Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Postis, VLG"'
Autor:
Vasilca, V, Sadeghpour, A, Rawson, S, Hawke, LE, Baldwin, SA, Wilkinson, T, Bannister, D, Postis, VLG, Rappolt, M, Muench, SP, Jeuken, LJC
Publikováno v:
Analytical Biochemistry
Screening assays performed against membrane protein targets (e.g. phage display) are hampered by issues arising from protein expression and purification, protein stability in detergent solutions and epitope concealment by detergent micelles. Here, we
Publikováno v:
Biochimica et Biophysica Acta
The field of membrane protein structural biology has been revolutionized over the last few years with a number of high profile structures being solved using cryo-EM including Piezo, Ryanodine receptor, TRPV1 and the Glutamate receptor. Further develo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0188127 (2017)
PLoS ONE, Vol 12, Iss 11, p e0188127 (2017)
Complement is an important part of innate immunity. The alternative pathway of complement is activated when the main opsonin, C3b coats non-protected surfaces leading to opsonisation, phagocytosis and cell lysis. The alternative pathway is tightly co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::878a351e90488b0b0e5ed672361ad90d
https://eprints.leedsbeckett.ac.uk/id/eprint/4596/1/CrystalStructurePV_POSTIS.pdf
https://eprints.leedsbeckett.ac.uk/id/eprint/4596/1/CrystalStructurePV_POSTIS.pdf
Autor:
Lee, SC, Knowles, TJ, Postis, VLG, Jamshad, M, Parslow, RA, Lin, YP, Goldman, A, Sridhar, P, Overduin, M, Muench, SP, Dafforn, TR
Despite the great importance of membrane proteins, structural and functional studies of these proteins present major challenges. A significant hurdle is the extraction of the functional protein from its natural lipid membrane. Traditionally achieved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6a6e818f281282fdc0efee742aac1032
Membrane proteins represent one of the most important targets for pharmaceutical companies. Unfortunately, technical limitations have long been a major hindrance in our understanding of the function and structure of such proteins. Recent years have s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::05bd4665aebc4227d7e0c321fe7f6797
Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue GltPh, an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::57ac2b96a13ec02f32417dac8324a239
Autor:
Fessl, T, Crossley, JA, Watkins, D, Scholz, M, Watson, MA, Sabir, T, Radford, SE, Collinson, I, Tuma, R
Single-molecule techniques provide insights into the heterogeneity and dynamics of ensembles and enable the extraction of mechanistic information that is complementary to high-resolution structural techniques. Here, we describe the application of sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c51ec0fd1bbe47e47dca220d0d4468ac
Native mass spectrometry and native ion mobility mass spectrometry are now established techniques in structural biology, with recent work developing these methods for the study of integral membrane proteins reconstituted in both lipid bilayer and det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::18969307993c84fdd38669e6caeaeef1
Autor:
Higgins AJ; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK., Flynn AJ; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK., Marconnet A; Université de Paris, Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, CNRS, UMR 7099, F-75005, Paris, France.; Institut de Biologie Physico-Chimique, Fondation Edmond de Rothschild pour le dévelopement de la recherche scientifique, F-75005, Paris, France., Musgrove LJ; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK., Postis VLG; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, DD1 5EH, UK., Lippiat JD; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK., Chung CW; GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Ceska T; UCB Pharma, Slough, SL1 3WE, UK., Zoonens M; Université de Paris, Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, CNRS, UMR 7099, F-75005, Paris, France. zoonens@ibpc.fr.; Institut de Biologie Physico-Chimique, Fondation Edmond de Rothschild pour le dévelopement de la recherche scientifique, F-75005, Paris, France. zoonens@ibpc.fr., Sobott F; School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK. f.sobott@leeds.ac.uk., Muench SP; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK. s.p.muench@leeds.ac.uk.
Publikováno v:
Communications biology [Commun Biol] 2022 Jan 05; Vol. 5 (1), pp. 1. Date of Electronic Publication: 2022 Jan 05.
Autor:
Higgins AJ; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK., Flynn AJ; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK., Marconnet A; Université de Paris, Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, CNRS, UMR 7099, F-75005, Paris, France.; Institut de Biologie Physico-Chimique, Fondation Edmond de Rothschild pour le dévelopement de la recherche scientifique, F-75005, Paris, France., Musgrove LJ; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK., Postis VLG; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK.; Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, DD1 5EH, UK., Lippiat JD; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK., Chung CW; GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Ceska T; UCB Pharma, Slough, SL1 3WE, UK., Zoonens M; Université de Paris, Laboratoire de Biologie Physico-Chimique des Protéines Membranaires, CNRS, UMR 7099, F-75005, Paris, France. zoonens@ibpc.fr.; Institut de Biologie Physico-Chimique, Fondation Edmond de Rothschild pour le dévelopement de la recherche scientifique, F-75005, Paris, France. zoonens@ibpc.fr., Sobott F; School of Molecular and Cellular Biology, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK. f.sobott@leeds.ac.uk., Muench SP; School of Biomedical Sciences, Faculty of Biological Sciences & Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK. s.p.muench@leeds.ac.uk.
Publikováno v:
Communications biology [Commun Biol] 2021 Nov 25; Vol. 4 (1), pp. 1337. Date of Electronic Publication: 2021 Nov 25.