Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication.

Autor: Ogando NS; Department of Medical Microbiology, Leiden University Medical Center 2333 ZA Leiden, The Netherlands., El Kazzi P; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique, Aix-Marseille Université 13288 Marseille, France., Zevenhoven-Dobbe JC; Department of Medical Microbiology, Leiden University Medical Center 2333 ZA Leiden, The Netherlands., Bontes BW; Department of Medical Microbiology, Leiden University Medical Center 2333 ZA Leiden, The Netherlands., Decombe A; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique, Aix-Marseille Université 13288 Marseille, France., Posthuma CC; Department of Medical Microbiology, Leiden University Medical Center 2333 ZA Leiden, The Netherlands., Thiel V; Institute of Virology and Immunology (IVI) 3350 Bern, Switzerland.; De partment of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern 3012 Bern, Switzerland., Canard B; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique, Aix-Marseille Université 13288 Marseille, France.; European Virus Bioinformatics Center (EVBC), Jena 07743, Germany., Ferron F; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique, Aix-Marseille Université 13288 Marseille, France.; European Virus Bioinformatics Center (EVBC), Jena 07743, Germany., Decroly E; Architecture et Fonction des Macromolécules Biologiques, Centre National de la Recherche Scientifique, Aix-Marseille Université 13288 Marseille, France; E.J.Snijder@lumc.nl Etienne.decroly@univ-amu.fr., Snijder EJ; Department of Medical Microbiology, Leiden University Medical Center 2333 ZA Leiden, The Netherlands; E.J.Snijder@lumc.nl Etienne.decroly@univ-amu.fr.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Dec 07; Vol. 118 (49).

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2.

Autor: Ogando NS; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Zevenhoven-Dobbe JC; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., van der Meer Y; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Bredenbeek PJ; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Posthuma CC; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Snijder EJ; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands E.J.Snijder@lumc.nl.

Publikováno v: Journal of virology [J Virol] 2020 Nov 09; Vol. 94 (23). Date of Electronic Publication: 2020 Nov 09 (Print Publication: 2020).

Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors.

Autor: de Wilde AH; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Boomaars-van der Zanden AL; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., de Jong AWM; Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Bárcena M; Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Snijder EJ; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands e.j.snijder@lumc.nl., Posthuma CC; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Journal of virology [J Virol] 2019 Aug 28; Vol. 93 (18). Date of Electronic Publication: 2019 Aug 28 (Print Publication: 2019).

Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues.

Autor: Yoon JS; Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 151-742 , Korea., Kim G; Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 151-742 , Korea.; College of Pharmacy and Research Institute of Drug Development , Chonnam National University , Gwangju 500-757 , Korea., Jarhad DB; Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 151-742 , Korea., Kim HR; Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 151-742 , Korea., Shin YS; Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 151-742 , Korea., Qu S; Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 151-742 , Korea.; College of Pharmaceutical Engineering , Henan University of Animal Husbandry and Economy , Zhengzhou , 450046 , China., Sahu PK; Future Medicine Co., Ltd. , Seoul 06665 , Korea., Kim HO; Future Medicine Co., Ltd. , Seoul 06665 , Korea., Lee HW; Future Medicine Co., Ltd. , Seoul 06665 , Korea., Wang SB; College of Pharmacy , Ewha Womans University , Seoul 120-750 , Korea., Kong YJ; College of Pharmacy , Ewha Womans University , Seoul 120-750 , Korea., Chang TS; Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 151-742 , Korea.; College of Pharmacy , Ewha Womans University , Seoul 120-750 , Korea., Ogando NS; Department of Medical Microbiology , Leiden University Medical Center , Albinusdreef 2 , 2333ZA Leiden , The Netherlands., Kovacikova K; Department of Medical Microbiology , Leiden University Medical Center , Albinusdreef 2 , 2333ZA Leiden , The Netherlands., Snijder EJ; Department of Medical Microbiology , Leiden University Medical Center , Albinusdreef 2 , 2333ZA Leiden , The Netherlands., Posthuma CC; Department of Medical Microbiology , Leiden University Medical Center , Albinusdreef 2 , 2333ZA Leiden , The Netherlands., van Hemert MJ; Department of Medical Microbiology , Leiden University Medical Center , Albinusdreef 2 , 2333ZA Leiden , The Netherlands., Jeong LS; Research Institute of Pharmaceutical Sciences, College of Pharmacy , Seoul National University , Seoul 151-742 , Korea.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Jul 11; Vol. 62 (13), pp. 6346-6362. Date of Electronic Publication: 2019 Jun 20.

Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture.

Autor: de Wilde AH; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: A.H.de_Wilde@lumc.nl., Zevenhoven-Dobbe JC; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Beugeling C; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Chatterji U; Department of Immunology & Microbiology, The Scripps Research Institute, La Jolla, CA 92037, United States., de Jong D; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands., Gallay P; Department of Immunology & Microbiology, The Scripps Research Institute, La Jolla, CA 92037, United States., Szuhai K; Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands., Posthuma CC; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Snijder EJ; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: E.J.Snijder@lumc.nl.

Publikováno v: Virology [Virology] 2018 Apr; Vol. 517, pp. 148-156. Date of Electronic Publication: 2017 Dec 15.