Study protocol: A randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over 11 Medical and Health Sciences 1117 Public Health and Health Services 11 Medical and Health Sciences 1103 Clinical Sciences

Autor: du Puy, R. S., Postmus, I., Stott, D. J., Blum, M. R., Poortvliet, R. K. E., den Elzen, W. P. J., Peeters, R. P., van Munster, B. C., Wolffenbuttel, B. H. R., Westendorp, R. G. J., Kearney, P. M., Ford, I., Kean, S., Messow, C. M., Watt, T., Jukema, J. W., Dekkers, O. M., Smit, J. W. A., Rodondi, N., Gussekloo, J., Mooijaart, S. P.

Publikováno v: BMC endocrine disorders, 18(1):67. BioMed Central

Background: Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::702825ef79b11ba7a3c3f27f4f4ae438
https://pure.amc.nl/en/publications/study-protocol-a-randomised-controlled-trial-on-the-clinical-effects-of-levothyroxine-treatment-for-subclinical-hypothyroidism-in-people-aged-80-years-and-over-11-medical-and-health-sciences-1117-public-health-and-health-services-11-medical-and-health-sciences-1103-clinical-sciences(fd365cac-c318-4908-9887-e2bd811f9cd1).html

Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a)

Autor: Deshmukh, H.A., Colhoun, H.M., Johnson, T., McKeigue, P.M., Betteridge, D.J., Durrington, P.N., Fuller, J.H., Livingstone, S., Charlton-Menys, V., Neil, A., Poulter, N., Sever, P., Shields, D.C., Stanton, A.V., Chatterjee, A., Hyde, C., Calle, R.A., DeMicco, D.A., Trompet, S., Postmus, I., Ford, I., Jukema, J.W., Caulfield, M., Hitman, G.A., CARDS, ASCOT, PROSPER Investigators

Publikováno v: Journal of Lipid Research, Vol 53, Iss 5, Pp 1000-1011 (2012)
Journal of Lipid Research
Deshmukh, H A, Colhoun, H, Johnson, T, McKeigue, P M, Betteridge, D J, Durrington, P N, Fuller, J H, Livingstone, S, Charlton-Menys, V, Neil, A, Poulter, N, Sever, P, Shields, D C, Stanton, A V, Chatterjee, A, Hyde, C, Calle, R A, DeMicco, D A, Trompet, S, Postmus, I & Ford, I & Jukema, J W & Caulfield, M & Hitman, G A 2012, ' Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a) ', Journal of lipid research, vol. 53, no. 5, pp. 1000-1011 . https://doi.org/10.1194/jlr.P021113
Journal of Lipid Research, 53(5), 1000-1011
The Journal of Lipid Research; Vol 53
The Journal of Lipid Research

We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n = 1,156), the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT; n = 895), and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fdc804e81ef7606d6568d886be7feb
http://www.sciencedirect.com/science/article/pii/S0022227520392312

Genetic contributions to variation in general cognitive function:a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

Autor: Davies, G., Armstrong, N., Bis, J. C., Bressler, J., Chouraki, V., Giddaluru, S., Hofer, E., Ibrahim-Verbaas, C. A., Kirin, M., Lahti, J., van der Lee, S. J., Le Hellard, S., Liu, T., Marioni, R. E., Oldmeadow, C., Postmus, I., Smith, A. V., Smith, J. A., Thalamuthu, A., Thomson, R., Vitart, V., Wang, J., Yu, L., Zgaga, L., Zhao, W., Boxall, R., Harris, S. E., Hill, W. D., Liewald, D. C., Luciano, M., Adams, H., Ames, D., Amin, N., Amouyel, P., Assareh, A. A., Au, R., Becker, J. T., Beiser, A., Berr, C., Bertram, L., Boerwinkle, E., Buckley, B. M., Campbell, H., Corley, J., De Jager, P. L., Dufouil, C., Eriksson, J. G., Espeseth, T., Faul, J. D., Ford, I., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Heiss, G., Hofman, A., Holliday, E. G., Huffman, J., Kardia, S. L. R., Kochan, N., Knopman, D. S., Kwok, J. B., Lambert, J-C, Lee, T., Li, G., Li, S-C, Loitfelder, M., Lopez, O. L., Lundervold, A. J., Lundquist, Anders, Mather, K. A., Mirza, S. S., Nyberg, Lars, Oostra, B. A., Palotie, A., Papenberg, G., Pattie, A., Petrovic, K., Polasek, O., Psaty, B. M., Redmond, P., Reppermund, S., Rotter, J. I., Schmidt, H., Schuur, M., Schofield, P. W., Scott, R. J., Steen, V. M., Stott, D. J., Van Swieten, J. C., Taylor, K. D., Trollor, J., Trompet, S., Uitterlinden, A. G., Weinstein, G., Widen, E., Windham, B. G., Jukema, J. W., Wright, A. F., Wright, M. J., Yang, Q., Amieva, H., Attia, J. R., Bennett, D. A., Brodaty, H., de Craen, A. J. M., Hayward, C., Ikram, M. A., Lindenberger, U., Nilsson, Lars-Göran, Porteous, D. J., Raikkonen, K., Reinvang, I., Rudan, I., Sachdev, P. S., Schmidt, R., Schofield, P. R., Srikanth, V., Starr, J. M., Turner, S. T., Weir, D. R., Wilson, J. F., Van Duijn, C., Launer, L., Fitzpatrick, A. L., Seshadri, S., Jr, T. H. Mosley, Deary, I. J.

Publikováno v: Davies, G, Armstrong, N, Bis, J C, Bressler, J, Chouraki, V, Giddaluru, S, Hofer, E, Ibrahim-Verbaas, C A, Kirin, M, Lahti, J, van der Lee, S J, Le Hellard, S, Liu, T, Marioni, R E, Oldmeadow, C, Postmus, I, Smith, A V, Smith, J A, Thalamuthu, A, Thomson, R, Vitart, V, Wang, J, Yu, L, Zgaga, L, Zhao, W, Boxall, R, Harris, S E, Hill, W D, Liewald, D C, Luciano, M, Adams, H, Ames, D, Amin, N, Amouyel, P, Assareh, A A, Au, R, Becker, J T, Beiser, A, Berr, C, Bertram, L, Boerwinkle, E, Buckley, B M, Campbell, H, Corley, J, De Jager, P L, Dufouil, C, Eriksson, J G, Espeseth, T, Faul, J D, Ford, I, Gottesman, R F, Griswold, M E, Gudnason, V, Harris, T B, Heiss, G, Hofman, A, Holliday, E G, Huffman, J, Kardia, S L R, Kochan, N, Knopman, D S, Kwok, J B, Lambert, J-C, Lee, T, Li, G, Li, S-C, Loitfelder, M, Lopez, O L, Lundervold, A J, Lundqvist, A, Mather, K A, Mirza, S S, Nyberg, L, Oostra, B A, Palotie, A, Papenberg, G, Pattie, A, Petrovic, K, Polasek, O, Psaty, B M, Redmond, P, Reppermund, S, Rotter, J I, Schmidt, H, Schuur, M, Schofield, P W, Scott, R J, Steen, V M, Stott, D J, van Swieten, J C, Taylor, K D, Trollor, J, Trompet, S, Uitterlinden, A G, Weinstein, G, Widen, E, Windham, B G, Jukema, J W, Wright, A F, Wright, M J, Yang, Q, Amieva, H, Attia, J R, Bennett, D A, Brodaty, H, de Craen, A J M, Hayward, C, Ikram, M A, Lindenberger, U, Nilsson, L-S, Porteous, D J, Räikkönen, K, Reinvang, I, Rudan, I, Sachdev, P S, Schmidt, R, Schofield, P R, Srikanth, V, Starr, J M, Turner, S T, Weir, D R, Wilson, J F, Duijn, C V, Launer, L, Fitzpatrick, A L, Seshadri, S & Mosley Jr, T H & Deary, I J 2015, ' Genetic contributions to variation in general cognitive function : a meta-analysis of genome-wide association studies in the CHARGE consortium ( N =53 949) ', Molecular Psychiatry, vol. 20, no. 2, pp. 183-192 . https://doi.org/10.1038/mp.2014.188
Molecular Psychiatry
Molecular Psychiatry, 20(2), 183-192. Nature Publishing Group

General cognitive function is substantially heritable across the human life course from adolescence to old age. We investigated the genetic contribution to variation in this important, health- and well-being-related trait in middle-aged and older adu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b22bbcf024c4e6a96a0c9f4cb114ac34
https://www.pure.ed.ac.uk/ws/files/19374899/mp2014188a.pdf

Genetics, statins, and lipid metabolism in cardiovascular disease

Autor: Postmus, I.

Publikováno v: None

Aim of this thesis was to investigate pharmacogenetic effects on response to statin treatment and the genetics of lipid metabolism and cardiovascular disease. In chapter 4 the first results of the Genomic investigation of Statin Therapy (GIST) consor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::af9f7cbadb79b79d6e8427d895205be3
https://hdl.handle.net/1887/31617

Heavier smoking may lead to a relative increase in waist circumference: Evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium

Autor: Morris, R.W., Taylor, A.E., Fluharty, M.E., Bjorngaard, J.H., Asvold, B.O., Elvestad Gabrielsen, M., Campbell, A., Marioni, R., Kumari, M., Korhonen, T., Männistö, S., Marques-Vidal, P., Kaakinen, M., Cavadino, A., Postmus, I., Husemoen, L.L.N., Skaaby, T., Ahluwalia, T.S., Treur, J.L., Willemsen, G., Dale, C., Wannamethee, S.G., Lahti, J., Palotie, A., Räikkönen, K., McConnachie, A., Padmanabhan, S., Wong, A., Dalgard, C., Paternoster, L., Ben-Shlomo, Y., Tyrrell, J., Horwood, J., Fergusson, D.M., Kennedy, M.A., Nohr, E.A., Christiansen, L., Kyvik, K.O., Kuh, D, Watt, G., Eriksson, J.G., Whincup, P.H., Vink, J.M., Boomsma, D.I., Davey Smith, G., Lawlor, D., Linneberg, A., Ford, I., Jukema, J.W., Power, C., Hyppönen, E., Jarvelin, M.R., Preisig, M., Borodulin, K., Kaprio, J., Kivimaki, M., Smith, B.H., Hayward, C., Romundstad, P.R., Sørensen, T.I.A., Munafò, M., Sattar, N.

Publikováno v: BMJ Open
Morris, R W, Taylor, A E, Fluharty, M E, Bjørngaard, J H, Åsvold, B O, Elvestad Gabrielsen, M, Campbell, A, Marioni, R, Kumari, M, Korhonen, T, Männistö, S, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Husemoen, L L N, Skaaby, T, Ahluwalia, T V S, Treur, J L, Willemsen, G, Dale, C, Wannamethee, S G, Lahti, J, Palotie, A, Räikkönen, K, McConnachie, A, Padmanabhan, S, Wong, A, Dalgård, C, Paternoster, L, Ben-Shlomo, Y, Tyrrell, J, Horwood, J, Fergusson, D M, Kennedy, M A, Nohr, E A, Christiansen, L, Kyvik, K O, Kuh, D, Watt, G, Eriksson, J G, Whincup, P H, Vink, J M, Boomsma, D I, Davey Smith, G, Lawlor, D, Linneberg, A, Ford, I, Jukema, J W, Power, C, Hyppönen, E, Jarvelin, M-R, Preisig, M, Borodulin, K, Kaprio, J, Kivimaki, M, Smith, B H, Hayward, C, Romundstad, P R, Sørensen, T I A, Munafò, M R & Sattar, N 2015, ' Heavier smoking may lead to a relative increase in waist circumference : evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium ', BMJ Open, vol. 5, no. 8, e008808 . https://doi.org/10.1136/bmjopen-2015-008808
BMJ Open, 5, 8
Bmj Open, vol. 5, no. 8, pp. e008808
Morris, R W, Taylor, A E, Fluharty, M E, Bjorngaard, J H, Asvold, B O, Elvestad Gabrielsen, M, Campbell, A, Marioni, R, Kumari, M, Korhonen, T, Männistö, S, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Husemoen, L L N, Skaaby, T, Ahluwalia, T S, Treur, J L, Willemsen, G, Dale, C, Wannamethee, S G, Lahti, J, Palotie, A, Räikkönen, K, McConnachie, A, Padmanabhan, S, Wong, A, Dalgard, C, Paternoster, L, Ben-Shlomo, Y, Tyrrell, J, Horwood, J, Fergusson, D M, Kennedy, M A, Nohr, E A, Christiansen, L, Kyvik, K O, Kuh, D, Watt, G, Eriksson, J G, Whincup, P H, Vink, J M, Boomsma, D I, Davey Smith, G, Lawlor, D, Linneberg, A, Ford, I, Jukema, J W, Power, C, Hyppönen, E, Jarvelin, M R, Preisig, M, Borodulin, K, Kaprio, J, Kivimaki, M, Smith, B H, Hayward, C, Romundstad, P R, Sørensen, T I A, Munafò, M & Sattar, N 2015, ' Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium ', BMJ Open, vol. 5, no. 8, pp. e008808 . https://doi.org/10.1136/bmjopen-2015-008808
BMJ Open, 5
Morris, R W, Taylor, A E, Fluharty, M E, Bjørngaard, J H, Åsvold, B O, Elvestad Gabrielsen, M, Campbell, A, Marioni, R, Kumari, M, Korhonen, T, Männistö, S, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Husemoen, L L N, Skaaby, T, Ahluwalia, T V S, Treur, J L, Willemsen, G, Dale, C, Wannamethee, S G, Lahti, J, Palotie, A, Räikkönen, K, McConnachie, A, Padmanabhan, S, Wong, A, Dalgård, C, Paternoster, L, Ben-Shlomo, Y, Tyrrell, J, Horwood, J, Fergusson, D M, Kennedy, M A, Nohr, E A, Christiansen, L, Kyvik, K O, Kuh, D, Watt, G, Eriksson, J G, Whincup, P H, Vink, J M, Boomsma, D I, Davey Smith, G, Lawlor, D, Linneberg, A, Ford, I, Jukema, J W, Power, C, Hyppönen, E, Jarvelin, M-R, Preisig, M, Borodulin, K, Kaprio, J, Kivimaki, M, Smith, B H, Hayward, C, Romundstad, P R, Sørensen, T I A, Munafò, M R & Sattar, N 2015, ' Heavier smoking may lead to a relative increase in waist circumference : evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium ', BMJ Open, vol. 5, no. 8, pp. e008808 . https://doi.org/10.1136/bmjopen-2015-008808
Morris, R W, Taylor, A E, Fluharty, M E, Bjørngaard, J H, Åsvold, B O, Elvestad Gabrielsen, M, Campbell, A, Marioni, R, Kumari, M, Korhonen, T, Männistö, S, Marques-Vidal, P, Kaakinen, M, Cavadino, A, Postmus, I, Husemoen, L L N, Skaaby, T, Ahluwalia, T V S, Treur, J L, Willemsen, G, Dale, C, Wannamethee, S G, Lahti, J, Palotie, A, Räikkönen, K, McConnachie, A, Padmanabhan, S, Wong, A, Dalgård, C, Paternoster, L, Ben-Shlomo, Y, Tyrrell, J, Horwood, J, Fergusson, D M, Kennedy, M A, Nohr, E A, Christiansen, L, Kyvik, K O, Kuh, D, Watt, G, Eriksson, J G, Whincup, P H, Vink, J M, Boomsma, D I, Davey Smith, G, Lawlor, D, Linneberg, A, Ford, I, Jukema, J W, Power, C, Hyppönen, E, Jarvelin, M-R, Preisig, M, Borodulin, K, Kaprio, J, Kivimaki, M, Smith, B H, Hayward, C, Romundstad, P R, Sorensen, T, Munafò, M R & Sattar, N 2015, ' Heavier smoking may lead to a relative increase in waist circumference : evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium ', BMJ Open, vol. 5, no. 8, e008808 . https://doi.org/10.1136/bmjopen-2015-008808
BMJ Open, 5(8). BMJ Publishing Group

OBJECTIVES: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity.DESIGN: Mendelian randomisation meta-analyse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8d82b2e7f2e64e9d8e320d6ee526e72f
https://hdl.handle.net/11250/2365370