball, Stefano Berto, Kathleen A. Grant, Danyelle M. Townsend, Joachim D. Uys, Patrick J. Mulholland
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117514- (2024)
Alcohol use disorder (AUD) is the most prevalent substance use disorder but there is incomplete knowledge of the underlying molecular etiology. Here, we examined the cytosolic proteome from the nucleus accumbens core (NAcC) of ethanol drinking rhesus
Externí odkaz:
https://doaj.org/article/065fd24f7c074ee98ae105b126d2ddbc
Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies
Publikováno v:
MedComm, Vol 5, Iss 10, Pp n/a-n/a (2024)
Abstract Metabolism‐related diseases, including diabetes mellitus, obesity, hyperlipidemia, and nonalcoholic fatty liver disease, are becoming increasingly prevalent, thereby posing significant threats to human health and longevity. Proteins, as th
Externí odkaz:
https://doaj.org/article/90e0205872004ea5981e3c48d60dbc8f
Autor:
Yi Qu, Nannan Gao, Shengwei Zhang, Limin Gao, Bing He, Chao Wang, Chunli Gong, Qiuyue Shi, Zhibin Li, Shiming Yang, Yufeng Xiao
Publikováno v:
MedComm, Vol 5, Iss 9, Pp n/a-n/a (2024)
Abstract N6‐methyladenosine (m6A) is the most abundant modification of RNA in eukaryotic cells. Previous studies have shown that m6A is pivotal in diverse diseases especially cancer. m6A corelates with the initiation, progression, resistance, invas
Externí odkaz:
https://doaj.org/article/49a6a16569fd4f6289a8fa5b6ca75736
Publikováno v:
mBio, Vol 15, Iss 9 (2024)
ABSTRACT Rhomboid proteases are universally conserved and facilitate the proteolysis of peptide bonds within or adjacent to cell membranes. While eukaryotic rhomboid proteases have been demonstrated to harbor unique cellular roles, prokaryotic member
Externí odkaz:
https://doaj.org/article/9367e23d2b25481eb369775c4f69f3fb
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 101060- (2024)
Protein lysine crotonylation (Kcr) is one conserved form of posttranslational modifications of proteins, which plays an important role in a series of cellular physiological and pathological processes. Lysine ε-amino groups are the primary sites of s
Externí odkaz:
https://doaj.org/article/462c88e9ef814b76a2be787331164376
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1415-1424 (2024)
Despite the tremendous progress in cancer research over the past few decades, effective therapeutic strategies are still urgently needed. Accumulating evidence suggests that immune checkpoints are the cause of tumor immune escape. PD-1/PD-L1 are amon
Externí odkaz:
https://doaj.org/article/dd287b78e26a46768b4422d5e8f7183b