Zobrazeno 1 - 10
of 1 658
pro vyhledávání: '"Postma Dirkje S"'
Autor:
Dijkstra Akkelies E, Postma Dirkje S, ten Hacken Nick, Vonk Judith M, Oudkerk Matthijs, van Ooijen Peter MA, Zanen Pieter, Mohamed Hoesein Firdaus A, van Ginneken Bram, Schmidt Michael, Groen Harry JM
Publikováno v:
Respiratory Research, Vol 14, Iss 1, p 11 (2013)
Abstract Background Increased airway wall thickness (AWT) and parenchymal lung destruction both contribute to airflow limitation. Advances in computed tomography (CT) post-processing imaging allow to quantify these features. The aim of this Dutch pop
Externí odkaz:
https://doaj.org/article/edd22c5a71b24ad2b858639db12e3319
Autor:
van den Berge Maarten, Hop Wim CJ, van der Molen Thys, van Noord Jan A, Creemers Jacques PHM, Schreurs Ad JM, Wouters Emiel FM, Postma Dirkje S
Publikováno v:
Respiratory Research, Vol 13, Iss 1, p 44 (2012)
Abstract Background Frequent exacerbations induce a high burden to Chronic Obstructive Pulmonary Disease (COPD). We investigated the course of exacerbations in the published COSMIC study that investigated the effects of 1-year withdrawal of fluticaso
Externí odkaz:
https://doaj.org/article/43f442043eee43cb84e53fc1d89a0706
Autor:
Postma Dirkje S, Slebos Dirk-Jan, Noordhoek Jacobien A, Brandenburg Simone M, Heijink Irene H, van Oosterhout Antoon J
Publikováno v:
Respiratory Research, Vol 12, Iss 1, p 110 (2011)
Abstract Background Cigarette smoke, the major risk factor for COPD, is known to activate matrix metalloproteinases in airway epithelium. We investigated whether metalloproteinases, particularly A Disintegrin and Metalloproteinase (ADAM)17, contribut
Externí odkaz:
https://doaj.org/article/0fb411236409478597433ec335c10484
Autor:
Rabe Klaus F, Schrumpf Jasmijn A, van Wijngaarden Simone, Timens Wim, Budulac Simona E, Snoeck-Stroband Jiska B, Lapperre Thérèse S, Kunz Lisette IZ, Postma Dirkje S, Sterk Peter J, Hiemstra Pieter S
Publikováno v:
Respiratory Research, Vol 12, Iss 1, p 34 (2011)
Abstract Background Macrophages have been implicated in the pathogenesis of COPD. M1 and M2 macrophages constitute subpopulations displaying pro- and anti-inflammatory properties. We hypothesized that smoking cessation affects macrophage heterogeneit
Externí odkaz:
https://doaj.org/article/81e8dd710c7548e1b167242db51ac19f
Autor:
Hylkema Machteld N, Postma Dirkje S, Jekel Henrike, Geerlings Marie, Timens Wim, Brandsma Corry-Anke, Kerstjens Huib AM
Publikováno v:
BMC Pulmonary Medicine, Vol 10, Iss 1, p 64 (2010)
Abstract Background Smoking is the major etiologic factor in COPD, yet the exact underlying pathogenetic mechanisms have not been elucidated. Since a few years, there is mounting evidence that a specific immune response, partly present as an autoimmu
Externí odkaz:
https://doaj.org/article/e3a222b616c24d0890d7e1ad9e9e2d8f
Autor:
Hylkema Machteld N, Dijkstra Antoon, Lodewijk Monique E, ten Hacken Nick HT, Volbeda Franke, Broekema M, Timens Wim, Postma Dirkje S
Publikováno v:
Respiratory Research, Vol 11, Iss 1, p 106 (2010)
Abstract Background The definition of "clinical asthma remission" is based on absence of symptoms and use of medication. However, in the majority of these subjects airway inflammation is still present when measured. In the present study we investigat
Externí odkaz:
https://doaj.org/article/a9890b6620544b13b8234be128bdb705
Autor:
Rutgers Bea, Vonk Judith M, Smit Henriette A, Siedlinski Mateusz, Kunz Lisette IZ, Hiemstra Pieter S, Postma Dirkje S, Budulac Simona E, Timens Wim, Boezen H Marike
Publikováno v:
Respiratory Research, Vol 11, Iss 1, p 60 (2010)
Abstract Background Multidrug resistance-associated protein-1 (MRP1) protects against oxidative stress and toxic compounds generated by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease (COPD). We have previou
Externí odkaz:
https://doaj.org/article/7250196176af42bab266d6e6b2d1b02d
Autor:
van Geffen Wouter H, Geerlings Marie, Hylkema Machteld N, Brandsma Corry-Anke, Postma Dirkje S, Timens Wim, Kerstjens Huib AM
Publikováno v:
Respiratory Research, Vol 10, Iss 1, p 108 (2009)
Abstract There is increasing evidence that a specific immune response contributes to the pathogenesis of COPD. B-cell follicles are present in lung tissue and increased anti-elastin titers have been found in plasma of COPD patients. Additionally, reg
Externí odkaz:
https://doaj.org/article/e694b9a46d5a4a74b865071b2bbc7566
Autor:
Siedlinski Mateusz, Postma Dirkje S, Boer Jolanda MA, van der Steege Gerrit, Schouten Jan P, Smit Henriette A, Boezen H Marike
Publikováno v:
Respiratory Research, Vol 10, Iss 1, p 73 (2009)
Abstract Background The metabolism of xenobiotics plays an essential role in smoking related lung function loss and development of Chronic Obstructive Pulmonary Disease. Nuclear Factor Erythroid 2-Like 2 (NFE2L2 or NRF2) and its cytosolic repressor K
Externí odkaz:
https://doaj.org/article/f90ddfa9477346259e460e597db29752
Autor:
Noordhoek Jacobien A, Jonker Marnix R, Postma Dirkje S, Zandvoort Andre, Vos Johannes TWM, Timens Wim
Publikováno v:
Respiratory Research, Vol 9, Iss 1, p 83 (2008)
Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is characterized by defective extracellular matrix (ECM) turnover as a result of prolonged cigarette smoking. Fibroblasts have a central role in ECM turnover. The TGFβ induced Smad pat
Externí odkaz:
https://doaj.org/article/cec7cb9a147f4b2f966f31114687ca77